Antipsychotic Drugs and Managing Schizophrenia

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Explore the dopamine hypothesis of schizophrenia, receptor blocking actions of antipsychotic drugs, established toxicities of specific medications, and unique pharmacokinetic features of lithium in bipolar disorder treatment. Gain insights into managing schizoid affective disorder through medication selection.

  • Antipsychotic drugs
  • Schizophrenia treatment
  • Pharmacodynamics
  • Lithium therapy
  • Bipolar disorder

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Presentation Transcript


  1. Checklist When you complete this chapter, you should be able to: Describe the "dopamine hypothesis" of schizophrenia. Identify 4 receptors blocked by antipsychotic drugs. Describe the relationship of receptor-blocking actions to the pharmacodynamics of both the older and the newer (atypical) antipsychotics. Identify the established toxicities of each of the following drugs: chlorpromazine, clozapine, haloperidol, thioridazine, ziprasidone. Describe tardive dyskinesia and the neuroleptic malignant syndrome. Identify the distinctive pharmacokinetic features of lithium, and list its adverse effects and toxicities. List the "alternative" drugs used in bipolar disorder.

  2. A 28-year-old woman with schizoid affective disorder and difficulty sleeping would be most benefited by which of the following drugs? A. Aripiprazole. B. Chlorpromazine. C. Haloperidol. D. Risperidone. E. Ziprasidone.

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