Biochemistry of Blood: Course Outline, Assessment, and References
Dive into the biochemistry of blood with Nora Aljebrin through topics like blood composition, plasma proteins, blood coagulation, and erythropoiesis. Explore course assessment details and recommended references for an in-depth understanding of this vital area of study.
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BCH 471 Biochemistry of Blood Nora Aljebrin Email: naljebrin@ksu.edu.sa Website: www.fac.ksu.sa/naljebrin Office: Building 5 , 3rd floor, 304
Course Outline Lecture no. Topics Blood; Its function, physical properties and composition: blood cells, plasma, serum, anticoagulants, 1-2 blood parameters: CBC, red cell indices; hematocrite; erythrocyte sedimentation rate and its significance. Blood plasma; its normal composition and variation in disease states 3 Plasma proteins: types (albumin, 1, 2, 1, 2, -globulins and fibrinogen); functions, biosynthesis; 4-7 abnormalities, variation in different diseases; liver diseases, kidney diseases; multiple myeloma.
Course Outline Lecture no. Topics Platelets; Blood coagulation pathways and homeostasis; disorders of blood clotting. Vitamin K deficiency; hemophilia 8-10 White blood cells, types, and structure, function and abnormalities; leukemia and other neoplasia. 11 Erythrocytes: structure and composition; erythrocyte membrane and cytoskeleton; advantage and disadvantage of 12 anucleated cells Hemoglobin: structure and function allosteric protein. O2binding and effect of different factors on oxygen binding: 13-15 cooperative effect bohr's effect; biosynthesis of hemoglobin and its requirements; types of hemoglobin; variation in hemoglobin types during development (ontogeny) Red cell metabolism; glycolysis, pentose phosphate pathway; importance of glutathione; G6PDH deficiency and other 16-17 enzyme deficiency and other enzyme deficiencies affecting red cell metabolism
Course Outline Lecture no. Topics Erythrocyte hemolysis; heme degradation and bilirubin formation: conjugation and excretion of 18-20 bilirubin; Jaundice and its types Anaemias: definition and types. Acquired and genetic anaemias; iron deficiency anaemia; aplastic 21-22 anaemia; sickle cell anaemia; thalassaemias; G-6-PD deficiency; polycythaemia Blood formation: erythropoiesis; requirements; erythropoietin regulation; disorders of blood 23-24 formation Blood groups and blood transfusion; ABO, Rh, and duffy blood groups 25
Course Assessment Mid 1 14 marks 14 marks o o Mid 2 o Homework 2 marks o Lab 30 marks Total 60 marks Midterm Exam dates Mid 1: 9/2/1441 or 14/2/1441 https://encrypted-tbn3.gstatic.com/images?q=tbn:ANd9GcSN6VMlfTo-xaL5YIRg4JoWqKaiUDQB3utuX_tvgZTkp963ThmZUw Mid 2:8/3/1441 or 13/3/1441 o Final 40 marks
References Harpers illustrated biochemistry 25th edition. Robert K. Murray; Darly K. Granner; Victor W Rodwel Principles of Biochemistry: Mammalian Biochemistry 7th edition. Emil L. Smith, Robert L.HILL, I Robert Lehman, Robert J. Lefkowitz, Philip Handler, Abraham White. Basic Histology: Text and Atlas 11th edition. Luiz Carlos Juqueria, Jose Carneiro Tietz Fundamentals of Clinical Chemistry Carl A. Burti, Edward R. Ashwood, David E. Bruns
