Advanced Biomedical Informatics Research Projects
Explore cutting-edge projects in translational informatics applied to drug safety, natural product-drug interactions, utilizing knowledge graphs, interventions for improving drug safety, and creating pathways for Deaf scientists in STEM fields. Join the innovative research endeavors led by Dr. Richard D. Boyce and his team at the University of Pittsburgh.
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Presentation Transcript
Translational Informatics Applied to Drug Safety (TrIADS) Richard D. Boyce, PhD Associate Professor of Biomedical Informatics and Clinical and Translational Science in the Clinical and Translational Science Institute Associate Director of the University of Pittsburgh NLM Biomedical Informatics Training Program Secondary appointments to the School of Pharmacy and the School of Computing and Information Site PI - Informatics Core for the Center of Excellence for Natural Product- Drug Interaction Research (NaPDI) Faculty, Center for Pharmaceutical Policy and Prescribing rdb20@pitt.edu / 206-371-6186
Natural Product-Drug Interaction (NPDI) research NCCIH Grant# U54 AT008909 Analytical core Pharmacology core R21 Grantees Informatics core In vitro Enzyme and Transporter studies Pharmacovigilance NPDI signal detection Metabolomics Data Repository Chemical Dissemination via Public Portal Pilot clinical decision support artifacts Characterization of Material In vivo NPDI studies Natural Product Selection Microbiome studies Goal: Translate work on this project to a start up and pursue STTR and investment funding
Synergizing Parameterized Knowledge in LLMs with biomedical knowledge graphs Planned NIGMS or NLM R01 submission Evaluation of different approaches to retrieval augmented generation to answer clinician questions about rare diseases Utilization of LLM context window vs full retrieval/generation system training Metadata generation vs structured tagging
Interventions that improve drug safety Planned AHRQ Grant R01 A learning lab approach to addressing failure mode analysis of care transitions involving older adults focused on medication safety Identification of failure modes that can be monitored/intervened upon using rules/ML over EHR data and other data sources. Intervention design and evaluation
Creating a training pathway for future Deaf scientists Pitt Momentum 2021 and NLM R25 (R25LM014208) STEM faculty have little or no experience mentoring Deaf students Build a learning system involving Pitt, Gallaudet, and the UPMC Hillman Cancer Center Academy that will measurably improve STEM education for Deaf/HoH
Mentoring Sanya Taneja, MS (NCCIH U54 RA and PhD student) Israel Dilan-Pantojas (NLM T15 PhD student)
