ANTI FUNGAL DRUGS
Anti-fungal drugs play a crucial role in treating fungal infections. They can originate from natural sources or be synthetic agents. Polyene antibiotics such as Amphotericin B and Nystatin work by disrupting fungal cell membranes, while azoles and triazoles inhibit key enzymes in ergosterol biosynthesis. Understanding the mechanisms of action is essential for effective treatment.
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Presentation Transcript
ANTI FUNGAL DRUGS (Drugs used in the treatment of fungal infections) Natural origin: Amphotericin B, Nystatin, Griseofulvin, Natamycin (Pimaricin), Echinocandins Synthetic agents: Antimetabolites-Flu cytosine, Allylamines- Tolnaftate Azoles- Imidazole: Butaconazole, Clotrimazole Econazole, ketoconazole, Micozazole, Triazole: Intraconazole, fluconazole
POLYENE-ANTIBIOTICS Polyenes work by inserting themselves into cell membranes. This results in a rise in membrane permeability and loss of cytoplasmic constituents which is detrimental to fungal cell viability.
Azoles synthetic anti- fungal agents Azole antifungals are noncompetitive inhibitors that exert their antifungal effects by binding to lanosterol 14 -demethylase, a key enzyme in the biosynthesis of ergosterol
