Impact of Nanoparticles on Nanodosimetry and Radiochemistry
Goals of the study include estimating and understanding nanodosimetry, increasing local radiation dose, modifying water radiolysis, enhancing cell killing, and integrating with NanoxTM for cellular death probability calculations. The project aims to explore the effects of nanoparticles on various radiobiological aspects, utilizing a multi-scale dosimetry approach to investigate physical and chemical events at different scales.
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Presentation Transcript
Simulation l'chelle atomique de l'impact des nanoparticules d'or sur la dosim trie : premiers r sultats (Projet Biohydra) Michael Beuve et al. M. Beuve, AG MI2B - Sept. 2015, Marseile
LQD-PHYCHEML-CHEM Physics > Physico-Chemistry -> Chemistry Irradiation of liquid water With ions, electrons and photons C 175 KeV/ m 10-6 s Created at CIMAP in 1997 (CEA/CNRS) Olivera et al. Phys Med. Biol. 1998 M. Beuve, AG MI2B - Sept. 2015, Marseile 2
Some examples of studies Multi-ionisation Production de HO2/O2- GerGervais vais et al. Chem. Let.2005 et al. Rad Phys Chem 2006 Galassi et al. ICPEAC 2015 CIMAP IFIR (Argentina) IPNL Univ. of Wisconsin Ouerdane et al. JPC 2010 CIMAP IPNL IRAMIS Water Nano pore in silica Nano particle of silica in water Colliaux et al. J Phys: Conf. Serie (2010) Colliaux et al. NIMB (2015) IPNL LRCM Impact of dissolved O2and antioxidant (GSH) Beuve et al. NIMB 2009 Beuve et al. RadRes 2009 Chaikh et al. J. of Nanomed. 2015 Chaik et al. Int. J. Cancer. The. Onc. 2015. Nanodosimetry and microdosimetry IPNL LPC-Clermont, Univ. of J. Fourrier CIMAP IPNL IRAMIS Impact on water radiolysis of HBR and dissolved O2 M. Beuve, AG MI2B - Sept. 2015, Marseile
Impact of nanoparticle : Goals Estimate / Understand: Nanodosimetry Increase of local dose Radiochemistry Modification of water radiolysis Radiobiology Increase of cell killing Coupling the simulation with NanoxTM To calculate the probability of cell killing M. Beuve, AG MI2B - Sept. 2015, Marseile
NanoxTMModel Nanox = NANodosimetry and OXidatif Stress => Prediction of cell-killing for hadrontherapy Proton, Carbon Statistical physics ?= ??,? Issued from fundamental research Basic postulates, Simplifications Approximations => Evolution potential Test of scenarios Based on multi-scale dosimetry Macro, Micro, NANo scale Physical events, but also chemical (OXidative stress) Inputs : Monte-Carlo Energy deposition But also radical production M. Beuve, AG MI2B - Sept. 2015, Marseile
Nano and NanoxTM MDM NanoxTM NanoxTM M. Beuve, AG MI2B - Sept. 2015, Marseile
GNP: Funding, partners , collaborators IE : O. Rey Collaboration tools Fusion LQD + MDM Auger description Biohydra : PhysCancer CIMAP A. Domaracka, B.Gervais IPNL Post-doc: Prof. A. Ipatov Gold description Test M. Beuve, A. Ipatov + LCP C. Sicard) Training student: T. Bacle (Sup. C. Monini) Prelinary results LabEx Primes IPNL M. Beuve, F. Poignant, E. Testa LPC CLERMONT G. Montarou, O. Rey + Other partners (Experimental) Ph-D : F. Poignant Evaluation, result Coupling with nanox Other nanoparticles M. Beuve, AG MI2B - Sept. 2015, Marseile
Ingredients Water Gold Ionisation of molecules Excitation of molecules Auger relaxation Electron attachment Electron-hole recombination Elastic diffusion Electron-phonon collision Plasmon excitation Bulk plasmon solid => Depending of size Ionisation Atomic description Elastic diffusion Electron-phonon collision Gold water interface : electron affinity M. Beuve, AG MI2B - Sept. 2015, Marseile
Materials & Methods Uniform irradiation System: a GNP in A large water box Particle Mono energetic X-rays Compton & photo-electric Irradiation modality: Uniform irradiation Equilibrium of charged particles Clear definition of macroscopic dose in water Not just a ionisation of one atom!!! Water Outcome : DER Dose Enhancement Ratio Radial dose Spherical shells cantered on the nanoparticle M. Beuve, AG MI2B - Sept. 2015, Marseile
Preliminary results Details GNP Radius: 0.95, 25, 50nm X-ray : 60keV < EK(80.6KeV) Dose : 1 Gray Shell thickness 5nm Box size: 15 and 77 m Results 0,95nm: no enhancement 25-50nm: Clear enhancement Higher close to the GNP Higher for the largest GNP (DER> 25) Fast decrease : low DER beyond 400nm Larger range for the largest GNP radius M. Beuve, AG MI2B - Sept. 2015, Marseile
Preliminary results Details GNP Radius: 0.95, 25, 50nm X-ray : 82keV > EK(80.6KeV) Dose : 1 Gray Shell thickness 5nm Box size: 15 and 77 m Results Similar observations Higher DER (>30) M. Beuve, AG MI2B - Sept. 2015, Marseile
Conclusions / Outlook Simulations Atomistic accuracy Realistic system / some work in literature Preliminary results Clear dose enhancement (up to x30) Higher for the largest GNP and photon energy Outlook Keep testing Exhaustive production of results Nanodosimetry / radiochemistry Coupling with nanox Other nanoparticle: Iron, Gadolinium (LabEx PRIMES), Carben M. Beuve, AG MI2B - Sept. 2015, Marseile
