Cutting-Edge Technologies and Innovations in Biotechnology
Discover Contignant Technologies, a leader in biotechnology advancements, offering increased performance in viromics, cost reduction strategies, and detailed insights into transcriptome assembly. Explore the impact on various scientific applications and advancements in genetic research. Contact founder Juanjo Bermúdez for more information.
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Presentation Transcript
Contignant Technologies SL https://contignant.com
Technology Overview 110% increased performance in viromics benchmark sets 64% increased performance in viromics for exceptionally large DNA viruses and phages
Cost reduction + better results Observed cost and metrics for different approaches sequencing a new fungi species
Melanoma transcriptome assembly statistics rnaSPAdes Megahit s-aligner (*) rnaSPAdes + Megahit rnaSPAdes + Megahit + s-aligner #contigs 26.609 17.066 45.485 --- --- #filtered matches to human RNA 78.642 72.824 72.462 --- --- Accumulated human RNA transcript length 25.941.124 bp 27.161.399 bp 15.202.695 bp 30.498.547 bp 31.326.381 bp Average completeness of transcripts 15,93% 17,04% 12,16% 17,55% 16,34% #Human transcripts partially assembled 40.015 39.706 30.413 42.805 46.203 #Unique transcripts 591 577 3.795 --- --- 2,7% increase in accumulated transcript length 8,5% increase in number of partial transcripts (*) Partial results for 1.900.000 reads
Melanoma transcriptome candidate mutations This is one of the 3.795 partial transcripts only found by s-aligner. We see in the image some candidate mutations in the sequence. The contig is 1410 bp long and corresponds to a variant of endothelin receptor type B (EDNRB) 7
More transcripts in an ALS sample transcriptome (I) S-aligner: rnaSPAdes: Megahit: NO RESULTS 8
More transcripts in an ALS sample transcriptome (II) S-aligner: rnaSPAdes: NO RESULTS Megahit: NO RESULTS 9
More transcripts in an ALS sample transcriptome (III) S-aligner: rnaSPAdes: Megahit: NO RESULTS 10
Contact Juanjo Berm dez Founder jbp@contignant.com
