Acid-Base Behaviour of Amino Acids: Substituted Ammonium Ion and Iso-electric Point
Amino acids exhibit either weak acid or weak base behavior based on their ka and kb values. The iso-electric point, where an amino acid doesn't migrate towards any electrode, is crucial. Learn about the cationic and anionic forms in equilibrium and the concept of pI. Glycine's pI lies at pH 6.1. Discover more about the fascinating acid-base properties of amino acids in this informative content.
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Presentation Transcript
Dr. Ravish Chauhan Associate Professor IGN College, Ladwa
Acid-Base behaviour of Amino acids Act as weak acids (low ka) or weak bases (low kb): Substituted ammonium ion (+NH3) act as proton donor, acid and carboxylate ion (COO-) act as proton acceptor, base. Iso-electric Point of Amino acids The dipolar amino acid exist in equilibrium with anionic and cationic form. H3O+ R CH---COO- H3O+ R CH---COO- R CH---COOH | ==== | ====== | + NH3 OH-+ NH3 OH- Cationic form Dipolar ion Anionic form The pH at which the amino acid does not migrate towards any electrode is known as iso-electric point (pI) of amino acid. For glycine, isoelectric point is at p 6.1. At isoelectric point the solubility of amino acid is minimum. NH2
