Genotypes Circulating in the NIS Region - Measles Data Analysis

The data presents multiple genotypes circulating in the NIS region, specifically focusing on measles incidence and genotypes in Russia for the years 2014 and 2015. The information includes the number of measles cases, genotyping data availability, and specific genotypes identified in different countries within the NIS region. The data sheds light on the epidemiological situation, genotyping variations, and trends associated with measles in this geographical area.

• Genotypes
• NIS Region
• Measles Incidence
• Russia
• Genotyping Data

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1. Multiple genotypes circulating in the NIS region WHO Euro Regional Reference Laboratory for Measles/Rubella, G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia

2. Measles incidence, NIS,2015 Country Number of measles cases 2015 0 Genotyp ing data avail. Azerbaijan 33 + Armenia 2 + Belarus 0 Moldova 2341 + + Kazakhstan 21343 Kyrgyzstan 843 + Russia 3 ? Tajikistan 0 Turkmenistan 105 ? Ukraine Measles incidence, cases/1 mln. of pop. 22 + Uzbekistan 0; < 1; 1 5; 5 15; >100; > 3000

3. Measles incidence and genotypes, Russia, 2014 350 4711 cases, 32,4/1000000, D8 301 (10 gen. variants) D4 Az - 11 D4 MVs/Manchester.GBR/10.09 4 B3 - 12 H1 2 G3 1 112 imp. cases 29 countries 300 250 Number of cases 200 150 100 50 0 1 2 3 4 5 6 7 8 9 1011121314151617181920212223242526272829303132333435363738394041424344454647484950515253 Week 25 20 Number of strains 15 D8 Chui first isolation 10 5 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 192021 222324252627282930 31 32333435363738394041 424344454647484950 51 5253 Week G3 D8Hokk D8RoD B3Lond D4M D8Gadag.IND D8Tbilisi H1 HK12 D4Az D8BO D8 Karaj.IRN H1 HK11 D8V D8F B3H D8 Chui D8VPret D8RoK B3Torn Genotype

4. Measles incidence and genotypes, Russia, 2015 60 843 cases, 0,58/1000000, D8 205 (7 gen. lineages) D8Chui - 115 H1 15 (2 gen. lineages) B3 - 1 50 40 Number of cases 30 20 10 Week 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 192021 22232425262728293031 32333435363738394041 424344454647484950 51 5253 25 20 Number of strains 15 D8 Chui last isolation D8 RoK last isolation 10 6 2 2 7 5 1 2 2 1 3 1 1 1 1 1 1 1 0 Week 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 192021 222324252627282930 31 32333435363738394041 424344454647484950 51 5253 Genotype D8F D8RoK D8RoD D8Chui D8V D8Victoria D8HL H1 HK11 H1 HK12 B3Kansas

5. Measles genotypes, NIS, 2015 MVs/South Kazakhstan.KAZ/5.15/4 5734 MVi/Villupuram.IND/03.07/ Named strain MVs/South Khazakhstan.KAZ/5.15/3 5733 MVs/South Khazakhstan.KAZ/5.15/2 5732 MVs/South Kazakhstan.KAZ/5.15/ MVs/South Kazakhstan.KAZ/4.15/ 5731 MVs/South Khazakhstan.KAZ/3.15/2 5730 MVs/Shymkent City.KAZ/11.15/ MVs/North Khazakhstan.KAZ/11.15/ 5743 MVs/Akmola.KAZ/9.15/ 5740 MVs/Akmola.KAZ/7.15/ 5738 MVs/Tashkent.UZB/7.15 Imp. Kazakhstan/ MVs/Tashkent.UZB/5.15Imp. Kazakhstan / MVs/Aragats.ARM/35.15/2 5920 MVs/Aragats.ARM/35.15/ 5919 MVs/Chui.KGZ/2.15/ 5582 MVs/Bishkek.KGZ/1.15/2 5557 MVs/Bishkek.KGZ/2.15/ 5572 MVs/Bishkek.KGZ/2.15/2 5579 MVs/Bishkek.KGZ/2.15/3 5580 MVs/Talas.KGZ/4.15/ 5594 MVs/Talas.KGZ/4.15/2 5596_ MVs/Talas.KGZ/6.15/ 5600 MVs/Talas.KGZ/6.15/2 5602 MVs/Tashkent.UZB/30.15/ 5849 MVs/Chui.KGZ/53.14/ Named strain Kyrgyzstan 21343 rep. cases D8 MVs/Chui.KGZ/53.14/ MVi/Villupuram.IND/03.07/ Uzbekistan 22 cases D8 (2 seq. var. linked to Kaz. outbreak, + 1 linked to Kyrgyzstan?) Named strain Named strain Armenia 33 cases D8 Kazakhstan 2341 cases D8 (5 seq, var. 3 gen. lin.) B3 MVs/Akmola.KAZ/8.15/ 5739 MVs/Republic of Komi.RUS/35.13/[D8] 3884 Named strain MVs/North Kazakhstan.KAZ/18.15/ 5745 MVs/Frankfurt Main.DEU/17.11/ Named strain MVs/Tashkent.UZB/30.15/2 Imp. Kazakhstan MVs/Tashkent.UZB/30.15/3 Imp. Kazakhstan MVs/Pretoria.ZAF/19.09/ MVs/Petropavlovsk.KAZ/22.15/2 MVs/South Khazakhstan.KAZ/3.15/ 5729 MVs/Sohar.OMN/23.12/ Manchester.UNK/30/94_D8 Edmonstonwt.USA/54_A NewYork.USA/94_B3 Ibandan.Nie/97/1 B3 MVs/Kansas.USA/1.12/2 Named strain Imp Ethiopia MVs/North Khazakhstan.KAZ/17.15/ 99 99 99 99 99 97 5

6. Kyrgyzstan and linked ases in Russia MVs/Tyumen.RUS/4.15/ Imp. Kyrgyzstan MVs/Tyumen.RUS/11.15/ Imp. Kyrgyzstan MVs/Stavropol.RUS/19.15/ Imp. Kyrgyzstan MVs/Republic of Dagestan.RUS/20.15/ Imp. Kyrgyzstan MVs/Ufa.RUS/16.15/ Imp. Kyrgyzstan MVs/Novosibirsk.RUS/19.15/ Imp. Kyrgyzstan MVs/Moscow.RUS/17.15/ Imp. Kyrgyzstan MVs/Moscow.RUS/16.15/8/ Imp. Kyrgyzstan MVs/Moscow.RUS/16.15/5 Imp. Kyrgyzstan MVs/Moscow.RUS/16.15/3 Imp. Kyrgyzstan MVs/Moscow.RUS/15.15/4 Imp. Kyrgyzstan MVs/Moscow.RUS/12.15/6 Imp. Kyrgyzstan MVs/Moscow.RUS/10.15/2 Imp. Kyrgyzstan MVs/Krasnoyarsk.RUS/11.15/ Imp. Kyrgyzstan MVs/Irkutsk.RUS/25.15/3 Imp. Kyrgyzstan MVs/Irkutsk.RUS/25.15/2 Imp. Kyrgyzstan MVs/Ulan-Ude.RUS/23.15/ Imp. Kyrgyzstan MVs/Ivanovo.RUS/8.15/ Imp. Kyrgyzstan MVs/Talas.KGZ/6.15/2 5602 MVs/Talas.KGZ/6.15/ 5600 MVs/Talas.KGZ/4.15/2 5596_ MVs/Talas.KGZ/4.15/ 5594 MVs/Bishkek.KGZ/2.15/3 5580 MVs/Bishkek.KGZ/2.15/2 5579 MVs/Bishkek.KGZ/2.15/ 5572 MVs/Bishkek.KGZ/1.15/2 5557 MVs/Chui.KGZ/2.15/ 5582 MVs/Chui.KGZ/53.14/ Named strain MVs/Chelyabinsk.RUS/53.14/ Imp. Kyrgyzstan MVs/Bishkek.KGZ/53.14/ 5553 MVs/Chui.KGZ/53.14/2 5558 MVi/Villupuram.IND/03.07/ Named strain MVs/Chui.KGZ/23.14/ Imp. Kazakhstan MVs/St.Petersburg.RUS/19.15/ Imp. Kyrgyzstan Russia 2015 Kyrgyzstan linked cases Kyrgyzstan 2015 100 2014 Manchester.UNK/30/94_D8 Edmonstonwt.USA/54_A 5

7. Russia, measles 2016 Number of cases MVs/Republic of Buriatia.RUS/7.16/2/ 6036.4 MVs/Liaoning.CHN/13.14/2 Region Moscow R. of Tatarstan Ingush Republic North Osetia R. Of Chechnya Rostov on Don Irkutsk Stavropol R. of Buryatia Russia Jan 1 1 Feb 1 Mar Apr Total 2 1 2 2 5 1 1 4 4 MVs/Republic of Buriatia.RUS/7.16/ 6036.2 MVs/Irkutsk.RUS/21.16/ 6130 MVs/Irkutsk.RUS/20.16/2/ 6128 MVs/Irkutsk.RUS/20.16/ Linked to China MVs/Hong Kong.CHN/49.12/ H1 Named strain MVs/Republic of Buriatia.RUS/15.16/ 6082 MVs/Republic of Buriatia.RUS/18.16/2/ 6106 2 1 1 4 1 1 91 1 2 2 1 9 99 2 4 1 5 MVs/Ulaanbaatar.MNG/44.15/ 22 4 MVs/Republic of Buriatia.RUS/18.16/ 6104 MVs/Shandong.CHN/13.15/18 99 MVs/Hong Kong.CHN/42.11/ Named strain Hunan.CHN/93/7_H1 Edmonstonwt.USA/54_A MVs/Republic of Tatarstan.RUS/4.16/ Imp. India MVs/Faridabad.IND/22.14/ Manchester.UNK/30/94_D8 MVs/Perm.RUS/3.16/ Imp. Kazakhstan MVi/Villupuram.IND/03.07 Named strain / 99 91 99 MVs/Ingush Republic.RUS/17.16/ 6119 MVs/Frankfurt Main.DEU/17.11/ Named strain MVs/Lipetsk.RUS/22.16/ Linked to R.of Chechnya MVs/Moscow.RUS/17.16/ 6085 MVs/Rostov-on-Don.RUS/17.16/ 6114 MVs/Rostov-on-Don.RUS/17.16/2/ 6116 MVs/Rostov-on-Don.RUS/19.16/ 6117 80 99 5

8. Summary Measles incidence linked to virus importation that results in different scenarios (from sporadic cases to nation-wide outbreaks); Multiple introduction of the virus + pockets of susceptible (unvaccinated adults and young infants, Roma pop., religious groups) sustain prolonged transmission; Predominance of different D8 measles lineages with origin outside of the NIS region and simultaneous transmission of many different sequence variants of the virus observed.

9. Thank you!

10. Extra slides

11. Rubella incidence, NIS,2015 - 2016 Country Numb er of cases 2015 0 Genotyp ing data avail. Number of cases, Russia 2016 (Jan Apr) Azerbaijan 0 Armenia* Region Archangelsk St. Petersburg Moscow Yaroslavl Orel Kursk Krasnodar Stavropol Russia Jan 0 0 1 4 1 0 0 2 8 Feb 0 1 1 7 0 0 0 0 9 Mar 2 0 0 3 0 0 1 0 6 Apr 0 0 2 9 0 1 0 0 12 Total 2 1 4 23 1 1 1 2 35 1 ? Belarus 0 Moldova 2 ? Kazakhstan 101 ? Kyrgyzstan 25 + Russia 1 ? Tajikistan 0 Turkmenistan 248 ? Ukraine 0 Uzbekistan

12. Rubella genotypes, Russia, 2014 - 2016 RVs/Yaroslavl.RUS/13.16/ 6066 RVs/Yaroslavl.RUS/16.16/ 6099 Outbake 28 cases Oct 2015 - May 2016 Unknown source RVs/Yaroslavl.RUS/12.16/ 6069 RVs/Yaroslavl.RUS/11.16/ 6062 RVs/Yaroslavl.RUS/03.16/ 6009 RVs/Orel.RUS/53.15/ 6002 Strains 2015 RVs/Zongo.COD/13.13/ 100 RVs/Kinshasa.COD/23.12/ Strains 2016 RVs/Novgorod.RUS/13.15/ 5375 Outbreak 6 cases African students Feb Mar 2015 Unknown source 97 RVs/Novgorod.RUS/13.15/2 5377 88 RVs/Moscow.RUS/22.16/ 6132 RVs/Florida.USA/04.16/ Imp.India 95 RVs/Astrakhan.RUS/10.14/ 4z175/1 RVi/Kedah.MYS/05.14/ RVi/Kelantan.MYS/05.14/ 99 RVs/HongKong.CHN/49.08 99 RVs/Astrakhan.RUS/03.14/ 4859 RVs/Astrakhan.RUS/16.14/ 4z995 RVs/Astrakhan.RUS/16.14/2 4z998 RVs/Astrakhan.RUS/01.15/CRS 5027 Rvi/Seattle.WA.USA/16.00[2B] RVi/TelAviv.ISR/68[2B] RVi/BEL/63[1a] RVi/Dezhou.CHN/02[1E] RVi/North Carolina.USA/15.11/[1E] Imp Indonezia 100 97 RVs/Moscow.RUS/17.14/ 4z830 99 RVs/Samara.RUS/27.14/ 4N829 97 5

13. Summary Rubella in Russia is not endemic, very limited data for other countries.