Biotin-dependent Carboxylase Activity and Enzyme Domains Analysis
Explore the functionality and alignment of PTHR18866 carboxylase enzyme, including reactions, domains, and alignment with related proteins. Learn about the propagation of biotin carboxylase activity and its implications. Discover insights into various carboxylase activities in different cellular processes.
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Presentation Transcript
PTHR18866 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE (biotin-dependent carboxylases)
PTHR18866 domains Only BC is aligned well in the family and some of the BCCP
PTHR18866 alignment & pruning PTN001051111(top node) - alignment not good + gene names PTN001821692(2nd node) - some BCCP, but aligned to the BC domain PTN001821812 - 2 proteins PTN001821906(last node) decarboxylases, BC doesn t align well PTN000429567 PTN000429781 single protein PTN001051113
PTHR18866 annotations After pruning, the alignment is good Biotin carboxylase activity can be propagated to all Could also propagate biotin binding and ATP binding
PTN000429799 - PCC activity PCC activity mitochondria amino acid and fatty acid catabolic processes (pmid:1000000221)
PTN000429426 - PYC Pyruvate-CoA carboxylase activity there is a difference in localization between fungi and animals: cytosolic vs mitochondrial BP: oxaloacetate metabolic process + gluconeogenesis
PTN001051134 - UCA Allophanate hydrolase activity plus urea carboxylase activity there is http localization to cytosol BP: allantoin and urea catabolic process
PTN000429606 - ACC Acetyl-CoA carboxylase activity all cytoplasmic, except yeast hfa1 and clade including ACC2 - these are mitochondrial propagated fatty acid biosynthetic process , acetyl-CoA metabolic process, malonyl-CoA biosynthetic process and lipid metabolic process
PTN000429500 - MCC methyl-crotonyl-CoA carboxylase mitochondrial localization leucine catabolic process
