Impact of Telephone Calls on Participant Retention in a Clinical Trial
Explore the effects of regular phone calls from a coordinating center on participant retention in a randomized clinical trial conducted by the DRCR Retina Network. Despite ~30,000 participant calls, the study found that these calls did not significantly enhance long-term participant retention.
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DRCR Retina Network Effect of Telephone Calls From a Centralized Coordinating Center on Participant Retention in a Randomized Clinical Trial (Protocol S) Supported through a cooperative agreement from the National Eye Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health, Department of Health and Human Services EY14231, EY14229, EY018817 1
Background The DRCR Retina Network coordinating center regularly contacts participants via phone to encourage retention Typically, contacts are made at baseline and every 6 months during a study Since its inception the DRCR has made ~30,000 participant calls. 2
Purpose Within a multi-center clinical trial do regular phone calls to participants from a coordinating center improve long-term participant retention? 3
Methods In DRCR Protocol S (PRP vs Ranibizumab for PDR) participants received routine phone calls from the Coordinating Center either as an Annual Contact: baseline, 6 months, and annually thereafter Baseline Contact: baseline only All participants could be contacted if visits were missed. Main outcomes: visit completion, excluding deaths, at 2 years (the primary outcome time point) and at 5 years (the final time point). 4
Baseline Participant Characteristics Annual Contact N = 152 Baseline Contact N = 153 Treatment Group Bilateral Ranibizumab Prompt PRP Female Sex Non-White Race/Ethnicity Type 2 Diabetes Median HbA1c, % Median Age, years 30% 33% 37% 46% 48% 74% 8.7 53 28% 34% 38% 42% 47% 78% 8.5 51 5
Visit Completion by Frequency of Contact 100 90 89 88 87 Completion Percentage* 78 75 80 72 69 67 66 60 40 20 0 1 Year 2 Years P = .81 3 Years 4 Years 5 Years P = .93 Annual Contact *Excluding deaths Baseline Contact 7
Conclusions Regular phone calls from a coordinating center to participants during follow-up in this randomized clinical trail did not improve long- term participant retention. 8
