Efficacy and Safety of Corticosteroid Implants for Uveitis Treatment
Explore the efficacy and safety of corticosteroid implants as an alternative treatment for chronic non-infectious uveitis. Two randomized controlled trials show that while fluocinolone acetonide implants may prevent uveitis recurrence, there are increased risks of cataract surgery and intraocular pressure-lowering surgery compared to standard care. After evaluating the benefits and harms, the superiority of implants over traditional systemic therapy remains inconclusive.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
You are allowed to download the files provided on this website for personal or commercial use, subject to the condition that they are used lawfully. All files are the property of their respective owners.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.
E N D
Presentation Transcript
Corticosteroid implants for chronic non-infectious uveitis Christopher J Brady, Andrea C Villanti, H Andrew Law, Ehsan Rahminy, Rahul Reddy, Pamela C Sieving, Sunir J Garg, Johnny Tang Issue 2, 2016 A presentation to: Meeting name Date Trusted evidence. Informed decisions. Better health.
Table of Contents 01 Background 02 Typesof studies 03 Key results 04 Tables (Risk of Bias/Forest Plots) 05 Conclusions 06 Acknowledgements
01: Background Uveitis, which many types of intraocular inflammatory diseases, is treated with corticosteroids Steroid implants are gaining ground as an alternative treatment Objective: To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis
02: Types of studies Participants Two randomized controlled trials, 619 eyes of 401 participants Interventions Fluocinoloneacetonide(FA) implants VERSUS Standard-of-care therapy
03: Key results a FA implant probably prevents recurrence of uveitis compared with standard-of-care therapy RR 0.29, 95% CI 0.14 to 0.59; 132 eyes increased risks of needing cataract surgery in the implant group compared with standard-of-care therapy RR 2.98, 95% CI 2.33 to 3.79, 371 eyes increased risks of needing surgery to lower intraocular pressure in the implant group compared with standard-of-care therapy RR 7.48, 95% CI 3.94 to 14.19, 599 eyes
04: Tables Cataract surgery through 24 months
04: Tables IOP-lowering surgery performed through 24 months
05: Conclusions After considering both benefits and harms reported from two studies in which corticosteroids implants were compared with standard-of-care therapy, we are unable to conclude that the implants are superior to traditional systemic therapy for the treatment of non-infectious uveitis.
06: Acknowledgements Cochrane Eyes and Vision US Satellite, funded by the National Eye Institute, National Institutes of Health Cochrane Eyes and Vision Editorial Base, funded by the UK National Health Service Research and Development Programme Christopher J Brady, Andrea C Villanti, H Andrew Law, Ehsan Rahminy, Rahul Reddy, Pamela C Sieving, Sunir J Garg, Johnny Tang Review citation Brady CJ, VillantiAC, Law HA, RahimyE, Reddy R, Sieving PC, Garg SJ, Tang J. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD010469. DOI: 10.1002/14651858.CD010469.pub2.
