Analysis of Alkanes and Cycloalkanes Peaks in Pharmaceutical Applications
In this advanced pharmaceutical analysis lecture, the presentation covers the interpretation of peaks for alkanes and cycloalkanes. Straight-chain alkanes exhibit weak preference for small R groups, while branched alkanes show more fragmentation at highly branched positions. Cycloalkanes have a relatively large M peak with significant peaks at M-28 due to loss of ethylene. Understanding these peak patterns is crucial for identifying and analyzing compounds in pharmaceutical research and development.
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Presentation Transcript
Advanced pharmaceutical analysis Lect. 2
Alkanes Straight Chain Alkanes [R-R ] R + R [M ]= weak * preference small R C3H7 , C4H8 ,C5H11 A peak for M-CH3 is often weak or absent
Branched Alkanes Smaller M peak; may be absent More fragmentation at highly branched positions * preference for 2 , 3 carbocation
Cycloalkanes Relatively large M peak Significant peak at M-28 (often the base peak) due to loss of ethylene M-15: from rearrangement
