Affine Gap Alignment and Realism Control for String Transformation

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Explore the concepts of affine gap alignment and realism control in transforming strings, considering different scenarios and approaches such as inserting Ts, deleting Cs, and transforming Cs to Ts. Understand the significance of gaps in achieving alignment accuracy.

  • Affine Gap Alignment
  • Realism Control
  • String Transformation
  • Alignment Accuracy

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Presentation Transcript


  1. Affine Gap Alignment (y know, the one with and )

  2. Realism Control Readability Why? Consider: String 1: ACCCCCCCCCA String 2: ATCCTA

  3. What changes could transform string 1 into string 2? Scenario 1: Insert Ts Delete Cs String 1: ACCCCCCCCCA String 2: ATCCTA

  4. What changes could transform string 1 into string 2? Scenario 2: Transform Cs to Ts Delete Cs String 1: ACCCCCCCCCA String 2: ATCCTA

  5. What changes could transform string 1 into string 2? String 1: ACCCCCCCCCA String 2: ATCCTA Scenario 3: All Cs are deleted TCCT is inserted

  6. All gaps created equal <

  7. - = -1 - = -1 Which scenario does this reflect?

  8. Some gaps more equal than others <

  9. - = -2 - = -1 Which Scenario does this reflect?

  10. Six tables Initial middle How though? Triple loop Backtrack as [source table, direction]

  11. HAGS

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