Alkaloids: Types, Biosynthesis, and Medicinal Importance
Explore the world of alkaloids, with a focus on indole alkaloids, ergot alkaloids, and their derivatives such as ergotamine and psilocybin. Learn about their biosynthesis, medicinal uses, and potential side effects. Discover the role of alkaloids in pharmacognosy and their impact on neurological disorders like Parkinson's disease.
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Presentation Transcript
Pharmacognosy Pharmacognosy alkaloids alkaloids LEC4
INDOLE ALKALODS a class of alkaloid containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine.
ERGOTAMINE Is used to relief migraine and is still used today It reduces vasodilatation , side effects include gangrene
The ergot alkaloid were used as a template for the semi-synthetic of bromocriptine, pergolide and cabergolide, which have use in neurological disorder such as Parkinson s disease. Ergot can cause hallucination and the hallucinogenic drug of abuse LSD(lysergic acid diethylamide) is structurally relatted to them. LSD
PSILOCYBIN Mushrooms of the genera Psilocybe, Panaeolus, Conocybe and Stropharia are known to produce psychoactive substance such as psilocybin, which is salt in the fungi and is converted into psilocin in vivo.
