Exploring CGTase and Cyclodextrins in Biochemistry
Explore the history and structure of CGTase enzymes, Bacillus strains, and cyclodextrins such as alpha-, beta-, and gamma-CDs. Learn about their applications in biochemistry and their unique cage and channel structures. Discover Stuart models, van der Waals interactions, and pH influences on CD properties.
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Presentation Transcript
Villiers ( cellulosine) 1891 bacillus amylobacter . 1903-1911 Schardinger - , - bacillus macerans . 1935 , 1935 Pringsheim CDs . 1948 -CD 32 CDs,
3 -CD 6 Schardinger's -dextrin -CD 7 Schardinger's -dextrin -CD 8 Schardinger's -dextrin -CD 9 , ,
Stuart models O , Lewis
H C2-OH C3-OH . -CDs 4 6 -CDs , -CDs C2-C3
CDs Cage structure Channel structure 2 CDs , guest molecules (head to head) (head to tail) 1 (cage type) CDs CDs 2 . CDs (herringbone fashion) (brick wall fashion)
CDs CDs -CDs [ -cyclodextrin 6H2O (I) , -cyclodextrin 7.5H2O] - CDs [ -cyclodextrin 12H2O , -cyclodextrin 11H2O ] - CDs [ -cyclodextrin 13H2O ] -CD6 20 2 4 -CD7.5 20 2 5.5 -CD11 2 6.12 4.88 -CD12 2 6.5 5.5 -CD13 2 5.3 7.7
CDs -CD -CD -CD
CGTase - - CGTase CGTases , , -CD (18,5 g / l) ( 25 C) - -CD (145 232 g / l ) ( , , )
2:1 1:3 ketoprofen - terpyridine HP- - :
: ) , ) , , ) , ) , ) ) ( ) . , .
- - (M -CD) . H CD , (2-HP- -CD) H heptakis (2,6-di-O-methyl)- -CD H hexakis (2,3,6-tri-O-acetyl)- -CD succinyl- -cyclodextrin Heptakis (2,6-di-O-methyl)- -CD hexakis (2,3,6-tri-O-acetyl)- -CD
, 1 2 CDs - , , , , ( )
cyclodextrin necklace / molecular necklace CDs (PEG) CDs (PEG-CD) van der Waals (PEG-CD) CDs , 0.1 NaOH
molecular necklaces STM (scanning tunneling microscope) images -CDs PEG NMR STM MoS2
Phatsawee Jansook, Thorsteinn Loftsson, CDs as solubilizers: Effects of excipients and competing drugs, International Journal of Pharmaceutics 379 (2009) 32 40 Villiers A., Sur la transformation de la f cule en dextrine par le ferment butyrique, Compt. Rend. Fr. Acad. Sci. 1891:435-8 Biwer A, Antranikian G, Heinzle E. Enzymatic production of cyclodextrins. Appl Microbiol Biotechnol 2002;59:609-17. M. Raoov ,S. Mohamad and M.Abas, Synthesis and Characterization of -Cyclodextrin Functionalized Ionic Liquid Polymer as a Macroporous Material for the Removal of Phenols and As(V), Int. J. Mol. Sci. 2014, 15 Sergey V. Kurkov, Thorsteinn Loftsson, Cyclodextrins Review, International Journal of Pharmaceutics 453 (2013) 167 180 E.M. Martin Del Valle, Cyclodextrins and their uses: a review, Process Biochemistry 39 (2004) 1033 1046 https://books.google.gr/books?hl=el&lr=&id=DZbpCAAAQBAJ&oi=fnd&pg=PR7&dq=cycl odextrin+scientific+papers&ots=rhf-YjYBZ9&sig=j_6ds7qQ- e3sT_3ay7_g6q6VsZw&redir_esc=y#v=onepage&q=cyclodextrin%20scientific%20paper s&f=false http://www.chemicalbook.com/ProductCatalog_EN/201273.htm
