Control Variables & Selectivity in DEKA Na+ Channel
"Explore the intriguing relationship between control variables, conductance, and selectivity in the DEKA Na+ channel. Discover how selectivity is intricately linked to channel diameter, while conductance is influenced by dehydration. Dive into the orthogonal nature of these variables and their impact on channel dynamics. Witness the unique interplay of structure, contents, and selectivity in shaping channel behavior. Unravel the complex yet fascinating mechanisms governing ion selectivity and conductance in biological systems."
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Presentation Transcript
Amazingly simple, not complex Control Variables Conductance of DEKA Na+channel Selectivity Depends Steeply on Diameter Selectivity depends only on diameter Contents and Selectivity Control Variables are Orthogonal* Amazingly, *Orthogonal: Selectivity depends only on Structure Conductance depends only on Contents, i.e., dehydration; i.e., dielectric) Selectivity depends not Conductance depends not on Structure on Contents, i.e., dehydration; i.e., dielectric) 1 Boda, et al
Na+ vs K+(size) Selectivity (ratio) Depends on Channel Size, not Dehydration (ProteinDielectric Coefficient)* Selectivity for small ion Na+2.00 K+ Na+ K+ 2.66 6 8 10 Small Channel Diameter Large in 2 Boda, et al *inDEKA Na Channel
Control Variables Conductance of DEKA Na+ channel Conductance Depends Steeply on Dehydration/Re-solvation (i.e., dielectric) Contents depend only on dehydration/re-solvation (dielectric) but Selectivity does not depend on Dielectric Selectivity depends only on Structure 3
Control Variable Channel Contents (occupancy) depends on Protein Polarization (re-solvation) DEKA Na Channel,6 Na+ 2.0 Occupancy K+ 2.66 Channel Contents occupancy protein protein 4 solvent = 80 Boda, et al
Static Structure Dynamic Structure Channel Diameter and Dielectric Coefficient emerge as Orthogonal Control Variables* in simulations of the Na channel, but not the Ca channel. *These emerge as outputs. They are not inputs. 5
