Aromatic Electrophilic Substitution Mechanism Explained
Aromatic electrophilic substitution involves the formation of arenium ion intermediates, leading to halogenation in the presence of Lewis acids. This method, restricted to chlorination or bromination, follows a bimolecular mechanism with deprotonation as a key step. Learn more about this mechanism and the introduction of halogens into aromatic rings.
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Aromatic-aliphatic and synthesis drill and practice Where is my most sensitive-to-reaction site ? (the chemical G spot) COOH KMnO4 or K2Cr2O7 or HNO3 or HCrO4 Cuts chain to stub => vasectomy What are the Birch reduction reactants and product below? Na/NH3 in CH3OH Destroys aromaticity =>lobotomy
Aromatic-aliphatic and synthesis drill and practice (cont.) DOING THINGS RETRO Mg/ dry ether Fe or FeBr3 /Br2 Br Mg O H+/H2O OH Mg Br dry ether Br 80% H2SO4 reflux H O NBS/light CH2N2/Cu light 80% H2SO4 reflux OH Deerene?
Aromatic-aliphatic and synthesis drill and practice DOING THINGS RETRO (cont.) O Mg/ dry ether Br H+/H2O OH H Dry ether AlCl3 neat O O N2H4/OH- Cl Reaction name ? or Zn-Hg/HCl heat Reaction name ? Wolff-Kishner reduction Clemmensen reduction KOH In ethanol What s my name? NBS/light styrene
Aromatic-aliphatic and synthesis drill and practice (cont.) Industrial route to styrene ??? ZnO/60 oC Order the reactivity of Br below from highest to lowest reactivity Br A B Br C Br A > C >B Cl AlCl3 H + C 3 Cl Cl neat H
http://introvertspring.com/wp-content/uploads/2014/08/Cat-Hiding-Under-Blanket.jpghttp://introvertspring.com/wp-content/uploads/2014/08/Cat-Hiding-Under-Blanket.jpg Organic Chemistry makes me want to hide all day under a blanket .
