Glyphosate as Glycine Analogue: Understanding the Impact on Protein Synthesis
Explore the potential implications of glyphosate acting as a glycine analogue in protein synthesis, potentially leading to disruptions in enzyme function and contributing to various chronic diseases. Understand the correlation between glyphosate usage and conditions such as obesity, diabetes, Alzheimer's disease, cancer, kidney failure, and Parkinson's disease.
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Presentation Transcript
Glyphosate as Glycine Analogue: Explaining Zika & Microcephaly Stephanie Seneff U.S. Congressional Hearing June 14, 2016
What If Glyphosate Could Insert Itself Into Protein Synthesis??? glyphosate Code for glycine GGC . . . mRNA . . . Glyphosate Alanine Proline Any proteins with conserved glycine residues are likely to be affected in a major way
Extra Piece Sticks Out at Active Site Substrate no longer fits in active site Active Site Extra Stuff Glyphosate Proline Alanine Peptide chain glycine
Extra Piece Sticks Out at Active Site Substrate no longer fits in active site Active Site Extra Stuff This explains how glyphosate suppresses the enzyme EPSPS in the shikimate pathway Glyphosate Proline Alanine Peptide chain glycine
Vulnerable Proteins: Resulting Pathologies Conserved Glycines Disease Profile Hormone-sensitive Lipase Obesity Insulin Receptor Diabetes Amyloid Beta Plaque Alzheimer s Disease DNA Damage Cancer OGG1 Lipocalin Kidney Failure ACTH Adrenal Insufficiency Cytochrome C Oxidase Mitochondrial Disease Alpha Synuclein Parkinson s Disease TDP-43 ALS
Vulnerable Proteins: Resulting Pathologies Conserved Glycines Disease Profile Hormone-sensitive Lipase Obesity Insulin Receptor Glyphosate insertion by mistake in place of glycine during protein synthesis can easily explain the alarming correlations between glyphosate usage on core crops and a long list of debilitating chronic diseases Diabetes Amyloid Beta Plaque Alzheimer s Disease DNA Damage Cancer OGG1 Lipocalin Kidney Failure ACTH Adrenal Insufficiency Cytochrome C Oxidase Mitochondrial Disease Alpha Synuclein Parkinson s Disease TDP-43 ALS
Zika and Molecular Mimicry Studies from the Vaccine Induced Immunological Damage (VIID) Program Zika E Protein: GWGNGCGLFGKGSLV Immunoglobulin heavy chain: Lots of glycines! These could get displaced by glyphosate during protein synthesis!! Likely to disrupt protein folding and cause resistance to breakdown Autoimmune reaction to similar protein (immunoglobulin heavy chain) due to molecular mimicry GYSSGCGYWGQGTLV
GMO Mosquito* Grown in contained spaces in Cayman Islands Fed sucrose as larvae followed by blood as adults (sucrose comes from sugar beets or sugar cane) Males engineered to become infertile without access to tetracycline They could be harboring more glyphosate than mosquitoes in the wild *AF Harris et al., Nature Biotechnology 2011; 29:1034-1037.
GMO Mosquito* Grown in contained spaces in Cayman Islands Fed sucrose as larvae followed by blood as adults (sucrose comes from sugar beets or sugar cane) Males engineered to become infertile without access to tetracycline They could be harboring more glyphosate than mosquitoes in the wild A Zika virus growing in a GMO mosquito is likely to end up with glyphosate in its proteins *AF Harris et al., Nature Biotechnology 2011; 29:1034-1037.
Very low levels of immunoglobulins are linked to a condition that includes immune deficiency, neurological abnormalities, failure to thrive and microcephaly* *ME Conley et al., Blood 1986;67(5):1251-1256.
