Drug Penetration Mechanisms through Skin Layers
Explore the pathways of drug penetration through the skin layers, including the role of the stratum corneum as the main barrier. Learn about Fick's first law of diffusion and how drugs permeate through intercellular and intracellular mechanisms.
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Presentation Transcript
(Dr.) Pranati Srivastava Asst. Professor School of Pharmaceutical Sciences, CSJMU, Kanpur
Hydrophilic drugs permeates by Intercellular pathway and Lipophilic drugs permeates by Intracellular(Transcellular) mechanism.
FICKS FIRST LAW OF DIFFUSION Percutaneous absorption of most drugs is a passive-diffusion process that can be described by Fick s first law of diffusion dQ/dt = JT= PA C JTis the total flux transported through a unit area of skin per unit time in steady state ( g/hr) Ais area of the skin Pis the effective permeability coefficient C is the drug concentration gradient across the skin
