Exploring Non-Genotoxic Cancer Mechanisms: AOPs and AhR Activation
Delve into the world of non-genotoxic cancer mechanisms through the exploration of Adverse Outcome Pathways (AOPs), sustained AhR activation leading to liver tumors, and more. Understand the potential predictive nature of LOGKW endpoints and the implications on cancer development.
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Presentation Transcript
Potential useful AOPs Non-genotoxic Cancer Narcosis LOGKW is predictive of endpoint
AOP41 Sustained AhR Activation leading to Rodent Liver Tumors AOP46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma AOP220 Cyp2E1 activation leading to liver cancer
A B Change to MAPK8
