Fascinating Insights into Memory Neurobiology
Unveil the intricate world of memory neurobiology through discussions on amnesias, the critical role of the hippocampus in memory formation, place cells, grid cells, and head direction cells. Explore how brain damage affects memory and dive into the fascinating case of H.M., showcasing the importance of understanding memory disorders. Discover the complexities of neuronal firing patterns and the interactions between different brain regions involved in spatial mapping and memory processing.
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Presentation Transcript
Memory neurobiology CS786 Mar 29th2022
Amnesias = memory disorder Retrograde amnesia Cannot remember events prior to brain damage Anterograde amnesia Cannot later remember events that occur after brain damage Brain damage occurs time
A fortuitous discovery H.M. suffered from epilepsy from a young age Operated upon for treatment Post-op presented with a pure case of anterograde amnesia Demonstrated criticality of hippocampus for memory formation https://www.newyorker.com/books/page-turner/the-man-who-forgot-everything
Hippocampus Phenomenally interesting anatomical structure; crucial for forming representations
Place cells Firing patterns of 8 place cells recorded from CA1 in a rat
Hippocampus Phenomenally interesting anatomical structure; crucial for forming representations
Grid cells Like place cells, but embed Euclidean space assumptions Encode spatial firing fields at equal distances from neighbors As if neurons are sensitive to an underlying triangular coordinate system Red dots indicate location of rat in physical space when the grid cell fires
Hippocampus Phenomenally interesting anatomical structure; crucial for forming representations
Head direction cells Fire when animal s head turns in a particular direction Tend to lead the actual head movement by about 100 ms HD system interacts with place cells to generate spatial map of environment? Operates coherently during REM sleep
