Comparison of Alcoholic vs Aqueous Chlorhexidine for Skin Antisepsis
Study comparing the efficacy of alcoholic vs aqueous chlorhexidine for preventing surgical site infections after minor skin excisions in general practice. Results show no significant difference in infection rates, indicating that aqueous chlorhexidine can be safely used with certain advantages.
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Presentation Transcript
Aqueous v Alcoholic Chlorhexidine for skin antisepsis Professor Clare Heal and Dr Daniel Charles
The Research Question Is the use of alcoholic chlorhexidine for skin antisepsis superior to aqueous chlorhexidine in preventing SSI after minor skin excisions in general practice?
Research Design and Method 4 general practices in North Queensland, Australia Prospective multicentre randomised controlled trial Consecutive patients minor skin excisions Intervention: 0.5% CHG in 70% alcohol Control: 0.5% CHG aqueous solution
What the Research Found Overall incidence infection 6.3% (57/909) 5.8% (26/451)(95%CI 3.4-7.6) alcoholic 6.8% (31/458) (95%CI 4.2-9.1) aqueous No significant difference in SSI p= 0.652 Absolute risk difference -0.9% [-0.021 to +0.039] NNT 112
What this means for Clinical Practice GPs can safely use aqueous chlorhexidine for skin antisepsis Aqueous has some advantages over alcoholic chlorhexidine Lower risk of: Mucosal irritation Dissolving surgical pen markings Operating room fires!
