Insights into MESA Virtual Updates and Study Outlines
Explore the latest updates from MESA Virtual, including details on study outlines, acknowledgments to teams, and effective strategies during the COVID era. Dive into the Multisite MESA-MIND Study and learn about cognitive testing, brain MRI, and more across multiple sites. Discover key elements such as informant modules, proxy roles, and the impact of COVID on data collection strategies.
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Presentation Transcript
Updates MESA Virtual SC June 29, 2020
Updates Visit A (2019-2021) COVID-19 delays and restart Outline MESA Memory & MIND Next Steps
Acknowledgments to MESA-MIND Teams MESA Ancillary and Steering Committees MESA MIND Site PIs, Coordinators, and Staff MESA Coordinating Center WFU NeuroCog Team MIND Adjudication Committee MESA MRI Center MESA PET Center MESA PWV Lab Most importantly, our dedicated MESA Participants!
Multisite MESA Multisite MESA- -MIND Study (R01AG058969 MPI: Hughes, Hayden, Luchsinger) MIND Study Target enrollment 2,500 MESA participants across all 6 sites: Repeated cognitive testing (CASI + UDS v3) and brain MRI Adjudication of cognitive impairment A -PET imaging sub-set of 1,000 (WFU, JHU, Columbia) Centers Centers Wake Forest Johns Hopkins Columbia Minnesota Northwestern UCLA Recruitment Priority Recruitment Priority 1) Afib MRI 2) Willing in-person Memory Cog PETCog MRI MRI Exam 5 Exam 6 MIND A MIND B 2010 2012 2014 2016 2018 2020 2022 2024 4
Module B Informant Module C Cog results Module D MRI Module E PET Module A Afib 72% Yes 19% WFU 85% COL 78% JHU 89% 657 (99%) 96% 94% Consent Module B Informant Interview Module A Clinic Visit Module C Cognitive Testing Sites 58 48 95 130 156 67 554 WFU COL JHU UMN NWU UCLA TOTAL 59 132 101 139 154 72 657 58 128 101 139 155 71 652 Completion Report
Proxy / Informants Informant Spouse, partner, or companion Child Sibling Other relative Friend/neighbor Paid caregiver n % 317 169 51 36 64 48% 26% 8% 6% 10% 1% 3
Before COVID Era Anno COVIDI
Effective strategies obtain visit data Minimize participant contact and burden Data fidelity between assessments MESA MIND Planning in the COVID era
July 2019- Dec 2019 Jan 2020- June 2020 Jan 2022- June 2022 July 2018- Dec 2018 Jan 2019- June 2019 July 2020- Dec 2020 Jan 2021- June 2021 July 2021- Dec 202 July 2022- Dec 2022 Jan 2023- June 2023 Grant Funding Period 1 2 3 4 5 Visit A and B Visit A Visit B AFib MRIs all sites Protocol development / IRB approval sites Site initiation / training Visit A - Clinic visit, cog testing and MRI* TCog (Cog testing,medications, medical Hx) Visit B - Clinic visit, cog testing and MRI PET imaging (WFU, JHU, Columbia) Data cleaning, analysis, manuscripts Internal manuscript proposals Data set preparation and releases 1 2 Adapting MIND to COVID era Telephone Cognitive Testing
Recruitment Priorities for Restart Stages / Priority Stage 1 TCog MIND Component Module C - TCog Module B - Informant interview *Invite to Stages 2 and 3 Module D&E - MRI, PET Module A - Clinic visit, blood draw Consent Verbal Stage 2 Imaging Stage 3 Clinic Written Written
Next Steps: Planning MIND Visits in COVID era Need for well-validated virtual assessments Validation study of TCog battery (WFU ADRC), compares In-person Telephone Video Imaging remains a necessity onsite Virtual web-based visit options Cognitive Testing, Questionnaires, Neurological Examination Challenges: 50-75% of participants have internet access (FU21) Potential Solution: supply tablet with wireless connectivity
