Lifecourse Epidemiology Unit Research Focus and Scientific Programmes
Explore the research focus and scientific programmes of the MRC Lifecourse Epidemiology Unit, covering topics such as musculoskeletal disorders, obesity, diabetes, cardiovascular disease, and strategies for disease prevention across the lifespan. Understand lifecourse determinants of health, developmental processes, intervention strategies for vulnerable groups, and more.
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Presentation Transcript
MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director MRC LEU; Southampton 2013
MRC Lifecourse Epidemiology Unit 2010-2015 Research focus Mission Programmes Research focus Fetus & Infant Child Aetiology Mechanisms Intervention Programmes Adult Lifecourse epidemiology Nutrition, development, and lifelong health Work and Health Musculoskeletal ageing Scientific Mission To delineate: The environmental causes throughout the lifecourse of chronic musculoskeletal disorders obesity, type 2 diabetes and cardiovascular disease Population-based and high-risk preventive strategies against these disorders Mission
Lifecourse determinants of health and disease Young women s diet, body composition, physical activity, education and lifestyle before and during pregnancy Developmental plastic responses Epigenetic processes MECHANISMS Infant body composition & development Weight gain and catch-up growth Infant feeding and illnesses Childhood body composition and development Childhood diet, physical activity, lifestyle and education Work, lifestyle and health behaviours in adulthood Vulnerability to chronic disease in later life Retirement and ageing Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Harvey N, Cooper C BMJ 2012; 345: e4695
Lifecourse strategy for disease prevention No intervention Late intervention impactful for vulnerable groups Chronic NCD risk Adulthood Late intervention Childhood Earlier intervention improves functional capacity & responses to new challenges Mother & infant Early intervention Life course Plasticity Inadequate response to new challenges Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Hanson M , Godfrey K et al Prog Biophys Molec Biol 2011; 106: 272-280
Scientific Programmes Lifecourse determinants of bone and joint disease Sarcopenia, physical frailty and clinical care in older people Nutrition, development and lifelong health (Developing/transitioning populations) Nutrition, development and lifelong health (Developed populations) Work and Health
Scientific achievements Maternal vitamin D insufficiency and childhood bone mineral accrual Developmental origins of sarcopenia and cognitive function Maternal micronutrient status, birthweight and childhood adiposity Self-efficacy and control as determinants of food choice among young women Health beliefs, somatising tendency, physical exposures and musculoskeletal disability
