Exploring Organo-Metallic Chemistry Insights
Delve into the fascinating realm of organo-metallic chemistry, understanding the definition, representation, ionic character, reactivity factors, and the significance of electropositive metal character in forming strong carbon-metal bonds. Discover the crucial role of organo-metallic compounds as nucleophilic agents and bases, and explore the synthesis and applications of Grignard reagents in organic synthesis.
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Presentation Transcript
Topic :- Organo-Metallic Chemistry Dr. Satish U. Deshmukh Department of Chemistry Deogiri College Aurangabad 1
Organo-Metallic Chemistry Definition :- Organic compounds that contain carbon- metal bonds are known organo-metallic compounds General represented :- R-M or R-M+ R = Organic compound M = Metal 2
Organo-Metallic Chemistry Ionic Character in % of Carbon-metal Bonds1 Ionic Character 70 60 60 52 C-Li 50 C-Mg C-Al 40 38 40 36 C-Zn 32 C-Pb 28 28 30 C-Cd 24 C-Sn 20 C-Cu C-Hg 10 0 C-Li C-Mg C-Al C-Zn C-Pb C-Cd C-Sn C-Cu C-Hg 4
Organo-Metallic Chemistry Generally, Organo-metallic compounds or Reagent are founds always act as a 1) Nucleophilic 2) Base Reactivity of organo-metallic compounds are mainly depends on Electro-Positve character of the metal. Tendency of an element to lose electrons and makes cations is known as an electropositive character. In a periodic table = Cesium and stable elements 5
Organo-Metallic Chemistry More is the Electropositive character of the metal is directly proportional to ionic character percentage of the Carbon-Metal (R-M) bond and thus more is the reactivity of organo-metallic Compounds. More % ionic character of R-M compounds more stronger was the ( powerful base) for example C-Li 6
Organo-Metallic Chemistry 1) Organo-Magnesium Reagent OR Organo-Magnesium Compounds Organo-Magnesium halides compounds ( R-Mg-X) or Reagent discovered in 1900 French Scientist, Victor Grignard Organo-Magnesium halides compounds are also known as Grignard reagents. This reagent has large exploit in organic synthesis to C-C bond. His was Awarded as Nobel Prize for Chemistry in the year of 1912 7
Organo-Metallic Chemistry R-X R-Mg-X Mg 8
Organo-Metallic Chemistry Synthesis of Grignard reagents 9
Organo-Metallic Compounds Structure of Grignard Reagents In dilute ether solution (0 1 M) Grignard reagents exist as monomers in which the magnesium is coordinated to two solvent molecules. 10
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Grignard reagents with compounds containing acidic hydrogen ( H-EN Group ) 11
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Alkynes react with Grignard reagents to produce hydrocarbons and new Grignard reagent. 12
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with formaldehyde 13
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with formaldehyde 14
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagents with aldehydes : 15
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagents with aldehydes : 16
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with Acetaldehyde 17
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with Acetaldehyde 18
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent With Acetone 19
Organo-Metallic Compounds Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with Acetone 20
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with unsaturated aldehydes 21
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with Imines: 22
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reactions Grignard reagent with Imines: 23
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reaction Grignard reagent with Nitriles: 24
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reaction Grignard reagent with nitrile 25
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reaction Grignard reagent With Carbon Dioxide, Sulphur Dioxide, Carbon Disulphide 26
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reaction Grignard reagent With Carbon Dioxide, Sulphur Dioxide, Carbon Disulphide 27
Organo-Metallic Chemistry Chemical Properties of Grignard reagents Nucleophilic Addition Reaction Grignard reagent with Nitriles: 28
Organo-Metallic Chemistry Nucleophilic Substitution Reactions at sp2-hybrid carbons Grignard reagent Reaction with Acid Chlorides, Esters, Lactones And amides. 29
Organo-Metallic Chemistry Nucleophilic Substitution Reactions at sp2-hybrid carbons Grignard reagent Reaction with Acid Chlorides, Esters, Lactones And amides. 30
Organo-Metallic Chemistry Nucleophilic Substitution Reactions at sp3-hybrid carbons and saturated atoms: Grignard reagent Reaction with Epoxide 31
Organo-Metallic Chemistry Thank you 32
