Cannula Placements in Infralimbic Cortex: Photomicrograph Illustration
A photomicrograph displaying cannula placements in the infralimbic cortex for experiments. Further analyses and data visualization provided for varenicline impact on responses and performance in the 3-CSRTT paradigm.
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Presentation Transcript
Supplementary Figure S1. Cannula placements in the infralimbic cortex (Experiments 2). A representative photomicrograph shows the coronal section of a typical site of injection cannulae.
Increase rate of premature responses (%) r = - 0.21 by varenicline 0.075 mg/kg The number of premature responses at vehicle Supplementary Figure S2. Scatter plot of the number of premature responses at vehicle and the increase rate of premature responses by varenicline (0.075 mg/kg) administration (Experiments 1 and 2). Each increase rate was calculated by (premature responses at 0.075mg/kg of varenicline / premature responses at vehicle - 1) x 100.
Premature responses Varenicline (0.075 mg/kg, p.o.) Accuracy (%) Nicotine Pump Nicotine Pump 12 13 14 15 16 17 18 10 4 5 6 9 7 8 1 2 3 Day Omissions 12 13 14 15 16 17 18 10 4 5 6 9 7 8 1 2 3 Day Supplementary Figure S3. Time course of main parameters in the 3-CSRTT during Experiment 5.
Perseverative responses Correct response latency (s) Varenicline (0.075 mg/kg, p.o.) Nicotine Pump Nicotine Pump Responses during time-out Reward latency (s) 12 13 14 15 16 17 18 10 4 5 6 9 7 8 1 2 3 12 13 14 15 16 17 18 10 4 5 6 9 7 8 1 2 3 Day Day Supplementary Figure S4. Time course of other parameters in the 3-CSRTT during Experiment 5.
Varenicline (0.075 mg/kg, p.o.) pump out pump in Water (3 ml/kg, p.o.) 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 day 2 1 Nicotine infusion withdrawal Correct response latency (s) Perseverative responses * Accuracy (%) Premature responses * Responses during time-out * Reward latency (s) Omissions Water Varenicline Water Varenicline Water Varenicline Water Varenicline Supplementary Figure S5. the effects of varenicline on performance in the 3-CSRTT after discontinuing nicotine infusion (n=5). The average performances during the period surrounded by dotted lines were used for the comparison. * p < 0.05.
