Exploring Differential Gene Expression Patterns in Musculoskeletal Disorders
Uncover insights into upregulated and downregulated Single Cell Populations (SCPs) in musculoskeletal disorders using mouse models, patient data, and treatment databases. Discover how genetic expression changes play a role in response to treatments like baclofen, with visual data presented in detailed figures. Additionally, explore survival rates and morphometric measurements in different experimental conditions. Delve into the biomechanical aspects of circumferential stiffness, stress, and elastic energy in the context of musculoskeletal disorders.
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Presentation Transcript
A Upregulated SCPs in MFS mice -log10(p) B Upregulated SCPs in MFS patients -log10(p) Supplementary Figure 1
Downregulated SCPs after baclofen treatment in CMap database baclofen (experiment # 2036) A -log10(p) B Downregulated SCPs after baclofen treatment in CMap database baclofen (all experiments combined) -log10(p) Supplementary Figure 2
A Downregulated SCPs in WT mice +/- BAC -log10(p) B Downregulated SCPs in MFS mice +/- BAC -log10(p) Supplementary Figure 3
A 100 WT VEH MFS ENA ns 75 MFS PRO Percent Survival MFS VEH 50 25 0 0 30 60 90 Days After Birth B 0.25 0.30 0.20 0.25 AoR Diameter (cm) AsA Diameter (cm) 0.20 0.15 0.15 0.10 0.10 0.05 0.05 0.00 0.00 WT MFS MFS MFS WT MFS MFS MFS VEH VEH PRO ENA VEH VEH PRO ENA Supplementary Fig. 4
B C A 8 600 150 Circumferential Stiffness (MPa) 6 Circumferential Stress (kPa) Stored Elastic Energy (kPa) 400 100 4 200 50 2 0 0 0 WT MFS MFS WT MFS MFS WT MFS MFS VEH VEH BAC VEH VEH BAC VEH VEH BAC Supplementary Fig. 5
