Cognitive Function and Arterial Alterations in Hypertension Study
Explore the correlation between cognitive function and arterial properties in individuals with hypertension. Findings suggest that arterial alterations contribute to reduced cognitive function in adults with hypertension compared to normotensive counterparts. This observational study presented at the 26th European Meeting on Hypertension in Paris highlights the impact of hypertension on cognitive performance.
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26thEuropean Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Arterial Alterations Contributed to Reduced Cognitive Function in Hypertension From ESH 2016 | POS 3C: Luiz Aparecido Bortolotto, MD, PhD Heart Institute, University of S o Paulo, Brazil Infomedica Conference Coverage* of 26thEuropean Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 * Infomedica is an independent medical education provider that produces medical information to healthcare professionals through conference coverage and online educational programs and activities. Powered by Infomedica
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Overview Observational study of global and domain-specific cognitive function and the correlation between cognitive performance and arterial properties in Stage 1 to 3 hypertension vs normotension Cognitive impairment was more frequent in adults with than without arterial hypertension Arterial alterations contributed to reduced domain- specific cognitive function Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Study Population 162 adults; of 120 adults with hypertension, 40% had Stage 2, 30% Stage 1, 30% Stage 3 Exclusion criteria were current smoking, diabetes, arrhythmia, ventricular dysfunction, and neurodegenerative disease Hypertension group significantly older, fewer were white, shorter duration of education, higher levels of systolic and diastolic blood pressure Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Baseline Characteristics in Study Patients Study groups Variable p value Control (42) HTN (120) Age, mean (SD) 44.74(11.42) 51.07(11.05) 0.003 Sex, Male No (%) 29 (69) 55 (45.8) 0.636 Race, white, No (%) 37(88.1) 83 (69.2) <0.001 BMI (kg/m2) 26.98(3.96) 29.74(4.63) 0.238 Education, mean (SD) y 14.88(4.06) 9.99(4.43) <0.001 SBP, mean (SD) mmHg 121.90(7.15) 141,45(23,48) <0.001 DBP, mean (SD) mmHg 76.12(6.95) 87,28(13,42) 0.003 BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure. Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Results Some arterial parameters significantly higher in hypertension vs control, adjusted for age and difference in blood pressure Carotid artery diameter, mean pulse wave velocity, mean augmentation index, mean central SBP, mean central DBP Scores for global cognitive status significantly lower in hypertension vs control, adjusted for age and duration of education Mini Mental Status Examination 26.97 vs 28.6 and Montreal Cognitive Assessment 23.86 vs 26.7 (p<0.01 for both) Each of 5 cognitive function domains significantly lower in hypertension vs control, adjusted for age and duration of education Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Cognitive Function in Five Domains by Study Group Study groups Variable p value Control (42) HTN (125) Language 86,18 6 68,03 5 <0.01 Memory 62.91 4 56.21 4 <0.01 Executive Functions (time, s) 192 26 332 54 <0.05 Spatial and visual perception 38.58 3 34.83 4 <0.05 Concentration 78.05 7 56.23 7 <0.01 HTN, hypertension. Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Correlation of Arterial Properties and Cognitive Outcomes Significant inverse relation found between augmentation index and global cognitive tests, adjusted for age and duration of education Augmentation index correlated with executive function, language, visual spatial perception, concentration Pulse wave velocity correlated with executive function, memory, concentration Carotid diameter correlated with executive function, visual spatial perception Causal relation between arterial alterations and cognitive performance could not be established in this study Powered by Infomedica 26th European Meeting on Hypertension and Cardiovascular Protection
26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 Arterial Alterations Contributed to Reduced Cognitive Function in Hypertension From ESH 2016 | POS 3C: Luiz Aparecido Bortolotto, MD, PhD Heart Institute, University of S o Paulo, Brazil Infomedica Conference Coverage* of 26th European Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 * Infomedica is an independent medical education provider that produces medical information to healthcare professionals through conference coverage and online educational programs and activities. Powered by Infomedica
