Factors Affecting Drug Bioavailability Through Dosage Form Selection
Explore the influence of dosage form related factors on drug bioavailability as discussed by Dr. Kalpana, Assistant Professor at the School of Pharmaceutical Sciences, CSJMU. The presentation covers the impact of nature and type of dosage forms, product age, storage conditions, pharmaceutical excipients, and manufacturing variables on drug performance and bioavailability.
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Presentation Transcript
Dosage form related factor affecting bioavailability Dr. Kalpana Assistant Professor School of Pharmaceutical sciences, CSJMU (29/4/22) 2-3 pm
Nature and Type of dosage form Apart from selection drug success also depends on selection of dosage form of drug Various formulations in decreasing order solution.> Emulsion>suspention> Capsule>Tablet> Coated tablet > Enteric Coated > Sustained release Absorption fromsolution is fastest to sustained to lowest. The variation is due to number of rate limiting steps. Rate limiting steps are dissolution, disintegration, deaggregation,dissolution, diffusion.
Product age and storage conditions Ageing causes changes in physicochemical properties of drugs As a resut affects bioavailability Eg Precipitation, polymorphism ( metastable to stable form), change in particle size etc. Echanges occur during shelf life are mainly affected by temperature and humidity. Eg: prednisolone with lactose make tablet harder CMC in tablets causes softenin of tablet during storage. PVP as excipient causes hardening of tablet.
Pharmaceutical Excipients formulation factors) Drugs never administered single they are converted to dosage form by using excipients. Selection of excipients is important It affects performance of product. Excipients like Fillers Binders Granulating agents Lubricants Coating Suspending agents Surfactants Buffers Complexing agents
Manufacturing variable Manufacturing dissolution from dosage form. Eg tablet method of compression direct compression Granulation technology Compression force As it affects disintegration time, dissolution of product process influence drug density, porosity, hardness,
Reference Text book of Biopharmaceutics and pharmacokinetics ; Brahamankar and Jaiwal
