Curcumin-Loaded Hybrid pH-Sensitive Liposomes for Antineoplastic Activity
Discover the preparation and characterization of curcumin-loaded hybrid pH-sensitive liposomes for pleiotropic antineoplastic activity without toxicity to normal cells. Overcome disadvantages such as poor aqueous solubility and low bioavailability with promising results, including monomodal distribution and in vitro drug release profiles. Explore the cytotoxicity and conclude the potential of hybrid pH-sensitive liposomal nanoparticles for curcumin delivery.
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Presentation Transcript
PREPARATION AND CHARACTERIZATION OF CURCUMIN LOADED HYBRID pH-SENSITIVE LIPOSOMES Elena Drakalska, Denitsa Momekova, Budurova D.,Stanislav Rangelov, Nikolay Lambov
Introduction - Pleiotropic antineoplastic activity - Without toxicity to normal cells
Disadvantages -Poor aqueous solubility (11ng/ml) -Instability in physiological pH -Low bioavailability
Results - Monomodal distribution - Size app.180 nm - Zeta potential -20mV
In vitro drug release profile Figure 2. In vitro curcumin release from hybrid non pH sensitive (black) and hybrid pH-sensitive liposomes
Cytotoxicity - MTT- dye reduction assay - Panel of human cancer cell lines
Conclusion These findings give us a reason to conclude that the hybrid pH- sensitive liposomal nanoparticles are promising platforms for curcumin.
