Biomedical Systems Modeling and Pharmacokinetics Overview
Explore the world of biomedical systems modeling with a focus on pharmacokinetics, including mechanisms of drug absorption, distribution, metabolism, and excretion. Learn about one-compartment models, intravenous bolus injections, elimination kinetics, renal clearance, and more. Dive into the intricacies of one-compartment modeling in biomedical engineering at Kyung Hee University. Enhance your understanding of clearance rates, drug elimination, and the role of different organs in drug metabolism. Discover the complexities of drug administration and the dynamics of drug concentrations in the human body.
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Presentation Transcript
One Compartment Modeling Biomedical Systems and Simulations Dept. of Biomedical Engineering Kyung Hee University
Pharmacokinetics: Mechanisms Absorption Distribution Metabolism Excretion (main topic for project) Pharmacokinetics Online Content for Student https://sepia2.unil.ch/pharmacology/mechanisms/ Focus on clearance of drug https://sepia2.unil.ch/pharmacology/parameters/clearance/
Pharmacokinetics: Clearance Clearance Rate of drug elimination divided by plasma concentration, giving a volume of plasma from which drug is completely removed per unit of time https://sepia2.unil.ch/pharmacology/parameters/clearance/
Intravenous Bolus Injection Intravenous Bolus Injection Drug administration through the intravenous route over a negligible period of time https://sepia2.unil.ch/pharmacology/profiles/intravenous-bolus/
Elimination Kinetics Elimination Kinetics Zero-order elimination kinetics : Elimination of a constant quantity per time unit of the drug quantity present in the organism. First order elimination kinetics : Elimination of a constant fraction per time unit of the drug quantity present in the organism. The elimination is proportional to the drug concentration. https://sepia2.unil.ch/pharmacology/parameters/elimination-kinetics/
Renal Clearance Renal Clearance Part of the total clearance due to renal excretion https://sepia2.unil.ch/pharmacology/parameters/renalclearance/
Extra Info for Compartment Modeling Extra Materials for Compartment Modeling http://virtualrat.org/introduction-compartmental-modeling Example 1: same as our project 1, a single compartment model
Extra Info for Compartment Modeling Pharmacokinetic Modeling with Matlab Create Pharmacokinetic Models with Matlab https://kr.mathworks.com/help/simbio/ug/creating-pharmacokinetic-models.html One compartment model (example) https://kr.mathworks.com/help/simbio/gs/construct-a-simple-model.html
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