IAS Towards an HIV Cure
An initiative led by Sharon R. Lewin and Sunnylands to develop and ensure access to an HIV cure, particularly in Sub-Saharan Africa. Discussions on the landscape of HIV treatments, target populations, and the Target Product Profile for alignment among stakeholders.
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IAS Towards an HIV Cure Sharon R Lewin AO, FRACP PhD FAHMS Co-chair, Scientific Advisory Board, IAS Towards a Cure www.iasociety.org
Sunnylands initiative for an HIV cure IAS Cure Research Academies www.iasociety.org
The Annenberg Trust at Sunnylands is an independent nonpartisan, nonprofit organization dedicated to convening global leaders in the public and private sectors to promote world peace, facilitate international agreement, and seek solutions to the most daunting challenges facing the world today. www.iasociety.org
Host: IAS in partnership with the Annenberg Trust at Sunnylands Objective: To consider what it will take to develop and ensure the widest possible access to a cure for HIV, specifically in sub-Saharan Africa. Sunnylands Retreat Feb 2019 Goals: To align on a Target Product Profile for an HIV Cure To agree what it will take to ensure that a cure with this profile is widely accessible to the largest number of people in sub-Saharan Africa. www.iasociety.org
What we discussed? www.iasociety.org
Current and future landscape for HIV cART Long-acting ART We are here Broadly neutralizing antibodies First generation Second generation Third generation Daily treatment modalities Long acting treatment modalities Single shot cure Cure modalities 2019 20?? 20?? 20?? 20?? www.iasociety.org
Target populations to consider diagnosed not treated suppressed on ART not at risk viremic on ART diagnosed www.iasociety.org
Target Product Profile (TPP) Help to align all stakeholders by broadly defining the regimen or product the community wants to deliver to the field Form the north star and define the minimally-acceptable and optimistic interventions Will evolve based on breakthrough scientific developments and changing patient needs www.iasociety.org
Towards a public private partnership for an HIV Cure: HIV Cure Acceleration of Africa (HCAAP) is a public private partnership established to drive and coordinate end- to-end progress towards the goal of an HIV cure across all relevant stakeholders www.iasociety.org
Next steps and timelines Co-chaired by Dr. Sharon Lewin and Dr. Steven Deeks Q2 2020: Publish TPPs and determine long- term maintenance strategy Q4 2019: Socialize TPPs broadly including ICASA 2019 Q1 2020: Conduct Delphi exercise to finalize TPPs TPP WG established Q3 2019: Draft cure TPPs complete We are here 2019 2020 Q4 2019: Socialize HCAAP concept broadly including ICASA 2019 Q3 2019: Draft concept note complete + F2F meeting Q1-2 2020: Seek funding for HCAAP HCAAP WG established Co-chaired by Dr. Izukanji Sikazwe and Dr. Mark Dybul www.iasociety.org
Acknowledgements Bill & Melinda Gates Foundation Cathy Bansbach Timothy Attoye Adam Jiang Mike McCune Sunnylands working group Mark Dybul Rosanne Lamplough Ellen LaPointe Sharon Lewin Steve Deeks Mike McCune Joe Tucker Wendy Wertheimer The Annenberg Foundation Trust at Sunnylands Rob Fallon David Lane McKinsey & Company Matt Craven Matt Wilson International AIDS Society Rosanne Lamplough Roger Tatoud www.iasociety.org
Research-for-Cure Academy www.iasociety.org
Research-for-Cure Academy 7-9 November 2019 Wits Rural Facility, South Africa Are you an early to mid-career HIV investigator or clinical scientist? Are you affiliated with or working in collaboration with an institution or university in a resource-limited country? Are you interested in pursuing HIV cure research? Deadline for applications: 12 August www.iasociety.org
Advocacy-for-Cure Academy In partnership with: www.iasociety.org
Advocacy-for-Cure Academy 29 April 1 May 2019 Botswana Objectives: Provide training and skills building on current HIV cure research strategies, barriers to a cure, and communicating scientific results accurately, especially to communities. Develop translational tools to disseminate information to the wider community, including policy makers, the media and programme managers. Create opportunities to interact with leading researchers and advocates in the field with a view to expanding the network of advocates working in HIV cure. In partnership with: www.iasociety.org
