DNA Replication Process in Anesthesia Techniques
Explore the intricate process of DNA replication discussed in the lecture by Dr. Mohammed Jasim Khulaif, detailing initiation, elongation, and termination steps. Discover how DNA polymerase, helicase, and ligase facilitate the synthesis of new DNA molecules. Gain insights into the essential role of origins of replication and Okazaki fragments in the replication process.
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Presentation Transcript
Department of Anesthesia Techniques Title of the lecture:- DNA Replication Dr Mohammed Jasim Khulaif Ph.D. Medical Microbilogy DNA Replication Replication is the process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules. Each strand of the double-stranded DNA molecule serves as a template for the synthesis of the new DNA molecule. DNA strands are antiparallel they have opposite directions The process of DNA replication, include three steps are initiation, elongation and termination.
Department of Anesthesia Techniques Title of the lecture:- DNA Replication Dr Mohammed Jasim Khulaif Ph.D. Medical Microbilogy Steps of DNA replication Initiation Begins at special sites along DNA called origins of replication where 2 strands open & separate making a replication fork DNA helicase breaks the hydrogen bonds between two DNA strands
Department of Anesthesia Techniques Title of the lecture:- DNA Replication Dr Mohammed Jasim Khulaif Ph.D. Medical Microbilogy
Department of Anesthesia Techniques Title of the lecture:- DNA Replication Dr Mohammed Jasim Khulaif Ph.D. Medical Microbilogy Elongation DNA polymerase (enzyme) responsible creating the new strand, adds new nucleotides to the exposed bases in the 5 to 3 direction On one strand called the leading strand (built toward replication fork) completed in one piece, new DNA is synthesized continuously. Lagging strand (built moving away from the replication fork) is made in sections called Okazaki fragments.
Department of Anesthesia Techniques Title of the lecture:- DNA Replication Dr Mohammed Jasim Khulaif Ph.D. Medical Microbilogy Termination DNA polymerase proofreads the new DNA checking for errors and repairing them; called excision repair DNA ligase(enzyme) helps join Okazaki segments together
