Dietary Fiber Impact on Mineral Balance in CKD Rat Model
Explore the effects of dietary fiber fermentability and viscosity on mineral balance and gut microbiome in a rat model of CKD. Initial findings show potential benefits of psyllium on intestinal health. The study aims to further investigate mineral balance, CKD-MBD outcomes, and microbial metagenome. Funded by the Indiana Clinical and Translational Sciences Institute.
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Indiana Clinical and Translational Sciences Institute 2022 Annual Meeting The effects of dietary fiber based on fermentability and viscosity on mineral balance and the gut microbiome in a rat model of CKD Annabel Biruete, PhD, RD Department of Nutrition Science Purdue University
Heres what we found so far Study is ongoing with ~70% of animals done Psyllium seems to be increasing the length of the small intestine and the colon Weight trajectories were not different between groups Survival was similar between groups IMPROVING HEALTH THROUGH RESEARCH indianactsi.org
Heres how we are doing it IMPROVING HEALTH THROUGH RESEARCH indianactsi.org
Next steps Goals of my KL2 project is to expand on the effects of dietary fiber based on their viscosity and fermentability profile on: Mineral balance Other CKD-MBD outcomes The microbial metagenome and microbially-derived metabolites IMPROVING HEALTH THROUGH RESEARCH indianactsi.org
Grant Acknowledgement This project was funded with support from the Indiana Clinical and Translational Sciences Institute which is funded in part by Award Number KL2TR002530 from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. IMPROVING HEALTH THROUGH RESEARCH indianactsi.org
