Hydrocortisone Release Comparison: Serum and Salivary Cortisol Levels
Compare the effects of immediate vs. modified release hydrocortisone on serum and salivary cortisol levels throughout the day. Analyze the calculated free serum cortisol levels and their implications. Explore the results in a comprehensive study, including data visualizations for better understanding.
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Presentation Transcript
4000 A 3500 immediate release hydrocortisone Serum-Cortisol (nmol/l) 3000 2500 2000 1500 1000 500 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 B 4000 3500 modified release hydrocortisone Serum-Cortisol (nmol/l) 3000 2500 2000 1500 1000 500 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 Figure 1
A 140 immediate release hydrocortisone 120 Calculated free serum cortisol (nmol/l) 100 80 60 40 20 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 B 140 modified release hydrocortisone 120 Calculated free serum 100 cortisol (nmol/l) 80 60 40 20 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 Figure 2
160 Calculated free serum cortisol (nmol/l) A 140 120 100 immediate release HC 80 modified release HC 60 40 20 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 B Calculated free serum cortisol (nmol/l) 160 140 120 100 20mg-10mg-0 10mg-10mg-0 80 10mg-5mg-0 60 healthy controls 40 20 0 6:00 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 Figure 3
1400 1200 Salivary Cortisol (nmol/l) 1000 800 immediate release HC modified release HC 600 400 200 0 7:30 8:00 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 Figure 4
