Bio-Orthogonal Catalysis for Cancer Therapy Research Projects
Explore the innovative research projects focusing on bio-orthogonal catalysis for cancer therapy at the University of Edinburgh. Follow ESR5 Fellow Stephen Croke's trajectory in developing bioorthogonal approaches for targeted protein degradation and PROTAC assembly. Gain insights into objectives, skills, and secondments related to this cutting-edge field.
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Presentation Transcript
Bio-ortogonal catalysis for cancer therapy Institution Logo Stephen Croke ESR5 Fellow Institution: University of Edinburgh Group: BOOM Chemistry @BOOMchemistry Supervisor: Prof. Asier Unciti-Broceta E-mail: scroke@ed.ac.uk Mid-Term Check Meeting Edinburgh, 5th June 2019 Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Insttution Logo Personal trajectory Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Background and skills Organic Synthesis Fluorescent probes Oligonucleoside Peptide synthesis Biology Assay development Fluorescent Imaging SAR studies Drug design Prep-HPLC Analytical Chemistry Method development UPLC-MS NMR characterisation Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Research project Developing bioorthogonal approaches for PROtein TArgetting Chimera (PROTAC) Ligand for E3 ligase Warhead for target protein Linker Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Research project In vivo PROTAC assembly for targeted protein degradation Dasatinib Cereblon (E3 ligase ligand) (ligand of oncoproteins BCR-ABL and SRC) click assembled PROTAC Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Research project Objectives 1. Synthesis library of Cu assembled PROTACs 2. Investigate reaction kinetics of Cu-mediated PROTAC synthesis ranked 3. PROTAC assembly study in cell culture Foreseen research 1. Organic synthesis 2. Assay development 3. Proteomics 4. Kinetic studies Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Secondments Secondment 1 1. Institution and sector: Tagworks Pharmaceuticals, industrial 2. Duration: 4 months 3. Main research objectives: Imaging studies, protein functionalization and in vivo studies 4. New knowledge and competences expected to be acquired: Protein chemistry, animal models, in vivo imaging, industrial R&D experience Secondment 2 1. Institution and sector: Tel Aviv University, academic 2. Duration: 3 months 3. Main research objectives: Test micelles catalysts 4. New knowledge and competences expected to be acquired: Polymer chemistry, kinetic studies Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Scientific and Transversal Skills Training Local training B&B Symposium Cell-based assay training 3 minute thesis NP synthesis training Tissue culture training April May May June Nov 2019 2020 Chemical biology symposium Western blot training Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Institution Logo Scientific and Transversal Skills Training Network wide training TUE Basel UoE M24 IBEC M36 TAU 25-29th/05/19 23-27th/09/19 M30 Chemical synthesis & catalysis Going in vivo, chemistry and cancer biology Getting ready for next career step How to plan & start a PhD Drug delivery & microscopy PhD studies University: University of Edinburgh Title of PhD: PhD in Molecular Medicine Enrolment: 10/11/2018 Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
Bio-ortogonal catalysis for cancer therapy Institution Logo Thank you for listening Innovative Training Networks (ITN) Marie Sk odowska-Curie Actions H2020-MSCA-ITN-2017 (THERACAT-765497)
