Medical Practice Improvement in Diabetic Populations - Insights and Models
Explore the reference model estimating medical practice improvements in diabetic populations by Jacob Barhak. Discover disease models, temporal medical improvements, and the reference model for disease progression. Gain insights into trends, advancements, and predictions in healthcare quality over the years.
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The Reference Model Estimates Medical Practice Improvement In Diabetic Populations Jacob Barhak Austin, Texas SpringSim 2017 April 23 26, 2017 Virginia Beach, Virginia, USA
Disease Models at a Glance Which behave better? Describe clinical phenomenon observed in past studies e.g. heart attacks, strokes, mortality, transplants Attempt to predict future disease progression Disease models apply a function to an initial cohort How to merge this knowledge? p 1 p Markov model 01 2 Dead Sick Normal Differential equation = / ( , ,...) dBP dAge f BP Age Are Hybrid functions models up to date? = = ( , , ,..., ) PSick P f Age BP Smoke Time 01 Jacob Barhak
Temporal Medical Improvement Healthcare quality improved through the years. 1. M.L. Weisfeldt, S.J. Zieman. Advances In The Prevention And Treatment Of Cardiovascular Disease. Health Affairs, 26, no.1 (2007):25-37. DOI: 10.1377/hlthaff.26.1.25 Shows improvement trend Lists procedures and drugs on a timeline since 1970 2. E.W. Gregg , Y.J. Cheng , S. Saydah , C. Cowie , S. Garfield , L. Geiss , L. Barker, Trends in death rates among U.S. adults with and without diabetes between 1997 and 2006: findings from the National Health Interview Survey. Diabetes Care. 2012 Jun;35(6):1252-7. DOI: 10.2337/dc11-1162 Quantifies improvement between NHANES cohorts Diabetic CVD death 2003 2004 vs. 1997 1998, Hazard Rate Ratio: 0.60 This work recalculates it using multiple models and data sources over several decades This 6 year coefficient was initially used Jacob Barhak
The Reference Model for Disease Progression Contains Validation Errors Model Results Clinical Trial Results MI = Myocardial Infarction CHD = Coronary Heart Disease A B Process CHD Pop 3 D C CHD Death No CHD MI Survive MI Eq EH E E E E Pop 2 Eq AD A 4 B 6 C 2 D 1 Pop 1 E F Process Stroke Pop 1 2 4 6 1 Death Pop 2 H G Survive Stroke Stroke Death 2 3 9 2 No Stroke Stroke Pop 3 Fitness Matrix Process Competing Mortality ` Other Death Alive Built from literature references and hence the name: The Reference Model Compares equation performance on multiple clinical studies using High Performance Computing Consumers report emulation for disease models Current version deals with diabetic populations Jacob Barhak
Results 2014 Raw Models BioMarker Correction Method_A1c Method_BMI Method_BP Method_Lipids Method_Smoke Method_MI Method_Stroke Method_DeathCHD Method_DeathStroke Method_TimeImprove FITNESS: LOW SCORE = GOOD FITNESS UKPDS33 Conventional UKPDS33 Intensive UKPDS33 Full ASPEN All Placebo ASPEN All Atorvastatin ASPEN Primary Placebo ASPEN Primary Atorvastatin ASPEN Secondary Placebo ASPEN Secondary Atorvastatin ASPEN Full ADVANCE Standard ADVANCE Intensive ADVANCE Asia Standard ADVANCE Asia Intensive ADVANCE EME Standard ADVANCE EME Intensive ADVANCE Eastern Europe Standard ADVANCE Eastern Europe Intensive ADVANCE Full ACCORD BP Standard Therapy ACCORD BP Intensive Therapy ACCORD BP Full KP 20-34 KP 35-50 KP 50-65 KP 65-75 KP 75+ KP Total NDR 20-34 NDR 35-50 NDR 50-65 NDR 65-75 NDR 75+ NDR Total AHEAD Control AHEAD Intervention AHEAD Full ADDITION Routine ADDITION Intensive ADDITION Full UKPDS33 Conventional Correlated UKPDS33 Intensive Correlated UKPDS33 Full Correlated ASPEN All Placebo Correlated ASPEN All Atorvastatin Correlated ASPEN Primary Placebo Correlated ASPEN Primary Atorvastatin Correlated ASPEN Secondary Placebo Correlated ASPEN Secondary Atorvastatin Correlated ASPEN Full Correlated ADVANCE Standard Correlated ADVANCE Intensive Correlated ADVANCE Asia Standard Correlated ADVANCE Asia Intensive Correlated ADVANCE EME Standard Correlated ADVANCE EME Intensive Correlated ADVANCE Eastern Europe Standard Correlated ADVANCE Eastern Europe Intensive Correlated ADVANCE Full Correlated ACCORD BP Standard Therapy Correlated ACCORD BP Intensive Therapy Correlated ACCORD BP Full Correlated KP 20-34 Correlated KP 35-50 Correlated KP 50-65 Correlated KP 65-75 Correlated KP 75+ Correlated KP Total Correlated NDR 20-34 Correlated NDR 35-50 Correlated NDR 50-65 Correlated NDR 65-75 Correlated NDR 75+ Correlated NDR Total Correlated AHEAD Control Correlated AHEAD Intervention Correlated AHEAD Full Correlated ADDITION Routine Correlated ADDITION Intensive Correlated ADDITION Full Correlated 0 0 0 0 0 1 1 1 1 0 0 0 0 0 1 2 1 1 0 0 0 0 0 1 3 1 1 0 0 0 0 0 1 4 1 1 0 0 0 0 0 1 5 1 1 0 0 0 0 0 1 6 1 1 0 0 0 0 0 1 7 1 1 0 0 0 0 0 1 8 1 1 0 0 0 0 0 2 1 1 1 0 0 0 0 0 2 2 1 1 0 0 0 0 0 2 3 1 1 0 0 0 0 0 2 4 1 1 0 0 0 0 0 2 6 1 1 0 0 0 0 0 3 1 1 1 0 0 0 0 0 3 2 1 1 0 0 0 0 0 3 3 1 1 0 0 0 0 0 3 4 1 1 0 0 0 0 0 3 5 1 1 0 0 0 0 0 3 7 1 1 0 0 0 0 0 3 8 1 1 0 0 0 0 0 4 1 1 1 0 0 0 0 0 4 2 1 1 0 0 0 0 0 4 3 1 1 0 0 0 0 0 4 4 1 1 0 0 0 0 0 4 5 1 1 0 0 0 0 0 4 6 1 1 0 0 0 0 0 4 7 1 1 0 0 0 0 0 4 8 1 1 0 0 0 0 0 5 1 1 1 0 0 0 0 0 5 3 1 1 0 0 0 0 0 5 4 1 1 0 0 0 0 0 5 5 1 1 0 0 0 0 0 5 6 1 1 0 0 0 0 0 6 1 1 1 0 0 0 0 0 6 2 1 1 0 0 0 0 0 6 4 1 1 0 0 0 0 0 6 5 1 1 0 0 0 0 0 6 6 1 1 0 0 0 0 0 6 7 1 1 0 0 0 0 0 6 8 1 1 0 0 0 0 0 7 1 1 1 0 0 0 0 0 7 3 1 1 0 0 0 0 0 7 4 1 1 0 0 0 0 0 7 6 1 1 0 0 0 0 0 7 7 1 1 0 0 0 0 0 8 1 1 1 0 0 0 0 0 8 3 1 1 0 0 0 0 0 8 4 1 1 0 0 0 0 0 8 6 1 1 0 0 0 0 0 8 8 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 7 1 1 1 1 1 1 1 1 8 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 4 1 1 1 1 1 1 1 2 6 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 3 2 1 1 1 1 1 1 1 3 3 1 1 1 1 1 1 1 3 4 1 1 1 1 1 1 1 3 5 1 1 1 1 1 1 1 3 7 1 1 1 1 1 1 1 3 8 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 4 2 1 1 1 1 1 1 1 4 3 1 1 1 1 1 1 1 4 4 1 1 1 1 1 1 1 4 5 1 1 1 1 1 1 1 4 6 1 1 1 1 1 1 1 4 7 1 1 1 1 1 1 1 4 8 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 5 3 1 1 1 1 1 1 1 5 4 1 1 1 1 1 1 1 5 5 1 1 1 1 1 1 1 5 6 1 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 6 2 1 1 1 1 1 1 1 6 4 1 1 1 1 1 1 1 6 5 1 1 1 1 1 1 1 6 6 1 1 1 1 1 1 1 6 7 1 1 1 1 1 1 1 6 8 1 1 1 1 1 1 1 7 1 1 1 1 1 1 1 1 7 3 1 1 1 1 1 1 1 7 4 1 1 1 1 1 1 1 7 6 1 1 1 1 1 1 1 7 7 1 1 1 1 1 1 1 8 1 1 1 1 1 1 1 1 8 3 1 1 1 1 1 1 1 8 4 1 1 1 1 1 1 1 8 6 1 1 1 1 1 1 1 8 8 1 1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 13.845 9.9209 13.801 18.728 18.276 28.262 25.055 36.435 20.292 15.186 47.506 64.295 66.355 53.918 62.2 86.633 44.423 63.465 37.867 39.663 38.501 48.886 9.5786 18.641 41.479 72.827 125.89 57.085 8.5147 20.159 27.464 48.969 79.257 43.058 70.932 77.084 71.284 41.803 48.036 35.644 25.045 50.133 40.928 45.875 54.923 61.437 59.552 28.469 50.693 41.375 77.644 63.604 90.327 111.28 82.684 69.03 85.726 83.908 92.386 74.296 82.016 78.132 23.184 51.877 77.822 123.21 166.68 146.38 26.249 32.83 49.132 97.757 89.257 95.503 81.756 58.952 63.695 59.802 66.5 62.438 20.743 11.567 17.379 14.958 25.426 21.829 19.761 21.628 24.845 6.4129 57.988 49.845 58.244 58.964 56.706 69.307 46.964 54.345 49.677 52.236 43.179 43.179 6.2249 25.283 56.323 75.849 119.96 58.401 9.2195 11.67 25.24 54.641 69.089 33.218 69.883 62.48 74.857 48.485 46.707 45.747 35.017 44.224 34.87 49.066 56.42 51.405 65.198 33.422 43.592 51.508 70.806 77.39 88.441 81.794 93.358 102.48 90.926 77.843 85.034 71.869 73.423 75.553 18.344 52.607 82.506 108.21 149.46 134.33 20.591 35.037 56.155 81.827 105.56 86.129 72.35 61.126 66.499 56.732 72.244 61.076 15.914 8.9666 20.605 19.71 23.717 13.379 31.619 18.987 24.89 10.302 55.213 76.751 41.785 63.998 57.29 70.818 52.09 46.219 44.613 62.209 54.278 57.444 16.21 22.147 59.064 79.961 120.64 54.534 10.124 14.327 32.149 49.87 48.495 35.984 64.859 66.244 73.654 61.486 44.931 58.691 29.24 50.879 47.177 43.041 51.344 62.121 59.044 25.348 47.085 34.44 77.936 65.727 95.526 83.132 82.888 78.579 79.317 91.647 103.18 65.973 86.957 79.028 26.8 50.185 89.987 121.29 142.69 145.46 20.616 34.692 44.513 94.204 98.317 88.986 70.084 70.534 73.498 61.561 58.596 66.082 21.72 7.3778 13.518 6.8007 19.033 23.351 25.065 18.392 22.444 12.966 54.352 62.371 43.722 56.296 65.003 70.419 56.764 59.095 51.244 44.658 43.943 53.715 12.43 18.661 50.085 90.978 152.26 69.42 12.59 15.871 39.106 52.465 66.785 57.078 60.769 70.609 75.615 50.205 53.645 59.592 31.782 45.578 43.355 39.869 50.51 55.944 66.144 35.263 51.227 38.028 69.963 71.557 107.34 98.4 64.034 86.909 82.884 85.872 75.538 63.429 73.702 88.19 16.837 51.834 82.272 115.23 173.54 129.98 19.723 25.059 56.598 96.889 97.194 97.033 76.008 66.24 78.252 69.423 63.951 63.124 25.441 22.481 21.071 19.742 41.707 17.168 27.051 21.407 16.023 14.427 64.557 57.927 68.608 68.148 76.042 69.997 60.727 65.839 56.625 46.8 57.022 54.137 11.091 22.011 64.37 81.59 136.99 78.841 13.892 9.5373 39.603 60.983 57.625 43.44 83.678 73.371 76.566 63.02 53.607 59.096 41.778 43.554 56.058 50.351 63.101 60.519 63.902 46.583 45.615 38.391 68.62 85.706 98.072 92.52 115.41 92.864 91.539 95.874 95.827 80.292 73.788 91.855 20.694 61.229 100.3 124.15 165.56 123.38 20.616 30.708 48.87 100.33 97.367 101.03 80.386 74.949 64.832 66.779 57.4 58.788 25.36 16.845 15.365 15.033 30.533 21.477 30.927 32.384 20.421 13.053 51.108 60.38 63.073 54.858 83.53 68.257 53.192 65.746 43.77 64.068 53.488 55.247 10.416 28.452 51.337 108.21 138.95 73.695 11.068 11.002 36.312 59.206 73.422 42.686 72.747 96.76 82.247 51.24 49.772 46.046 38.2 50.664 45.647 51.875 58.801 64.85 61.029 42.991 55.286 56.878 79.464 79.682 84.478 90.082 91.899 91.993 98.558 91.337 87.727 89.338 90.6 90.717 20.899 46.43 97.341 121.38 167.94 137.77 23.505 32.168 63.415 91.862 95.735 105.78 76.181 83.084 78.205 72.317 74.113 73.898 28.089 13.75 15.861 8.544 24.515 15.969 25.788 16.332 19.261 8.8388 59.33 56.294 53.692 52.148 55.415 70.061 40.447 48.757 42.639 45.7 56.192 51.351 8.6891 26.405 47.718 80.425 110.35 60.805 10.817 16.474 36.675 54.176 64.07 41.011 58.605 71.308 73.587 53.505 56.013 52.037 29.777 46.206 49.234 46.511 49.825 56.085 65.843 24.031 49.684 48.085 73.629 90.396 89.293 96.726 85.303 88.88 88.135 79.791 88.481 70.57 81.732 71.135 19.164 43.669 90.497 116.15 144.18 137.69 16.688 34.411 51.533 87.888 113.48 89.436 66.125 77.431 74.073 63.663 71.174 72.863 18.589 20.252 22.986 17.059 25.03 23.452 27.249 25.402 20.261 18.224 57.614 62.628 47.367 73.71 66.351 94.739 61.91 65.786 72.98 58.773 52.165 49.873 10.782 24.213 59.405 87.172 107.62 75.375 14.089 6.8789 43.955 61.995 65.018 43.592 79.179 86.411 82.891 57.151 60.254 60.706 46.879 45.002 53.315 49.792 60.733 60.92 57.528 38.542 46.266 46.461 79.925 84.923 96.987 95.211 96.922 95.439 87.519 91.411 103.43 87.007 86.871 80.905 22.428 56.866 103.5 135.03 143.89 144.67 28.302 32.224 54.05 92.127 105.36 109.22 68.316 73.875 87.681 69.762 61.129 70.285 14.877 21.469 30.024 25.169 23.606 24.723 28.723 22.738 18.358 16.458 33.671 23.299 23.829 27.961 55.4 79.637 54.659 55.998 56.567 41.106 44.685 39.712 20.577 5.9306 21.303 16.271 30.004 22.023 18.561 19.856 15.508 12.384 51.022 41.756 21.312 36.105 76.085 66.756 61.926 24.352 45.178 41.27 36.752 32.433 11.158 29.24 59.435 91.699 130.45 66.652 10.607 26.202 22.874 45.731 32.814 57.335 79.018 75.02 83.698 52.242 51.032 58.102 18.466 19.134 13.371 32.829 33.845 35.809 32.411 19.912 14.15 18.021 21.534 23.617 21.989 34.673 20.676 22.858 12.227 22.575 40.267 40.859 30.695 35.688 77.162 56.189 49.342 39.704 46.879 49.68 35.563 51.586 9.2601 27.143 45.632 83.561 126.73 71.69 19.455 21.13 34.109 50.73 44.617 43.142 87.756 79.306 72.813 53.35 51.218 47.682 16.524 20.554 12.21 30.008 45.686 43.442 34.154 26.94 27.299 23.693 33.698 42.036 35.864 33.326 62.14 57.002 42.055 50.776 50.105 52.059 72.398 72.621 13.519 34.921 62.552 93.714 133.28 95.51 19.609 27.166 52.902 65.503 53.406 48.489 75.585 51.151 70.443 52.19 60.289 49.258 22.322 8.3755 14.49 19.767 24.094 17.93 24.31 28.539 12.669 9.3608 29.328 40.1 26.298 17.407 58.554 61.563 41.711 50.381 49.65 41.207 49.113 46.156 12.99 32.07 51.442 100.96 170.14 75.757 14.714 19.285 37.39 59.507 64.086 38.225 72.878 77.785 79.59 54.615 43.076 53.356 15.451 20.723 17.386 32.098 28.853 36.038 39.392 25.583 31.627 16.819 22.69 45.233 37.924 32.833 50.886 63.691 52.347 57.039 59.896 45.972 44.083 51.74 9.7211 38.383 62.231 107.39 170.43 90.373 15.89 23.02 42.933 61.096 56.063 54.319 78.043 73.768 73.294 47.183 47.286 59.934 26.799 13.62 21.363 22.55 25.758 24.026 30.471 28.465 27.595 16.602 48.277 50.396 15.862 33.193 64.067 77.227 67.692 60.414 66.593 59.746 67.268 61.969 12.835 27.152 54.014 114.25 143.28 73.092 11.853 18.698 48.659 53.613 58.731 51.922 81.876 91.082 84.991 57.232 49.216 54.088 21.38 21.678 29.491 36.708 40.401 39.601 39.592 34.857 42.924 29.94 43.854 48.48 33.974 35.592 63.114 72.985 61.465 77.057 73.478 69.432 65.846 67.539 13.086 34.486 81.383 117.32 145.94 104.39 18.788 32.516 55.431 51.495 46.198 65.187 84.94 87.17 85.083 54.208 61.096 69.784 29.021 25.523 26.102 19.352 25.681 21.136 18.069 21.645 34.18 17.281 41.595 41.158 37.481 40.272 57.46 57.682 42.207 28.723 46.829 54.324 46.258 55.743 11.158 24.088 46.489 87.918 154.28 64.721 8.6023 7.3993 29.336 39.775 77.955 28.286 76.02 71.852 84.123 36.949 36.817 38.045 15.477 9.5029 9.9451 37.128 29.762 37.871 26.669 35.567 51.098 26.441 50.704 46.912 68.468 50.06 70.355 72.191 51.43 59.377 77.104 58.729 60.977 71.765 15.636 26.182 52.49 115.03 177.97 110.59 32.342 13.279 15.306 20.791 20.827 18.574 18.049 11.247 24.91 7.673 43.5 42.017 38.168 36.412 56.127 50.933 39.189 42.071 50.379 50.431 45.203 63.368 14.44 22.793 42.65 92.058 142.26 72.795 13.21 9.8939 38.989 46.802 73.614 37.019 74.346 77.128 90.289 38.949 45.708 27.214 20.774 18.384 11.932 26.225 37.699 37.888 27.102 29.279 33.151 21.474 38.628 54.141 54.054 54.107 67.155 72.523 39.243 52.553 67.396 62.792 58.823 70.195 18.655 41.812 62.51 108.78 147.52 95.926 14.142 18.774 26.087 53.245 62.675 69.181 78.214 70.642 76.494 46.054 50.433 41.627 18.513 21.563 19.029 14.612 23.345 19.222 20.056 16.477 29.466 9.6631 55.843 56.967 39.24 32.23 44.933 71.574 32.367 58.689 50.004 48.797 61.914 48.76 13.647 24.729 47.568 95.082 139.66 69.085 11.511 5.8152 32.594 35.556 65.029 33.12 75.75 95.205 71.723 39.462 35.784 33.219 21.087 15.375 15.437 26.125 33.612 33.716 29.47 36.235 50.227 22.291 47.295 42.104 42.926 52.6 66.854 64.645 37.35 52.169 59.363 71.287 71.794 66.14 17.664 39.045 71.084 116.12 163.05 108.9 15.508 19.142 29.252 49.883 63.041 69.283 99.269 83.709 71.775 32.791 51.909 40.186 28.939 16.842 28.894 11.214 19.824 17.678 28.557 25.564 45.044 9.1173 38.253 44.878 32.462 56.921 47.274 65.24 36.219 54.452 42.919 51.67 54.686 47.809 15.827 22.344 66.972 96.446 176.27 73.101 12.349 12.333 22.042 49.885 59.828 39.395 93.065 83.222 79.82 28.836 36.8 31.026 21.206 14.287 11.776 23.89 43.766 33.856 36.349 29.095 48.997 24.246 36.768 45.645 48.931 64.946 41.26 74.309 36.924 39.558 63.477 64.566 55.967 70.295 12.787 29.176 55.794 123.64 190.05 82.699 18.868 18.374 35.796 61.754 73.911 51.839 75.834 94.905 89.498 53.033 64.323 55.826 28.647 25.693 34.46 21.777 28.64 22.051 19.526 22.433 36.159 21.439 52.773 59.781 37.374 56.91 62.849 76.003 57.99 66.866 53.893 59.437 58.258 61.252 11.822 26.641 53.81 96.781 158.43 75.673 10.512 4.9747 37.859 47.098 72.571 45.236 94.463 100.32 94.327 41.743 50.926 47.646 44.867 29.95 28.657 32.133 36.756 35.539 38.558 38.856 49.412 23.835 42.697 47.722 53.896 51.297 67.325 84.092 46.161 68.145 79.917 75.406 57.887 79.638 15.058 36.763 78.789 121.52 150.45 112.81 13.342 23.746 41.891 52.651 60.096 61.239 93.595 73.355 91.93 52.598 63.646 61.428 34.265 29.859 29.271 23.071 20.821 18.534 26.201 15.564 26.472 18.698 46.383 42.509 31.912 43.188 49.771 54.975 27.041 45.943 56.067 59.228 42.979 56.582 13.666 26.125 47.233 100.15 156.34 68.943 17.335 10.147 31.492 36.201 54.051 40.763 78.257 82.891 72.427 42.997 55.709 33.916 25.113 16.176 17.635 28.592 33.478 47.122 27.884 35.093 47.069 22.943 50.438 43.599 37.17 57.976 68.5 62.887 55.163 60.985 74.954 55.046 75.698 68.845 18.875 25.933 50.087 111.64 134.78 96.354 20.616 18.66 49.204 56.219 72.99 56.097 72.16 76.636 69.06 41.104 52.309 57.607 42.527 27.102 28.788 20.463 18.255 25.952 21.886 23.617 32.427 16.051 55.319 47.038 39.136 41.4 71.311 75.693 55.986 41.002 58.076 67.685 63.509 65.174 9.7211 23.335 54.268 109.53 171.77 67.68 12.083 11.469 36.663 55.371 69.506 48.533 93.743 97.524 85.081 47.297 56.646 44.67 36.785 31.852 30.162 28.539 39.099 38.643 47.077 28.531 48.278 39.867 42.942 56.497 62.159 53.256 74.154 91.62 53.006 60.559 71.59 71.671 68.857 84.386 18.398 35.795 81.783 130.41 180.34 120.08 16.14 20.272 44.256 68.839 75.673 71.476 90.902 82.665 90.223 58.6 62.646 61.314 19.646 48.374 28.99 34.627 27.263 35.071 36.946 21.389 25.164 23.883 69.632 54.492 63.567 61.33 72.746 76.438 62.346 63.422 70.32 55.698 59.398 55.413 14.569 42.039 68.536 94.939 109.8 67.982 20.518 37.78 69.625 51.793 35.259 54.574 88.669 102.34 102.45 92.903 81.532 94.656 67.057 66.06 74.527 52.436 41.842 58.764 64.393 30.631 40.945 43.438 63.241 73.958 64.347 77.527 80.082 95.572 66.863 85.61 76.548 73.541 79.073 66.329 13.435 54.461 94.888 120.34 122.6 120.86 26.315 43.572 63.994 65.514 75.694 87.564 87.741 95.503 82.365 79.205 78.653 83.183 24.438 53.194 39.663 18.412 32.152 32.734 30.615 17.464 17.132 19.586 56.87 50.357 70.606 69.482 73.207 72.378 63.203 47.168 79.124 52.765 48.095 54.565 25.212 46.236 24.09 16.748 28.134 40.109 24.885 18.748 25.676 13.505 70.452 52.811 60.198 61.8 80.652 84.907 44.123 64.786 70.971 60.915 53.454 55.061 22.226 38.714 82.526 87.079 89.489 81.102 20.591 37.389 51.273 36.96 27.274 52.222 89.627 88.294 108.63 79.546 93.404 77.888 65.243 78.917 72.065 48.772 52.628 49.401 43.494 40.826 30.895 42.108 58.559 77.746 84.239 50.418 90.437 105.72 59.738 52.494 71.564 66.991 71.029 74.43 22.55 67.017 104.78 92.933 100.17 113.36 37.443 48.992 62.784 62.425 25.634 70.972 92.186 94.075 71.927 99.736 92.519 90.64 32.941 49.011 43.844 20.803 29.175 43.378 36.598 27.523 44.931 26.429 48.047 20.39 28.718 19.548 67.419 62.457 50.569 71.103 100.8 96.653 71.663 83.41 71.669 51.831 71.858 75.485 14.824 41.161 84.364 92.349 101.63 69.721 27.613 35.593 61.333 60.983 31.874 56.767 108.45 110.65 115.52 79.955 94.11 102.93 66.818 79.939 69.203 43.94 54.884 59.864 55.675 28.588 32.265 41.933 60.522 76.085 81.799 78.483 103.6 83.046 81.632 82.071 87.115 91.187 77.79 77.927 12.52 66.708 103.03 103.4 115.63 98.165 20.797 44.627 66.774 70.156 27.407 69.33 102.19 112.24 116.44 87.483 99.746 86.522 23.545 30.947 49.925 15.898 38.22 37.928 35.054 31.788 36.565 24.599 60.455 56.731 72.643 68.833 76.202 85.255 57.616 60.065 75.489 63.254 58.294 67.907 16.34 49.952 90.579 109.08 133.03 77.445 15.264 32.871 63.057 61.341 24.817 53.111 102.07 108.44 132.97 85.905 93.136 88.553 62.605 76.491 67.86 43.414 52.17 66.996 55.168 28.697 45.853 51.138 72.597 81.242 86.272 91.78 82.158 82.689 65.933 80.011 96.398 94.901 86.883 82.63 25.353 67.22 106.32 125.86 125.13 120.49 22.902 45.628 71.383 76.29 42.953 72.603 104.02 107.19 106.63 95.514 91.88 87.719 23.493 39.597 45.689 19.812 33.534 37.37 40.611 15.867 21.296 24.731 46.695 62.054 59.149 58.164 79.755 84.976 48.475 73.547 66.505 66.038 48.656 42.005 12.47 34.081 74.751 75.791 100.44 66.857 20.591 35.301 55.483 60.307 18.766 47.645 106.46 106.19 97.908 72.744 80.737 95.466 63.007 68.262 66.368 47.721 50.826 63.847 54.21 14.95 39.994 46.703 75.548 66.837 89.868 60.594 83.518 94.421 66.597 68.558 79.019 59.389 66.565 78.441 17.248 57.953 96.339 94.177 95.292 95.3 22.192 47.019 62.256 59.036 33.633 73.35 72.506 83.364 92.64 95.914 100.69 91.152 37.46 45.211 43.035 25.947 33.756 33.604 34.623 26.944 25.632 18.183 62.493 63.265 65.328 59.716 87.843 107.04 65.838 80.207 73.266 67.187 62.344 69.109 12.58 36.589 78.202 98.871 106.52 79.507 14.916 42.487 57.363 45.059 25.763 60.571 106.01 93.998 107.75 90.608 98.395 100.96 75.907 78.752 69.77 49.115 44.054 57.955 59.163 25.189 42.03 49.073 63.765 92.794 84.779 84.704 97.182 99.477 89.076 78.427 84.847 89.569 70.092 87.763 15.78 54.587 104.47 111.56 121.68 120.91 26.618 47.68 82.755 81.428 46.493 69.587 106.43 90.164 94.813 79.481 101.51 90.395 30.928 22.309 25.162 11.336 16.225 19.602 27.937 39.291 14.37 13.233 32.628 24.991 18.363 15.199 46.02 50.709 14.142 26.9 37.587 36.625 31.294 36.565 8.7034 25.303 42.314 67.829 122.97 52.126 19.092 17.285 25.144 25.149 50.641 37.408 56.887 55.146 55.549 27.622 36.79 35.565 20.076 15.176 17.591 27.78 16.263 29.891 26.41 30.042 30.212 16.534 24.08 48.14 33.719 25.597 47.588 42.596 34.788 39.764 52.458 47.55 37.939 49.177 9.6047 30.802 51.505 69.471 143.68 85.889 15.62 25.086 29.899 40.725 74.145 54.091 54.997 58.09 46.329 32.749 35.868 40.157 35.489 22.092 22.559 13.5 20.18 16.568 20.255 30.307 17.4 13.091 14.687 20.973 11.082 19.391 41.9 43.327 11.705 16.697 19.2 41.478 35.084 33.807 9.2601 27.848 32.646 59.002 117.85 56.335 15.652 16.095 26.859 31.541 25.623 28.898 53.129 42.788 55.445 33.053 41.527 40.019 19.36 10.647 19.098 15.969 24.845 25.328 18.432 28.022 21.249 8.8388 14.243 21.125 12.704 22.93 34.598 51.231 21.772 29.329 52.832 52.113 38.5 43.947 14.133 41.623 50.671 81.017 121.36 76.413 18.358 21.73 33.561 41.857 29.897 31.001 60.962 62.159 51.32 32.307 47.17 41.368 26.746 28.781 26.797 11.853 10.025 15.256 18.514 30.042 12.99 5.534 18.902 31.129 11.645 11.305 27.528 42.956 18.778 28.046 28.699 40.649 39.695 35.651 13.332 25.357 41.225 84.27 153.37 59.948 10.512 22.385 43.823 24.332 33.76 18.092 53.061 62.615 70.58 38.965 46.704 38.522 22.985 14.293 13.712 22.254 20.676 23.043 30.467 23.638 16.636 13.005 24.375 23.549 7.5631 18.963 43.499 49.002 20.616 53.584 51.301 45.006 44.563 43.518 15.748 24.865 52.564 78.054 146.51 73.454 20.125 21.946 24.373 28.16 30.776 46.425 56.477 57.314 65.214 50.312 41.632 41.58 31.944 24.337 28.137 10.794 17.769 22.187 18.419 28.883 21.731 16.617 32.344 34.507 9.757 12.239 60.544 59.516 43.442 49.394 42.094 50.946 38.368 45.268 14.448 22.31 47.755 84.898 120.47 61.502 20.809 15.477 26.408 38.787 18.296 24.592 58.073 51.57 62.043 46.556 48.14 53.161 35.261 31.278 32.085 20.094 30.781 29.783 25.734 36.187 27.762 20.673 27.594 25.876 19.975 17.539 53.303 58.677 39.138 33.124 57.675 48.552 61.575 56.657 14.204 32.5 64.659 78.838 135.01 80.119 19.416 24.145 45.235 51.342 32.098 42.217 70.616 54.887 65.876 50.985 46.371 53.864 44.571 32.361 33.903 12.942 21.817 18.828 19.634 38.347 32.5 17.752 20.736 22.447 24.008 16.118 56.793 65.109 51.728 48.726 40.842 57.773 44.263 58.277 12.42 25.52 46.179 90.069 126.57 70.301 10.63 17.474 28.946 36.397 23.97 32.091 53.141 65.672 73.802 49.409 38.775 42.855 29.451 24.575 18.859 21.296 31.165 29.753 28.408 34.954 40.231 23.203 30.496 30.896 25.04 36.058 54.56 42.433 40.494 47.445 46.133 66.139 64.641 72.515 11.811 38.594 72.232 84.592 137.55 100.39 28.018 26.907 34.039 38.803 52.656 41.651 59.041 65.073 75.584 38.92 63.775 51.141 37.471 33.461 35.026 8.6603 16.47 16.132 15.867 20.218 14.124 14.921 17.259 34.178 19.89 37.561 33.592 50.752 11.933 29.117 32.119 45.713 35.475 37.577 12.52 21.101 28.346 58.004 131.61 49.907 12.903 10.91 19.791 28.799 69.796 19.857 79.005 57.577 55.767 26.462 29.043 20.733 32.363 15.16 23.076 30.749 20.457 23.569 24.187 26.387 45.158 23.305 31.834 35.325 21.886 42.818 44.993 43.25 37.855 26.495 52.974 55.164 54.034 46.496 14.195 29.39 45.346 85.894 155.19 93.187 44.368 35.164 36.421 9.9121 16.837 11.958 15.289 21.737 6.9821 14.392 34.469 12.101 19.606 23.622 41.068 40.8 16.535 34.044 35.576 45.214 45.243 38.037 11.068 33.023 38.292 65.856 129.12 51.387 11.853 8.5583 23.185 21.356 34.202 16.759 60.02 58.031 63.702 31.949 26.977 35.936 27.763 19.314 29.512 14.739 16.47 21.249 24.723 20.081 14.534 16.458 19.712 25.324 40.085 33.199 44.497 37.963 18.968 22.082 36.36 42.295 40.244 47.307 15.922 28.745 58.922 69.266 136.99 84.6 19.723 15.146 25.075 24.187 42.142 42.424 67.676 67.292 69.013 44.682 32.879 47.293 38.836 30.958 34.474 11.478 18.987 11.64 14.95 20.609 20.555 5.2321 21.709 25.671 30.338 48.079 47.487 25.179 17.983 18.493 43.092 47.461 41.116 41.21 12.669 21.018 34.565 81.655 156.63 68.454 14.577 20.782 24.528 25.447 34.752 19.705 61.866 63.883 72.162 26.472 21.201 21.304 29.438 20.303 18.335 15.66 18.187 21.61 28.736 18.615 35.341 11.264 35.163 43.994 40.482 40.603 36.97 45.609 24.429 38.275 45.514 51.129 43.529 53.258 17.226 28.125 51.578 87.049 149.19 89.358 16.155 19.024 24.432 38.325 42.117 39.601 72.353 70.301 73.762 26.206 31.93 37.9 39.246 33.267 36.6 17.734 19.429 21.207 20.457 17.464 23.2 9.5851 41.6 47.933 37.899 29.412 32.841 11.895 15.141 18.628 12.39 29.125 24.094 19.439 36.251 41.725 38.314 27.419 57.815 56.512 30.189 35.93 45.278 56.187 53.884 64.119 10.954 17.059 46.193 93.113 139.23 58.079 48.124 30.243 36.58 8.2614 15.74 14.891 13.124 19.416 13.509 8.3141 25.422 20.73 29.234 19.657 49.169 43.69 30.659 40.696 42.62 47.86 33.434 53.349 14.62 27.477 46.749 73.469 111.68 58.963 16.155 17.862 30.132 24.22 29.886 19.287 56.247 45.382 74.76 29.034 35.627 28.013 27.943 22.94 21.559 10.428 27.409 24.95 18.131 17.958 19.685 18.162 29.326 43.533 24.339 38.846 51.164 48.943 31.818 29.003 44.287 47.601 40.044 53.518 16.681 49.852 60.908 91.801 127.52 70.382 14.983 19.715 25.847 37.036 43.524 38.335 60.117 65.151 58.458 30.492 36.623 40.141 42.4 8.7074 14.004 12.334 17.958 26.707 34.471 25.323 26.725 24.955 15.285 41.407 40.485 25.152 31.768 77.226 75.986 55.391 55.688 54.271 53.129 43.848 41.723 7.5993 20.579 54.429 74.128 139.45 67.038 9.9247 13.674 38.092 49.679 57.044 52.783 76.79 67.866 76.631 52.398 59.205 46.064 15.251 16.231 20.25 35.69 49.267 32.415 46.144 34.007 34.713 47.206 49.93 42.482 32.444 36.775 70.437 75.125 71.28 72.886 61.125 52.944 56.97 62.042 8.6168 35.857 54.208 110.65 163.58 95.882 19.105 37.803 47.011 64.226 100.94 69.085 80.562 64.256 70.438 54.658 55.206 58.921 19.295 18.4 10.827 19.666 24.804 23.318 22.045 20.603 19.384 14.366 33.528 38.502 26.833 42.112 69.275 71.681 52.492 54.834 60.871 46.29 56.944 40.63 11.214 34.081 48.629 90.264 148.37 52.455 13.946 13.674 51.033 55.291 57.662 32.555 77.66 70.503 85.119 51.786 50.274 48.261 10.461 25.284 17.776 39.538 39.793 37.875 31.867 17.882 27.861 32.317 42.844 44.373 23.524 34.17 59.968 60.731 47.802 63.178 59.341 61.302 56.945 75.191 14.722 39.781 76.776 107.35 137.73 105.33 20.261 24.453 47.772 60.446 70.096 76.313 81.705 66.106 79.521 58.185 63.457 70.159 22.161 5.882 10.081 20.408 23.329 23.377 23.728 22.282 26.847 13.346 32.118 46.222 16.565 33.091 54.938 70.566 51.763 44.089 51.511 47.197 35.498 48.983 12.43 30.85 44.623 88.935 149.09 73.321 12.083 16.805 40.286 58.956 63.179 40.46 76.686 81.605 99.892 42.793 60.287 54.968 17.164 19.582 20.994 34.893 32.226 36.177 35.85 22.655 25.01 21.246 30.09 39.301 31.837 35.066 74.359 64.365 45.957 67.574 53.307 57.254 48.933 56.039 12.894 37.616 58.792 114.93 164.35 99.61 23.717 25.823 45.387 66.345 69.087 62.325 79.503 80.082 84.291 69.432 65.297 59.636 15.355 15.535 15.849 27.618 27.322 25.48 37.977 29.908 29.026 15.012 47.371 53.195 26.42 37.515 76.341 89.269 67.738 65.854 56.636 60.286 58.071 68.612 10.886 25.005 64.861 115.47 160.29 70.269 9.6177 20.987 51.688 42.152 64.086 50.881 79.947 97.552 82.779 61.247 77.685 60.867 27.631 24.58 30.877 31.725 37.36 55.195 39.972 30.733 43.362 33.588 56.008 47.233 47.94 45.991 55.007 71.372 56.187 59.193 82.989 61.572 78.007 71.1 11.937 41.373 73.372 111.63 166.42 115.72 13.49 11.593 15.338 22.028 24.31 30.976 31.405 17.241 23.011 25.615 51.608 45.006 20.577 30.496 67.543 71.602 61.995 65.408 55.428 51.965 37.212 49.145 9.8362 25.593 53.061 90.678 131.96 79.325 16.447 23.512 47.14 51.05 77.834 54.017 77.866 61.673 80.587 56.582 58.425 48.195 20.637 21.928 29.345 29.202 28.909 41.94 35.843 18.848 24.3 27.652 39.826 45.125 24.323 25.231 63.307 67.655 53.213 62.605 50.416 57.425 51.509 66.613 13.638 42.656 60.758 92.915 163.6 94.927 22.192 33.749 58.791 63.168 68.254 64.919 66.616 63.892 75.666 66.549 63.963 72.464 21.597 13.378 22.875 16.583 15.322 15.508 17.428 31.678 16.263 14.031 21.223 31.085 8.3785 7.7846 54.329 49.808 29.333 25.448 28.454 41.016 31.657 36.79 8.6891 20.555 46.163 67.088 124.41 59.195 19.144 14.446 22.984 32.35 62.73 34.612 52.557 61.048 59.625 38.125 39.303 40.934 10.782 7.4727 9.1406 23.157 24.109 29.749 31.504 37.706 27.641 17.688 30.04 38.665 16.625 14.22 56.379 47.64 43.021 41.792 41.539 48.724 56.919 56.203 7.7782 29.373 52.086 63.411 140.78 69.716 19.105 33.713 29.586 50.906 72.896 38.87 60.916 66.304 54.594 42.512 52.043 40.072 27.906 19.551 20.415 15.851 17.168 18.615 19.786 31.643 21.628 10.398 14.852 22.662 9.9599 15.434 53.907 62.044 30.223 35.457 30.927 39.679 41.148 42.953 11.5 26.851 49.028 71.99 106.28 50.997 18.028 27.487 24.69 42.691 45.997 40.938 53.307 58.164 59.196 45.667 46.027 53.757 12.93 8.1061 16.278 15.223 25.705 33.738 22.616 25.894 21.272 21.051 26.433 28.621 11.278 10.139 31.016 45.701 27.434 30.345 34.112 44.751 45.345 55.179 14.265 33.027 46.637 80.785 119.64 72.526 16.808 21.101 34.39 39.095 40.065 53.196 63.019 60.015 53.211 44.396 44.73 50.53 28.312 16.665 27.372 9.0277 21.196 22.544 17.578 24.031 14.23 6.093 26.189 26.899 13.993 11.305 36.434 50.214 24.633 18.601 14.214 39.189 32.422 40.149 13.802 23.103 43.903 82.623 139.15 64.484 32.555 23.987 35.901 13.647 21.668 21.937 19.039 27.785 28.262 7.5416 24.951 38.892 13.327 23.264 62.698 68.724 42.176 48.734 41.208 57.188 55.309 55.794 12.369 23.13 44.866 73.012 133.82 62.938 14.318 20.83 35.596 39.677 41.185 35.738 72.402 70.921 69.774 43.491 52.835 52.941 21.007 19.346 25.631 30.891 32.346 32.585 20.652 39.449 43.099 21.694 29.311 30.982 13.491 28.865 47.074 50.874 38.887 47.493 43.143 58.925 64.442 62.037 13.847 41.788 73.14 104.73 150.6 89.081 27.722 30.987 32.74 44.129 45.768 51.31 58.915 68.5 65.599 54.53 44.925 43.442 36.855 23.567 30.882 17.479 18.426 24.688 30.765 33.249 21.703 12.821 41.778 34.084 12.681 15.792 67.073 65.529 36.761 62.645 50.778 44.842 42.579 44.361 10.332 28.062 46.837 82.175 121.07 64.22 14.983 26.651 45.816 44.184 41.158 23.592 62.851 66.385 71.871 47.26 55.322 50.793 37.987 29.784 33.47 33.365 30.025 34.446 37.845 30.042 32.488 23.476 43.963 37.388 5.8652 27.637 47.745 56.838 34.658 36.829 49.611 55.671 53.258 53.093 11.99 36.844 60.087 96.893 139.4 93.513 25.06 27.341 37.43 53.151 31.26 49.373 62.877 64.942 75.112 49.855 66.577 69.144 18.076 11.089 19.788 15.443 15.732 24.97 13.36 23.796 21.178 9.9058 29.554 35.333 38.701 42.546 57.651 48.293 35.808 20.533 27.264 43.846 34.195 39.127 9.9373 17.84 50.779 68.982 125.93 59.028 12.104 11.015 44.183 48.403 53.201 41.281 47.012 53.284 62.661 17.27 24.088 26.683 27.212 44.587 33.331 55.489 48.515 70.742 39.437 37.343 37.878 37.012 48.465 66.911 56.461 63.74 81.358 56.241 61.221 59.291 68.712 63.237 69.006 75.971 14.414 46.508 70.523 120.6 169.44 115.28 17.029 26.466 61.874 88.339 103.42 95.831 50.377 56.68 53.693 37.128 43.629 18.592 16.406 6.6215 18.288 14.916 16.078 23.817 16.666 21.29 7.9057 14.659 38.68 35.543 31.645 42.995 56.84 53.17 55.611 26.161 42.821 42.803 35.936 41.785 12.61 28.377 49.015 78.278 109.5 58.718 15.443 19.024 36.312 51.624 64.771 40.288 48.351 58.972 69.248 27.308 31.918 27.648 37.122 49.312 47.137 46.06 41.806 57.708 39.922 28.275 38.856 43.109 51.275 52.564 65.646 56.53 56.879 65.08 44.75 44.562 68.408 68.045 58.119 60.862 17.909 56.73 77.721 104.59 148.61 127.26 27.83 32.003 60.316 86.475 114.26 95.361 66.484 61.401 56.184 42.773 37.987 38.827 19.626 11.106 22.66 13.388 23.098 15.313 14.44 21.972 15.108 17.084 43.227 24.116 38.629 27.893 57.131 42.939 32.212 23.778 33.854 49.054 42.994 44.754 15.124 33.47 46.699 89.758 102.42 63.266 18.385 24.853 30.083 55.645 66.278 47.288 60.868 64.362 60.194 22.517 35.658 28.799 34.794 45.417 41.53 40.611 50.946 61.786 40.367 28.434 27.942 31.351 50.875 62.917 64.96 62.319 70.427 55.6 68.606 38.387 72.461 71.195 65.735 68.863 20.748 46.257 93.747 100.06 155.75 137.7 24.87 12.243 40.219 90.075 103.1 98.892 69.597 65.45 56.258 29.979 34.275 33.136 23.232 10.896 16.893 11.597 12.155 30.36 13.62 17.923 13.955 14.987 29.079 31.471 50.468 27.287 60.055 38.771 17.292 28.217 32.758 53.79 42.236 46.915 9.1241 27.897 50.381 90.768 139.18 67.215 5.1478 13.904 31.2 54.116 73.475 40.898 66.883 57.024 61.244 18.289 28.062 28.142 39.19 41.514 35.897 51.839 37.383 58.393 45.117 32.989 38.409 30.568 51.636 49.007 76.318 68.79 57.543 72.58 67.206 45.115 69.157 69.435 50.369 64.464 21.926 46.872 75.773 131.69 185.27 136.82 25.544 35.12 62.145 102.38 96.038 102.67 55.963 63.067 69.186 29.351 34.868 39.034 16.078 18.277 23.216 18.848 17.861 26.311 19.532 21.142 16.837 18.169 39.106 41.326 41.864 30.312 54.297 46.122 47.083 41.161 46.981 50.254 50.318 56.293 12.268 24.693 53.638 93.611 149.56 79.844 15.443 12.078 31.778 58.389 59.183 38.619 68.954 72.45 68.8 37.33 31.674 37.058 43.591 55.945 52.656 52.856 50.022 71.655 42.72 41.277 34.993 43.254 61.386 53.792 72.007 55.667 83.223 60.481 79.159 66.243 80.644 71.032 77.335 79.333 22.897 51.425 104.99 118.5 158.23 148.67 23.033 31.367 70.948 96.077 105.46 113.23 71.752 70.228 67.363 57.563 58.794 43.309 22.236 12.87 12.458 20.67 17.044 26.566 14.824 31.377 22.622 12.545 42.117 35.507 35.676 43.474 58.294 57.214 35.816 29.725 40.581 61.599 47.706 62.027 15.419 26.972 57.775 90.838 156.13 64.63 14.422 6.3776 40.673 54.684 64.43 42.793 60.66 66.132 12.856 16.757 11.861 18.615 17.139 27.902 21.743 24.587 7.7298 21.251 38.569 29.13 35.892 24.091 48.409 46.426 30.848 28.719 36.796 38.95 38.588 45.988 12.073 27.825 52.721 75.13 105.79 60.243 12.349 14.645 21.208 51.523 71.781 43.679 63.293 47.796 52.06 23.179 30.112 26.095 34.259 30.225 33.865 45.415 43.629 61.551 46.859 25.426 32.234 35.565 55.014 48.753 71.903 59.484 67.226 41.241 66.378 58.559 70.277 60.537 60.999 63.311 22.951 58.34 89.121 110.79 130.71 139.14 18.507 27.757 60.286 87.827 106.31 86.766 54.324 67.622 67.834 33.653 43.284 39.412 32.593 19.121 24.485 19.526 18.788 23.843 18.574 21.869 19.609 20.625 47.829 47.073 29.786 31.847 72.558 61.444 56.784 42.783 47.464 51.836 53.055 39.103 8.7034 29.787 54.502 106.81 133.78 78.549 13.21 14.327 42.686 64.37 75.524 47.254 62.003 65.18 84.247 31.329 37.36 33.456 43.218 57.041 54.065 46.559 44.908 53.28 41.067 33.189 33.489 43.097 55.306 60.992 59.79 72.96 62.806 67.304 81.505 68.901 85.042 73.723 70.847 90.403 18.007 50.326 94.012 133.97 141.27 123.9 18.561 31.561 74.258 100.12 97.464 102.67 59.149 65.617 67.532 54.5 49.596 51.295 21.405 16.311 14.27 15.305 12.278 32.222 19.118 28.627 9.6437 8.0545 33.827 25.837 16.267 21.114 48.559 56.909 59.395 28.26 62.579 43.567 43.258 41.036 6.6895 24.713 44.187 72.248 153.2 64.648 10.817 9.5861 30.388 60.446 62.175 50.797 61.525 61.916 70.451 29.013 43.191 33.77 11.957 19.173 8.9625 28.018 24.693 41.533 30.992 30.008 34.853 30.465 25.629 39.889 20.469 36.008 59.511 66.346 42.697 47.047 60.379 60.656 46.018 52.764 11.292 30.012 67.615 102.99 167.86 98.881 16.401 21.532 51.273 65.357 65.613 66.106 59.293 46.067 70.997 37.98 36.544 40.163 21.905 10.836 8.7388 13.73 17.671 30.716 15.182 20.062 10.283 16.9 33.774 27.888 22.32 16.358 46.562 61.649 33.767 32.299 40.2 44.279 23.619 31.67 7.746 22.528 49.93 76.821 133.37 51.796 13.601 17.939 41.599 57.693 58.887 34.544 59.203 65.724 74.563 40.488 36.5 45.811 17.888 20.18 22.232 29.504 39.506 31.824 31.044 15.612 12.01 23.31 25.467 33.276 15.944 26.092 50.281 57.338 24.306 41.974 58.164 59.548 44.091 52.874 11.554 45.244 74.271 100.75 119.99 80.023 20.125 28.222 52.217 59.526 63.13 48.82 74.944 55.976 55.639 39.62 41.848 34.245 20.199 14.716 14.332 14.807 21.668 35.882 21.943 18.708 15.411 16.96 25.051 31.516 16.205 22.694 55.105 53.572 35.443 38.613 44.376 49.557 38.273 55.298 10.571 20.037 58.647 86.481 137.64 69.535 12.207 16.69 42.757 44.705 55.595 39.76 75.383 61.68 68.133 37.091 44.334 26.623 20.694 21.132 11.778 35.795 26.462 36.763 25.234 24.92 21.095 15.839 20.567 20.833 18.52 25.788 47.793 57.763 39.669 34.214 63.114 53.202 59.855 60.592 11.587 38.881 64.121 110.39 128.33 103.43 18.868 26.243 45.387 54.344 49.239 52.299 72.268 62.232 69.539 41.572 44.065 40.044 18.307 12.052 16.798 15.264 15.708 29.069 18.152 21.72 15.652 10.788 32.768 28.224 16.535 24.69 44.627 49.169 31.238 33.281 50.924 41.636 40.841 47.771 11.034 27.032 55.464 93.531 150.85 69.223 15.182 15.537 42.982 49.235 61.069 60.118 71.2 76.571 77.641 35.415 37.346 43.331 13.731 16.891 9.2474 26.561 30.054 37.769 26.636 25.475 15.017 11.974 24.71 42.825 22.865 28.545 63.503 61.272 43.033 38.518 60.335 64.226 38.869 49.087 9.7211 38.144 70.244 101.22 154.6 99.551 19.912 30.673 46.587 57.851 58.398 57.019 80.703 80.309 65.967 53.174 44.744 48.139 21.999 8.723 14.124 16.837 18.782 28.627 16.279 31.639 25.431 15.776 40.302 38.737 30.939 29.634 61.304 68.179 52.663 45.372 42.893 60.357 50.831 52.262 11.906 17.168 61.589 110.93 148.53 79.969 13.416 19.496 36.312 56.756 53.89 33.081 68.384 77.42 82.609 47.789 35.461 46.583 29.196 22.159 26.137 31.468 39.221 42.232 36.125 35.651 33.481 34.269 30.554 42.574 26.918 32.119 62.492 71.162 53.081 39.487 79.093 63.29 67.304 67.517 11.683 46.165 79.632 128.98 160.29 102.44 21.633 26.879 45.628 63.081 58.852 54.642 74.138 60.8 70.9 40.15 46.621 47.134 31.123 33.52353 35.19492 30.07539 40.29552 26.23041 38.48692 22.66249 22.58756 19.19884 34.47119 34.58814 37.09544 29.17024 35.44334 26.99075 13.22095 32.83443 34.01337 33.75026 42.34086 41.60634 46.24915 38.83031 40.82201 22.66 22.18713 22.81032 23.29195 17.52691 19.83347 19.68946 36.78836 48.66079 44.88712 46.76087 40.41662 46.68597 46.10053 42.76746 18.27661 27.01638 18.27117 20.07734 23.78032 31.59603 29.50407 26.57366 35.80162 29.12223 20.251 19.20442 15.91239 25.02071 27.55646 28.15635 27.43958 33.53995 46.68913 32.88769 40.90189 47.05068 30.89849 39.74441 41.77824 19.99875 21.32849 27.91905 34.23523 30.27157 37.70196 37.64045 30.13108 38.18436 35.20906 32.40403 44.60335 13.89977 14.31121 9.882864 9.315511 15.78 9.987492 11.67262 19.94367 18.01388 14.74788 24.5 25.71964 24.5255 22.07374 25.64664 26.33913 21.13646 22.61637 27.3633 8.930286 14.77329 15.17399 13.87444 15.922 15.94522 18.46619 11.0227 10.79352 13.50926 21.17782 23.97916 25.68073 24.25387 25.89401 26.65521 19.27434 26.07202 21.0891 16.77796 21.184 20.57304 17.03673 13.02881 17.05872 22.16416 22.78706 30.42614 33.45893 37.35974 36.4863 34.18333 39.83403 31.51587 28.46928 18.06239 15.19046 16.89675 18.01388 21.80023 24.218 16.57558 10.12423 19.51922 16.5 20.21757 17.95828 20.70024 33.74167 35.26684 20.6942 18.8016 25.83602 27.17996 20.76656 13.41641 17.61391 15.70828 23.77499 15.24795 9.656604 15.01666 14.48275 19.66596 15.83509 20.694 19.94367 18.05547 16.66583 22.67157 14.57738 30.21589 15.53222 17.21191 15.90597 19.05256 25.87953 34.0551 18.50676 22.54994 33.84524 37.10795 29.87892 25.87953 24.31 19.36492 41.91658 30.02499 24.64244 10.97725 27.66315 9.513149 9.013878 17.57128 14.7394 11.09054 27.79838 12.90349 16.46967 16.74067 14.00893 10.06231 16.237 7.945124 8.696264 9.829802 13.41175 16.15163 11.09617 18.944 25.09233 20.6791 23.74605 23.577 12.83063 22.48611 17.36016 9.931012 11.77391 34.709 39.47694 37.53475 30.78265 39.23737 30.67572 42.79686 46.01397 35.55479 44.60141 44.5357 42.0272 55.69304 41.42808 64.11597 18.92466 14.11686 21.28715 25.57622 35.41388 16.42298 11.79588 7.416198 21.25021 20.17424 28.777 25.60134 23.25019 37.95862 35.80902 36.85493 41.90124 42.61288 36.5904 46.86759 48.12038 50.39416 57.54874 42.65309 36.86462 20.26256 13.03293 20.36103 21.18962 12.74475 8.518887 14.74061 24.12764 21.02719 39.696 34 33.94702 34.44706 25.20317 34.44996 52.72381 45.65742 45.46647 41.64373 41.2068 59.29081 43.90444 44.79062 39.33192 15.11952 10.92703 12.48199 10.82589 24.07904 17.32051 23.16031 23.16031 26.79552 26.85889 15.94992 25.54604 14.66288 19.77372 13.38656 25.56951 20.83747 12.00833 9.476286 4.538722 11.82371 5.366563 33.211 31.28578 31.97812 46.13675 40.89254 33.58273 38.50195 46.98936 44.92438 41.20437 52.08839 36.58688 51.57519 38.87673 46.68833 22.48555 11.41928 7.014271 12.86079 24.91184 15.06652 18.85206 19.02104 23.68966 13.73317 24.68603 11.48042 22.44103 33.06962 23.61356 26.14957 47.318 46.42629 44.71241 45.87374 59.36834 39.77688 57.87918 72.03471 66.90142 64.21682 74.64449 77.05323 57.8256 57.66281 65.96969 33.76389 42.65443 26.16486 43.4304 51.15076 46.34221 39.054 39.31158 35.72954 44.58251 56.31696 48.52834 54.98182 60.33904 49.38623 65.24722 53.36291 72.58512 79.54998 38.28316 82.81787 40.69644 40.26661 43.71727 46.18225 40.08491 37.82063 27.79209 36.18563 42.06186 30.94188 35.08276 40.10985 72.65122 31.174 31.69543 40.6694 32.08115 44.20633 31.00645 41.93567 34.99429 49.45301 41.36182 52.40801 56.23878 69.34119 46.24284 66.30988 10.87198 12.05819 15.9875 31.70489 32.769 33.51119 30.25558 19.00526 43.63026 41.97857 35.52745 48.63538 53.7829 44.40045 39.9975 58.68219 31.72381 62.89038 60.58052 18.89974 21.07131 15.44668 38.60311 27.50273 36.108 48.25903 43.66677 40.81227 55.13304 39.03017 55.35414 50.60992 49.97506 45.13079 34.78393 45.85928 58.47172 48.43484 51.85082 32.6703 30.1293 17.44112 50.36938 38.42889 19.16231 14.89645 27.38196 27.70865 49.04304 24.69643 37.80676 50.05219 56.15232 55.37351 53.66902 59.068 63.09756 53.36588 59.82507 57.74548 56.0604 60.37507 53.84697 61.18766 58.7087 56.85903 42.95179 60.83377 53.91216 54.68165 34.52606 31.39912 45.46286 45.06671 54.48609 37.43555 44.03754 34.015 41.93353 41.16953 49.84724 56.41206 44.71246 51.65144 28.53475 30.80471 42.06139 40.17586 45.10157 38.25995 29.39693 42.37776 37.1113 37.02059 33.71171 46.15297 46.54236 31.02187 27.62513 36.91642 36.33782 44.57518 38.64834 50.55192 35.25795 38.71664 37.54194 52.34051 29.30084 29.83799 30.41647 34.52754 42.78197 37.83079 47.047 50.63383 52.22284 56.61367 53.90855 42.96476 58.48467 41.75387 44.97807 42.94205 43.66469 51.05981 53.11276 47.6859 54.55997 37.36272 35.50154 38.90312 44.96484 44.26273 42.36062 38.45213 36.47209 10.025 9.246621 18.88121 10.21029 11.21383 14.30909 12.8355 10.79352 17.14643 17.13184 16.25577 13.51851 19.32615 14.90805 13.83835 5.894913 12.78671 11.81101 8.660254 9.823441 6.946222 16.88935 9.721111 16.26346 16.14001 18.561 27.75788 18.12457 21.43012 21.47673 26.35337 19.57039 50.88959 40.06557 46.12212 38.75564 47.26256 40.73082 39.59482 44.88597 21.43595 17.75528 19.98124 20.79663 24.82942 25.20417 17.25543 30.37269 17.63519 46.419 49.26967 49.33052 42.92435 57.12705 55.13166 62.80923 80.63343 77.26092 65.73622 74.44125 81.23577 80.68147 87.00862 77.41608 29.80352 43.00872 31.73326 51.83387 49.82469 29.79513 40.92371 39.13758 85.087 78.24002 70.42372 115.5617 103.5833 91.90892 112.8317 90.25381 78.09289 108.2335 98.55709 82.21314 105.0274 85.65337 88.0284 62.91065 55.03181 79.39616 173.32 134.6737 146.8954 176.8198 162.4731 150.6469 148.0827 111.5572 94.94472 84.39194 123.2933 101.7571 119.6296 88.03124 107.9641 126.7655 121.064 143.7167 127.6626 141.0496 140.9264 129.1878 152.4238 126.7902 144.8249 113.6299 145.6082 149.6554 136.9881 158.1977 161.6184 136.2011 121.9436 103.3671 144.0477 123.8134 75.301 71.16356 75.05354 72.07208 74.00638 61.02019 67.64988 54.75018 78.0044 58.47601 88.21379 81.51017 93.02931 68.20729 85.44532 49.03401 52.99232 64.16167 52.61954 71.75664 61.78986 52.43389 56.15554 60.05512 66.66797 57.01654 62.61913 57.27068 75.70524 10.607 17.39253 10.63015 10.5119 10.29563 10.19804 14.57738 23.33452 24.18677 20.70024 19.30026 20 21.27205 19.03943 22.63846 14.1598 13.94633 11.42366 13.0384 8.944272 16.98529 12.34909 13.60147 13.28533 16.55295 19.45508 12.04159 16.32483 19.96246 14.76482 12.90349 10.81665 11.51086 15.89025 16.55295 17.73415 13.94633 4.5471 13.66562 7.002231 13.51855 12.69828 14.60538 9.147472 39.21621 34.25398 38.3459 24.45347 29.43588 29.55218 28.38336 27.36869 22.93099 10.28699 20.38132 23.638 24.18175 8.886183 11.97169 8.789212 11.01137 12.76853 12.24309 17.67066 19.14153 29.944 34.58592 22.80899 27.03121 26.69528 34.01209 25.46955 63.99014 60.0405 53.98828 52.96337 67.8316 46.99389 56.17193 65.09545 18.74721 29.58604 22.94772 36.02541 27.57394 47.853 53.18656 43.4053 48.67042 49.4842 29.83149 48.48 56.74367 61.66596 53.24671 58.47037 70.5535 54.54072 57.06495 48.73299 33.07733 28.54992 29.67609 44.41802 39.80292 31.14055 18.86478 16.46311 35.65743 68.037 43.16874 59.87061 53.0076 68.36969 62.62931 54.75427 47.29655 24.06217 25.84697 28.82683 32.59724 23.81732 17.09605 25.4538 47.25227 22.46586 23.31581 25.26206 28.24011 46.88137 34.15898 31.26004 46.489 39.9059 34.5062 35.98985 45.87663 40.30553 42.48057 42.90356 48.70174 38.19072 54.02893 59.8035 59.69498 40.22242 46.33394 19.67315 26.18659 31.15969 38.90535 29.33038 17.73669 16.36056 82.207 77.2744 75.4214 83.20829 95.01568 55.13534 83.31883 86.41313 69.70303 88.80189 101.2906 81.20946 101.5044 92.80234 102.551 52.64744 59.14396 73.70755 57.16382 56.819 57.97596 76.33954 78.06035 77.3327 72.93919 86.25006 99.93964 90.07775 80.81177 90.83674 77.15249 99.07846 94.00278 86.30873 39.24546 55.61202 52.14535 51.22253 62.70044 55.52815 66.29899 81.567 72.83978 73.17806 73.00988 78.37396 62.73755 74.57664 88.25704 72.79475 81.82338 81.38222 93.73673 89.99672 89.99018 92.01466 48.13727 52.18478 51.30918 58.77476 74.86892 65.82568 47.85216 14.79 28.19574 24.09876 18.91428 25.41161 23.02173 38.14446 54.32541 59.10584 54.28398 59.10584 50.97794 61.84658 54.307 47.66288 25.23391 28.95686 31.233 28.24447 39.22053 13.22876 19.18984 19.37782 23.17865 18.47972 13.72953 17.55705 41.17645 32.14032 33.95217 36.89851 42.24038 18.30301 31.83159 31.97264 39.53479 39.35416 21.506 31.87868 25.56854 21.77728 33.35041 42.95637 50.26927 63.14665 56.59284 64.70317 48.09626 61.54267 57.81652 62.98016 64.04881 36.10402 26.49056 29.16762 36.44859 28.25774 15.19046 15.07481 18.20714 22.275 20.24825 18.05351 21.73631 41.78521 24.84483 28.12747 56.99514 49.9509 50.53629 54.40331 62.83326 53.58532 53.83199 62.30456 29.92634 28.6043 35.14352 30.07006 35.85275 14.73212 20.32227 18.57066 30.33172 25.60018 22.30238 33.64528 32.95458 41.48538 40.83987 19.395 23.0559 19.58786 12.08705 36.65801 21.28382 42.06195 65.88564 58.02905 66.05837 58.80761 74.29599 72.82883 63.51251 66.33521 18.73379 16.35771 17.31018 30.2672 20.60576 22.26462 34.73846 28.64703 17.168 18.16631 9.126913 13.3797 23.27935 17.57847 37.65385 69.66731 75.92333 68.42288 65.67099 73.38624 75.63363 71.84168 78.851 12.31341 14.59015 10.48435 32.94067 15.751 13.91752 15.44127 10.42857 38.35831 23.51628 26.89665 54.26978 66.6063 75.60898 63.5061 80.63836 69.66938 59.80273 71.08688 15.38244 10.53476 12.04383 34.26308 27.80266 15.01448 34.979 31.08456 33.52238 20.21757 41.84196 33.93376 30.58594 54.75856 48.53349 39.03524 44.50281 47.71268 40.70319 41.51205 58.50855 22.41093 21.23087 20.16185 27.59529 30.52048 24.56115 31.448 35.21008 32.94313 25.68073 30.18692 21.37756 26.8235 39.98125 36.42458 43.41947 40.15595 45.11652 47.56049 42.08919 48.54379 19.55761 20.70024 22.88012 22.09638 22.52776 24.23324 16.38597 16.03901 24.92489 18.79495 18.04162 18.37798 24.87971 38.42525 21.78302 33.23778 38.48376 35.847 23.05428 27.16155 19.84313 39.16312 31.64253 36.36276 56.3427 57.79057 54.22177 52.57851 66.33438 60.79885 46.62885 50.0025 28.59196 26.05283 27.59529 27.35416 33.66749 24.01041 23.14627 37.057 28.53507 29.62685 26.98611 34.82815 32.14809 30.91116 44.87204 47.58676 48.64925 44.84696 55.09537 39.84658 56.62155 44.32832 32.93175 20.4817 25.54408 31.18894 26.35337 15.73213 11.46734 21.03568 18.88783 30.29026 15.40292 23.98437 38.43826 32.81768 27.19375 46.76003 35.14612 37.97 30.78149 31.91786 30.92329 39.2492 20.89258 33.13986 34.86402 26.65521 22.75961 22.50555 19.83683 45.13037 17.19011 34.85685 41.77918 28.80538 26.32964 27.48181 41.18859 31.69779 22.91288 18.24144 26.43861 31.42849 17.97915 53.512 35.58792 48.24158 34.67348 52.12965 42.13668 41.27651 32.38055 28.08024 22.43881 32.31099 26.11034 35.17812 19.67867 31.10466 20.30394 20.26697 20.03746 19.84313 34.16504 31.71356 14.22146 24.86463 31.33289 45.43677 27.07859 28.985 32.79291 24.49235 22.26264 23.5876 17.02572 26.88169 46.62483 38.65715 34.53802 28.55039 33.38974 35.61425 46.65699 51.10651 17.39612 23.21368 13.34635 23.0353 25.08735 13.01442 30.701 30.56375 30.93542 34.32617 43.30622 39.58355 44.16042 39.35371 37.05016 54.88039 51.62502 53.10636 52.96225 43.41001 56.70097 17.72005 11.11627 18.63177 16.83109 35.75112 25.90091 14.02039 16.59174 27.54736 32.08694 21.04757 34.986 38.71877 37.48714 43.40671 49.50036 23 35.35534 50.29484 40.7466 51.31833 57 55.73919 59.34163 47.48383 45.12997 18.73881 12.32303 20.36453 37.70184 33.91376 26.88069 13.83577 17.58652 28.89884 43.73622 48.479 47.78284 43.97044 41.59567 43.49713 50.63003 41.833 45.6377 55.16521 59.82642 50.87829 49.683 56.79084 52.93014 63.71499 9.143304 11.89117 8.342661 11.04536 4.939636 37.44863 30.74411 30.47294 36.94049 21.76695 26.64958 58.643 47.69486 38.23349 44.85309 39.52468 44.04316 54.90902 65.96666 53.20338 60.29594 60.67949 53.34604 54.56922 47.02765 46.8615 6.033241 14.87279 12.22293 11.01817 20.61068 25.48725 24.82338 26.49906 22.07261 22.71563 23.09978 22.56546 28.16381 21.85864 21.61018 18.85736 22.88668 17.21627 19.19896 7.823043 55.685 46.52741 42.48058 39.00256 68.7968 59.88656 66.3988 63.44289 68.29788 56.22277 52.63459 75.18776 65.56066 66.36415 69.14767 42.88823 38.8973 46.38965 67.20417 43.89533 32.02187 32.10607 27.81367 39.94496 55.73688 65.955 37.72797 82.26664 42.43112 64.73175 64.3506 56.81197 65.54083 81.38182 56.03749 71.49406 65.62164 75.50629 71.99861 83.23941 38.55905 55.69919 33.68679 34.59191 44.47696 40.53147 25.23886 25.05195 48.94691 34.31326 30.17284 37.34434 70.17122 52.93581 65.00769 70.22535 58.28207 40.09489 44.24251 39.88734 52.29914 57.92754 53.072 37.73857 35.98611 38.98974 47.4173 35.98889 39.90238 59.654 53.39288 64.3133 62.89674 72.27724 68.80552 48.70113 68.68479 18.27019 21.29319 13.01538 25.88049 29.66142 20.24846 12.17374 18.25377 36.50479 29.41088 36.409 46.8807 32.08738 32.80854 48.21411 37.97368 52.07111 51.06662 53.30103 58.60887 54.10545 60.26608 51.34783 52.87911 59.18953 28.56921 14.49828 8.843076 41.83061 31.49921 34.68141 14.99333 16.72722 34.45287 34.34822 15.99375 38.64971 57.40906 45.24157 30.49918 55.51576 38.41354 57.324 50.84648 64.36461 62.7542 56.84764 62.09166 70.2187 83.63505 68.07733 61.23796 63.8465 77.52023 69.75022 65.41476 79.85943 49.47228 28.04694 29.74277 43.49959 45.49018 34.07649 29.80754 27.59506 45.39116 45.92305 37.69515 47.57026 41.47718 50.78885 57.42149 69.29199 58.61813 38.76205 70.531 72.52215 58.54797 67.82487 86.51173 68.07878 73.72404 62.27132 67.84098 68.38756 54.65185 69.02843 78.30387 59.29385 78.6532 46.05515 47.626 39.86562 47.73633 52.00224 46.49896 44.91775 41.23435 56.20179 61.85257 55.58498 47.44403 54.98303 62.10443 51.06118 62.21982 55.23042 42.21571 50.99447 47.47472 56.70182 55.98693 58.264 53.9951 63.04109 51.1597 66.16038 50.41728 63.6746 51.07424 44.62567 57.46056 47.82925 50.54818 56.73 55.85227 63.42404 29.90023 38.28347 40.45682 46.05863 60.228 60.49518 58.10243 58.14058 74.35935 57.94247 67.32869 59.05167 53.59443 63.66799 48.28172 67.23709 61.74021 55.82206 64.3326 45.89693 40.29929 42.71524 53.45227 64.16985 44.45149 44.23524 49.14979 52.59231 61.45166 50.89269 53.96361 41.20191 44.92455 51.03905 61.96513 45.58232 39.89546 35.40417 39.34315 60.36107 52.93222 9.6825 14.61164 25.70992 14.25658 14.66288 19.44865 17.0147 7.141428 15.6365 19.9374 14.08013 20.8866 22.01136 14.5688 14.1598 7.599342 13.64734 9.912114 9.124144 38.442 41.6143 38.2034 35.83643 48.01302 39.19503 45.50824 60.38833 68.4087 64.53875 50.92887 61.23316 51.25427 50.12484 58.51923 35.75612 31.99609 40.53702 46.03531 44.18993 61.553 63.90031 56.59064 70.41129 65.69817 64.02148 75.4586 96.38594 96.74838 96.92136 94.39942 104.7306 104.324 103.2945 104.0216 37.67957 57.97198 55.02499 62.0665 65.92609 111.42 95.31264 117.6977 118.311 125.862 120.0927 131.5076 87.05889 89.57399 104.0973 110.8388 122.9837 116.6244 104.8642 120.1863 75.28944 72.59132 79.15491 91.5833 104.3528 83.68244 80.88881 72.83715 104.2809 180.77 145.2265 162.3499 188.8333 171.1184 131.9782 165.3133 127.1908 106.8352 99.47613 145.4381 129.244 118.1196 105.513 127.3283 148.2068 115.8555 144.6807 127.6215 146.9132 118.78 105.2121 103.6874 101.3986 109.4736 114.7082 107.3657 114.0517 95.07103 86.53523 108.3453 115.23 107.5457 93.80628 103.2313 84.84961 75.65107 68.52665 93.45176 88.62128 100.9992 80.40919 72.75474 11.336 13.92839 13.92839 7.615773 16.14001 15.70032 14.31782 26.95366 27.10166 18.56071 26.31539 26.23928 21.96588 25.94224 25.34758 27.6134 19.72308 21.09502 20.0125 20.80865 21.26029 18.43909 17.49286 12.74755 17.02939 17.72005 16.76305 21.26029 20.61553 18.56071 27.01851 10.927 19.72403 18.28645 25.52676 24.65553 12.76853 23.739 47.75744 44.30636 45.38942 44.69083 44.36115 46.9177 37.38 57.70979 25.66073 21.78069 31.65401 31.61669 26.50961 36.606 31.20048 32.02402 33.88543 50.58267 43.47098 40.72407 75.35178 72.13663 62.39361 65.81047 81.64838 65.60587 85.45119 69.42975 39.69506 40.21888 35.77432 36.46195 41.37035 22.58641 18.57014 27.96594 31.54771 35.45231 37.80336 37.03482 43.49462 56.21969 44.23395 46.09809 55.48263 43.58337 30.85719 48.28994 34.54652 40.76202 54.379 59.6309 53.40206 74.39136 56.2367 55.37149 58.47921 64.66605 83.58465 65.25101 65.93018 66.87941 78.35349 63.16822 68.3025 41.74729 46.10137 36.1808 49.79739 49.15024 47.95014 32.66613 28.98783 39.14103 49.34063 31.92839 43.71277 79.54905 77.26183 69.25234 62.10129 67.40835 50.21141 44.70099 44.54905 45.75542 51.17828 78.818 73.47762 81.8822 58.16476 71.74029 79.31383 71.01226 64.5972 53.06071 37.80275 35.4047 30.70229 38.68214 37.68143 48.0107 75.92238 22.26827 44.92602 33.66645 36.08918 74.82655 40.49127 62.91005 45.86712 45.86712 44.35119 38.76189 84.41613 68.26504 63.976 56.92372 57.23412 68.86218 64.14354 58.59646 71.48034 78.45936 71.34014 74.55945 58.16603 74.17805 65.72447 67.31744 75.59318 53.75821 39.73529 32.8404 50.12076 41.36338 57.61716 50.07749 39.58331 51.25682 54.49055 78.677 86.34861 81.02097 88.56813 81.10023 86.69793 83.04284 79.04566 66.40927 82.51667 80.67526 92.73681 96.65808 90.14785 86.22908 48.21716 52.41076 59.58864 65.93725 65.16 69.16074 63.23811 84.38677 71.75974 71.46705 72.96682 76.85434 67.8844 84.33021 88.72437 82.58245 97.863 78.66008 84.16483 52.85208 56.30461 50.96493 64.53192 59.01392 74.667 77.32356 83.36665 88.19548 82.85811 81.44887 77.19396 57.24897 82.29208 90.21114 96.72228 84.9623 85.42324 91.02974 74.15295 45.30319 55.1137 56.66488 52.28777 62.84918 45.16567 46.78993 72.99388 72.86382 25.99 33.8969 23.44142 40.23059 37.53998 42.02678 47.54209 60.9713 50.30408 63.30087 55.88604 61.86477 64.81898 66.04733 56.3671 30.60229 21.59861 22.10204 29.74054 26.54713 26.16295 17.53568 31.472 30.52048 35.75961 42.13965 50.13482 32.84814 48.65182 56.87047 64.27675 66.38712 80.68922 60.1602 63.02777 52.82992 67.81961 35.2881 25.40177 26.20115 32.7185 41.27348 29.33428 39.82462 22.42209 32.04294 30.78149 25.31304 28.78368 53.64466 51.16151 45.16082 60.03124 50.09741 34.99643 27.90161 28.09804 40.45368 46.68779 25.157 41.39042 34.89201 27.71402 34.33489 31.85641 46.41751 56.17868 54.76712 66.77478 68.91273 65.32207 45.63318 60.52524 59.31724 20.66338 40.35355 34.76198 41.41723 39.09598 26.07513 28.53525 19.10739 37.49474 36.12187 27.18159 42.24828 43.88415 47.09286 45.43896 48.97049 46.88119 28.59037 42.32757 25.46496 54.26152 45.0277 40.20789 17.25467 18.23899 31.625 41.31305 7.454333 16.49486 10.37217 20.75803 10.40375 20.34087 19.93435 14.67622 15.87331 25.40965 13.5631 21.80644 18.25077 33.22091 27.01441 27.52192 24.4146 26.18002 Independent Biomarkers 29.072 36.107 16.039 21.743 18.007 23.659 18.534 16.823 17.871 25.391 30.458 32.274 34.511 66.927 59.558 36.905 57.893 58.696 42.414 59.392 51.238 12.43 27.875 50.929 85.131 139.46 70.252 15.0712 17.62772 16.87899 21.94292 25.44539 33.54797 20.2608 14.75635 21.87464 9.785193 14.18626 14.45683 15.34601 14.45683 12.4298 9.578622 13.87444 14.02676 19.48076 26.1247 19.65324 29.71952 14.07125 21.36586 26.73013 14.5 14.13329 25.03498 19.98124 28.95255 10.98863 28.79236 14.62019 12.57975 18.73499 17.47856 19.43579 25.224 33.58943 20.70628 16.80774 21.37756 23.64847 19.8809 28.90069 14.55163 21.48837 31.72932 24.38237 32.85575 23.25403 7.5 15.47579 15.67642 19.48076 7.36546 27.43173 11.86381 19.38427 23.33452 7.27152 18.07968 14.44386 7.721723 9.387492 11.69936 11.12991 12.46495 9.585145 18.27909 17.11359 6.661456 14.67566 20.75753 18.36096 11.46189 12.17066 16.09736 18.87127 13.62443 6.77179 33.56869 41.18252 30.90076 36.63722 33.97478 25.55945 9.561829 6.279217 22.8567 16.5702 18.9473 32.14921 19.9374 12.41974 15.04992 13.17194 13.00961 16.9632 11.68332 16.7556 16.36307 15.40292 17.0147 12.10372 12.82576 17.29884 16.31717 17.38534 28.28869 31 11.7686 9.246621 13.81123 13.36039 10.12423 14.36141 13.38843 9.759611 15.37856 20.5548 14.73092 14.79865 15.59647 14.05347 12.09339 15.10794 17.60682 22.43881 27.04626 33.84893 8 Populations = 40 cohorts x 2 37.809 35.658 18.432 23.838 13.148 67.819 66.874 62.567 66.342 77.612 77.178 51.348 66.135 51.276 53.715 57.366 61.874 9.6825 43.442 77.618 109.82 120.88 79.379 17.464 36.788 57.485 51.994 28.345 47.499 115.91 98.961 104.75 85.917 81.837 86.753 67.976 77.151 70.939 40.666 46.677 48.099 50.316 22.683 40.481 45.151 63.812 79.571 73.479 66.569 97.536 95.571 81.406 51.433 81.305 78.316 60.004 75.348 22.051 53.446 99.027 97.494 138.44 99.172 28.018 40.116 68.289 73.843 37.108 73.628 96.652 85.606 105.02 95.159 81.482 82.471 37.3497 21.03568 23.29163 19.39716 24.5204 28.11583 17.0147 25.01 16.62077 11.80042 10.87428 15.52417 34.49275 17.30607 20.6778 39.58174 27.16353 29.3355 29.3355 31.90163 35.08968 32.92632 19.02254 19.84223 18.89444 20.02498 18 31.806 44.797 60.934 35.819 29.98 42.819 50.573 42.575 42.037 13.248 24.346 50.302 80.553 133.9 58.994 11.18 18.85 29.253 31.469 39.359 26.788 65.754 58.084 79.177 39.316 38.613 37.132 40.486 33.296 39.336 13.775 28.513 31.788 28.697 22.666 30.455 20.497 33.63 35.942 47.108 38.181 54.697 59.245 39.299 45.288 56.873 58.203 53.082 53.389 18.055 39.462 60.659 103.83 152.21 90.437 19.039 18.281 49.472 43.154 43.401 50.117 81.125 64.343 69.974 40.896 56.734 37.411 19.0683 15.76705 15.20526 11.97497 24.75884 1.788854 24.4663 23.74447 41.67253 38.04997 31.02902 46.10206 59.96832 57.04384 58.47906 69.16936 61.28948 41.65093 38.20733 41.12907 40.58325 52.32017 61.4817 62.71682 65.59726 54.70283 42.96277 33.53207 36.20773 40.67677 55.75661 27.7092 8.988882 16.41341 18.6494 30.09651 19.32356 20.02498 24.61707 52.43472 35.28739 33.09381 54.65711 9.97998 13.60882 6.244998 25.27845 14.22674 21.73937 32.64966 27.20662 18.55802 56.77147 50.16373 52.72191 16.04992 14.29685 24.08734 36.35932 28.32314 46.5532 18.17691 16.04369 15.78607 25.34956 29.27798 42.2991 32.94898 31.79945 39.99551 31.54456 43.85439 52.0882 39.2801 33.37011 40.92891 66.97515 43.16264 49.0809 46.50134 55.2022 37.24087 50.62645 41.95631 54.11239 45.08539 57.92412 48.9023 46.39214 39.77541 44.48023 43.95849 46.38778 46.49311 50.12646 39.69487 28.72887 33.16661 38.21615 51.11573 45.28257 12.5996 17.72005 6.30476 12.09339 9.513149 12.68858 7.449832 30.4836 26.73948 30.52048 25.76335 28.82707 36.15591 45.8503 38.87801 40.62635 52.86303 48.56439 61.4451 52.31396 63.16051 55.96651 37.52999 42.64094 51.74456 45.11375 60.79062 81.5935 98.30437 68.15424 77.66756 99.77475 95.13937 112.5722 113.5859 94.04919 69.57909 74.47483 88.38835 101.3435 84.91614 9.5 15 12.4298 16.17869 18.85471 11.06797 9.287088 24.5153 31.47221 30.83018 27.39526 24.80423 21.87464 22.913 44.975 74.748 148.9 61.475 14.16 15.914 42.059 51.756 58.343 48.115 61.43 78.272 77.795 43.399 56.749 49.131 14.656 11.193 9.9239 34.304 37.865 39.781 33.667 28.714 34.619 20.14 29.27 46.773 20.876 23.074 62.556 71.402 69.52 63.325 65.245 53.858 58.372 67.474 10.464 34.253 60.986 83.46 157.74 87.163 13.601 31.688 42.757 62.087 70.717 59.472 67.459 68.407 67.804 58.267 57.308 56.349 43.937 80.47 97.117 90.313 64.475 20.555 25.326 60.495 45.946 26.639 43.726 89.833 82.17 105.6 96.946 89.803 84.679 63.527 71.948 64.982 49.186 54.143 61.956 48.875 18.594 36.118 32.926 56.455 64.581 63.519 66.934 78.238 84.8 69.059 59.319 77.712 67.939 63.884 73.181 17.428 60.791 104.87 94.128 89.72 110.73 24.352 58.257 56.435 75.21 40.192 52.359 89.183 96.717 82.292 88.395 89.15 81.672 29.6395 70 99.0568 65.09224 55.07268 88.73697 125.994 66.4619 85.21527 58.09295 46.77928 64.36105 61.24258 65.59108 66.11525 10 15 13 11.933 30.548 24.788 40.324 23.697 82.103 74.08 75.443 24.362 35.718 35.932 33.573 20.499 16.63 18.908 33.384 28.614 23.356 33.996 40.583 14.987 45.073 50.581 37.36 49.703 44.808 52.604 47.722 40.388 66.063 75.463 68.944 72.708 14.925 40.509 55.505 103.04 159.18 84.098 13.601 14.819 26.534 40.552 49.43 45.751 73.126 86.904 68.611 28.805 48.094 41.328 10.168 36.104 45.631 49.327 31.315 66.421 68.206 67.729 36.773 40.725 47.624 39.681 37.002 35.046 27.884 23.885 31.165 29.458 24.062 33.593 23.057 32.816 55.527 29.189 36.837 44.141 57.435 26.721 25.683 53.806 57.716 52.274 60.882 17.015 50.666 73.121 82.485 149.51 85.222 14.56 18.66 39.119 56.644 48.435 51.258 72.577 66.883 75.488 47.334 49.026 38.957 14.006 30.446 31.557 29.042 33.218 65.963 58.253 64.208 41.911 35.623 45.137 16.641 8.1968 8.8659 20.815 26.467 38.056 23.292 19.615 14.335 18.911 23.065 27.923 6.7676 7.2388 30.578 47.233 31.138 29.903 39.472 44.065 44.381 39.466 14.68 39.44 58.724 97.779 139.03 76.286 21.691 24.695 27.966 43.41 34.654 34.254 74.855 56.177 59.62 45.089 48.518 49.317 12.5883 17.05149 15.74463 26.51496 26.50964 15.66273 21.09095 18.88609 16.35877 32.1081 11.93558 32.78759 53.37024 44.89016 37.01878 46.38627 39.92931 38.70041 32.87945 20.72684 42.717 25.64258 43.54979 64.77998 72.99386 64.34338 58.45462 68.85726 38.63154 25.63158 37.48485 41.6844 34.03686 32.1957 50.25222 73.55645 65.69882 66.53402 63.96304 17.733 23.68099 24.67766 16.8942 34.26302 51.53954 50.82945 55.12317 65.409 58.91981 53.53396 66.66848 74.52231 73.31617 48.78896 68.91542 52.12094 80.11895 65.31537 64.85177 69.89072 51.00029 53.17066 51.74519 73.57255 71.56379 52.4305 82.52974 64.20305 66.64922 55.59278 57.27973 68.46805 87.63542 76.96896 73.35495 55.93869 56.68382 56.99322 55.29891 58.03291 61.3031 62.95515 63.03293 55.75211 61.89969 78.8821 67.45445 12.3563 21.73242 15.98456 31.14563 33.6892 44.1598 35.07652 38.8159 62.6571 53.55895 27.12506 37.29167 36.35419 32.32709 53.2442 37.24369 33.96317 55.2249 23.097 32.53607 48.23595 77 74.9856 70.09205 75.48924 70.07004 47.38219 67.88298 69.38271 65.09727 23.822 28.588 31.893 33.615 51.529 39.445 59.962 44.255 61.284 51.887 43.396 58.784 40.378 76.265 58.406 85.033 58.619 74.377 62.153 74.675 73.346 86.017 84.317 68.828 77.922 14.748 51.308 97.241 117.63 158.13 160.32 18.868 16.739 58.128 96.524 88.279 114.34 65.991 75.59 77.429 50.698 39.326 46.466 30.6635 28.32402 34.0147 28.52192 44.39313 44.37623 41.2977 45.10543 48.05726 43.0981 50.13957 33.31616 33.32031 36.23743 28.8184 38.72015 47.326 36.18011 34.11744 33.7911 35.88 30.5385 40.46111 34.26707 37.62484 14.55782 16.57807 19.91043 28.32552 22.58707 19.19956 22.54955 14.59012 28.08197 28.41862 19.0969 37.93925 32.26874 30.32533 36.98932 15.93075 28.68016 23.85006 24.99085 23.68968 11.78643 4.292813 14.21463 21.94744 32.25956 24.717 29.22879 37.03304 28.65065 29.52574 39.35585 24.24074 14.43726 15.82083 19.83764 31.10288 12.49 19.9875 20.35927 23.98437 21.85749 36.43487 24.5815 29.09897 35.74213 36.84427 45.65906 31.58718 19.05256 29.43213 28.34167 27.27178 24.1628 14.99384 20.29269 12.1353 13.77509 13.64712 20.60466 31.33154 22.5 24.36186 17.73415 21.43012 24.18677 46.0923 31.13278 34.56154 30.51229 29.57195 22.41651 20.0624 24.47958 27.64959 22.24298 26.83282 34.7491 25.43128 28.08469 21.25441 26.83747 41.94639 43.14221 49.68652 41.00305 25.0699 31.37276 16.92631 20.71232 37.89789 17.05139 32.58834 33.30916 24.91486 25.0699 31.12073 21.09502 18.77498 32.87096 16.57558 22.39978 18.41874 11.18034 41.25227 18.9374 13.00481 21.73419 22.12182 31.77853 22.90469 33.78794 21.83174 16.72947 11.25278 9.387492 22.80077 31.79819 29.0566 34.77684 31.61148 34.22405 34.11116 33.43223 26.25425 17.95232 27.57069 32.92199 33.16194 25.2728 24.35452 45.49254 36.89173 36.81421 36.67619 40.50749 28.95563 34.34489 17.70391 29.99762 29.19393 31.2666 21.2132 25.44799 21.84949 34.54562 18.05547 12.77498 13.98571 11.89117 6.723095 10.13903 41.4367 28.5 Correlated 39 18.8016 20.041 35.124 29.123 25.577 32.775 63.337 72.507 53.833 53.158 55.95 65.235 51.955 64.444 10.747 46.462 57.734 87.103 153.89 79.817 19.925 28.222 41.295 77.605 54.476 75.724 70.146 63.309 71.303 56.292 57.983 58.349 10.0312 14.20827 19.67549 21.3682 13.53514 39.8748 50.018 55.44186 59.72604 46.70546 61.73168 49.3518 46.54031 30.28861 39.1561 39.91491 53.6973 Fully 15.8619 42.23979 39.47911 39.09476 46.05866 57.26605 27.5971 33.34367 25.37321 24.78306 35.01143 37.66431 36 10.45945 21.52673 32.96058 41.28196 42.2129 30.02956 49.67972 48.77136 55.8218 44.67576 41.06567 44.31425 53.82613 56.86185 47.9141 56.48717 41.47728 41.68698 56.41195 61.946 44.60033 38.17652 40.33538 38.86472 57.40778 51.68197 Unexplained 14.3788 12.30853 15.32155 20.59733 18.98684 18.53375 30.6635 25.59785 38.1248 69.87489 49.97499 62.19727 61.09214 44.14465 66.22877 66.23254 71.07215 72.34984 83.49551 65.28017 46.89616 49.64121 100.307 81.39564 94.63086 99.66695 99.95749 106.9871 156.305 136.9033 167.4074 143.2925 152.6663 128.6954 143.8011 178.6246 145.4089 180.5443 173.8606 159.1674 148.0616 136.6885 144.8206 149.6713 137.0711 103.091 102.7207 80.60832 82.77928 92.60953 91.62098 20.5061 16.02342 8.616844 17.53568 9.565563 13.22876 14.66288 9.407444 24.995 34.17967 26.67864 38.11168 37.3497 32.01562 38.91979 27.40894 36.72193 34.24909 30.84639 37.61981 31.85122 34.42383 37.61316 13.7659 12.35921 18.04162 16.68083 50.9436 60.08328 47.31807 132.632 102.5171 96.20551 80.07809 82.49394 98.27004 93.63493 86.7396 111.5541 87.00623 80.39023 71.23042 22.7706 27.58623 19.55761 31.40064 21.09502 78.5985 111.8787 84.55756 10 10 25 25.387 15.287 39.688 63.267 108.29 64.664 85.247 92.025 74.099 38.02 52.034 43.039 15.537 28.293 45.119 75.738 44.176 57.087 58.549 67.425 29.845 44.404 25.61 30.112 56.145 61.872 70.341 63.901 91.014 83.66 74.652 72.026 64.23 67.078 10.3596 19.72403 23.5123 17.68472 19.30687 29.77363 21.26622 37.07785 26.65067 26.54329 27.44684 40.08716 25.82306 31.48999 25.39211 23.0009 29.68237 67.8415 67.70814 66.26611 75.1667 32.81376 57.19868 51.25671 38.35364 42.1508 49.5799 49.5799 45.67361 51.53363 52.2954 50.64016 52.90685 75.51251 67.96416 68.14079 64.91941 61.0871 54.14814 57.71006 65.42981 69.24639 74.37791 58.39436 76.77518 59.46336 73.56583 71.98423 80.65294 77.27151 53.69545 52.06021 46.55756 59.79139 46.3583 58.25807 51.12826 70.37357 75.1436 60.52434 61.67986 76.03123 69.92481 78.51487 67.947 54.50716 71.32261 74.56113 73.66356 26.8235 34.64823 24.91987 26.02883 27.46361 45.89662 37.23909 39.51582 48.33477 40.43513 25.10976 29.20188 30.54096 64.2663 70.4507 63.89326 82.17 85.66469 79.64009 50.31529 49.11199 65.63619 61.00061 62.98918 50.0806 55.02804 60.91714 67.60156 65.91877 39.2269 37.15508 35.3011 UKPDS33 Conventional UKPDS33 Intensive UKPDS33 Full ASPEN All Placebo ASPEN All Atorvastatin ASPEN Primary Placebo ASPEN Primary Atorvastatin ASPEN Secondary Placebo ASPEN Secondary Atorvastatin ASPEN Full ADVANCE Standard ADVANCE Intensive ADVANCE Asia Standard ADVANCE Asia Intensive ADVANCE EME Standard ADVANCE EME Intensive ADVANCE Eastern Europe Standard ADVANCE Eastern Europe Intensive ADVANCE Full ACCORD BP Standard Therapy ACCORD BP Intensive Therapy ACCORD BP Full KP 20-34 KP 35-50 KP 50-65 KP 65-75 KP 75+ KP Total NDR 20-34 NDR 35-50 NDR 50-65 NDR 65-75 NDR 75+ NDR Total AHEAD Control AHEAD Intervention AHEAD Full ADDITION Routine ADDITION Intensive ADDITION Full UKPDS33 Conventional Correlated UKPDS33 Intensive Correlated UKPDS33 Full Correlated ASPEN All Placebo Correlated ASPEN All Atorvastatin Correlated ASPEN Primary Placebo Correlated ASPEN Primary Atorvastatin Correlated ASPEN Secondary Placebo Correlated ASPEN Secondary Atorvastatin Correlated ASPEN Full Correlated ADVANCE Standard Correlated ADVANCE Intensive Correlated ADVANCE Asia Standard Correlated ADVANCE Asia Intensive Correlated ADVANCE EME Standard Correlated ADVANCE EME Intensive Correlated ADVANCE Eastern Europe Standard Correlated ADVANCE Eastern Europe Intensive Correlated ADVANCE Full Correlated ACCORD BP Standard Therapy Correlated ACCORD BP Intensive Therapy Correlated ACCORD BP Full Correlated KP 20-34 Correlated KP 35-50 Correlated KP 50-65 Correlated KP 65-75 Correlated KP 75+ Correlated KP Total Correlated NDR 20-34 Correlated NDR 35-50 Correlated NDR 50-65 Correlated NDR 65-75 Correlated NDR 75+ Correlated NDR Total Correlated AHEAD Control Correlated AHEAD Intervention Correlated AHEAD Full Correlated ADDITION Routine Correlated ADDITION Intensive Correlated ADDITION Full Correlated 22.682 6.3796 14.099 19.887 17.27 17.103 11.822 32.535 11.843 12.674 13.974 17.134 26.226 24.22 15.277 8.5206 26.458 11.967 9.5935 28.51 25.823 21.49 33.113 31.901 29.692 14.874 9.0692 18.822 9.6566 39.326 19.404 16.7 12.912 9.7907 20.586 15.382 25.996 20.288 10.555 20.722 18.717 24.513 28.086 31.84 6.2048 5.7663 26.847 42.196 104.82 31.046 7.2801 7.8668 9.7274 21.346 3.9405 19.38 24.597 24.383 24.81 23.157 19.013 22.073 48.165 63.435 61.347 24.233 28.116 31.173 31.105 16.016 19.474 9.6372 19.42 22.659 25.609 25.9 27.68 24.896 24.548 22.786 28.816 30.271 26.849 24.651 14.221 22.578 28.805 51.549 103.01 63.004 16.031 20.216 23.483 38.742 36.603 47.645 23.089 25.176 26.582 18.822 26.763 26.809 31.04 21.355 39.376 15.819 11.158 12.278 10.886 47.112 31.056 15.91 8.9123 14.208 8.8657 17.012 16.882 31.222 19.473 20.474 25.727 33.4 29.702 31.108 7.1937 11.779 16.016 56.002 92.9 32.13 7.0711 11.971 13.136 10.841 9.646 3.1788 28.559 27.679 21.218 20.031 16.926 16.198 50.279 62.648 58.247 17.479 24.119 28.605 34.044 24.734 41.228 22.229 13.12 20.539 40.861 24.417 29.168 24.54 26.941 16.715 41.974 33.887 31.303 31.038 9.5656 28.974 45.484 56.013 108.66 58.727 21.467 21.808 28.19 7.9687 11.554 17.342 10.062 42.388 24.254 13.514 11.563 16.941 11.55 7.4027 18.499 15.113 18.804 18.401 11.571 27.157 31.861 29.036 4.3012 4.4159 20.18 57.441 119.7 45.529 3.8079 3.156 11.555 15.708 6.5967 20.93 27.981 20.439 32.673 12.01 19.072 21.873 44.354 49.906 51.943 24.403 18.668 32.519 27.505 23.049 25.647 11.837 8.7096 31.767 16.31 24.36 20.435 21.119 15.881 19.095 27.452 30.396 24.947 21.632 12.47 20.261 31.949 53.033 125.86 55.629 8.5147 8.148 23.262 33.376 42.715 52.113 26.095 24.89 23.507 17.117 20.779 23.206 58.797 44.647 46.482 19.558 18.688 15.524 19.481 36.218 32.703 17.302 21.501 28.676 16.751 12.231 42.367 29.377 24.507 33.365 28.808 37.275 39.628 30.769 6.8007 11.554 38.856 57.935 100.13 50.042 6.4031 7.2036 31.708 18.784 31.971 32.329 34.766 40.165 37.072 24.213 27.304 30.998 85.682 72.328 75.597 34.921 33.44 33.399 46.564 35.295 36.397 28.599 30.411 33.698 36.691 31.991 37.876 33.245 40.09 45.614 42.062 39.756 38.882 37.071 8.4261 18.908 48.505 76.358 122.37 86.828 9.8489 17.228 32.317 54.221 33.528 49.167 26.337 25.519 30.617 34.369 31.8 32.286 38.473 39.198 43.348 15.827 23.764 14.335 17.212 57.406 36.232 18.327 30.019 34.157 19.708 24.302 31.142 46.478 33.115 34.595 40.035 49.384 40.754 44.964 5.8737 12.767 30.393 67.481 124.87 50.035 8.9443 7.1785 22.168 35.263 39.6 19.346 36.195 38.344 40.554 22.057 21.731 28.21 78.447 73.935 75.888 33.147 39.074 38.331 33.838 48.985 57.981 30.089 49.699 36.149 21.401 44.49 37.614 43.056 34.863 31.632 49.246 50.205 45.231 52.43 7.3314 23.463 49.048 80.391 137.81 86.145 11.18 9.1002 34.464 65.149 64.677 53.899 41.288 44.201 39.55 27.29 38.115 29.935 49.675 42.409 45.568 10.428 12.59 15.882 13.229 37.6 21.113 10.326 16.916 16.013 15.356 15.843 27.368 20.025 16.994 23.104 14.635 30.206 30.538 34.154 13.398 9.9121 29.034 44.379 108.4 31.073 9.8234 8.3939 15.834 7.7779 9.539 10.118 25.11 29.354 19.556 27.6 29.555 19.406 61.285 71.722 61.383 25.164 25.333 29.517 33.812 21.319 23.184 14.138 16.036 21.587 25.076 22.356 39.56 25.53 21.638 27.554 34.053 30.34 32.554 26.175 10.416 31.765 38.122 53.589 102.87 63.378 14.142 16.37 26.006 41.529 16.693 43.178 26.169 21.01 20.882 28.944 35.103 22.553 72.61 62.237 62.26 15.379 24.875 20.694 28.901 39.414 35.121 24.205 19.745 27.757 17.692 17.788 41.272 48.555 28.078 37.186 44.83 35.588 33.807 36.981 12.59 9.3408 35.224 56.76 117.78 44.287 14.56 9.8611 35.663 27.69 45.964 34.22 32.715 47.738 35.739 34.471 35.267 35.633 79.29 85.95 79.861 34.194 35.334 32.488 39.185 39.054 46.696 32.336 38.234 22.602 24.487 19.504 36.469 53.115 48.822 40.425 54.255 45.332 43.101 48.886 11.853 29.047 57.702 75.809 123.47 70.857 12.748 21.232 37.451 60.117 52.257 63.269 29.743 33.31 25.341 34.547 36.142 40.438 46.327 49.715 43.566 28.182 30.533 23.838 30.012 4.5826 17.125 14.513 39.708 32.049 19.935 22.865 29.203 54.19 27.59 30.786 33.627 17.131 12.722 15.221 8.3964 12.816 41.343 71.965 111.52 48.692 11.314 16.015 43.507 44.403 61.282 44.61 34.394 35.371 39.383 34.835 42.977 40.213 76.665 78.744 73.16 39.335 46.717 46.699 33.963 14.089 35.986 18.937 27.944 35.503 27.419 28.443 55.362 64.244 59.194 21.84 30.863 37.209 28.165 10.747 17.678 22.133 35.098 27.506 19.391 19.647 44.018 47.278 55.839 47.689 35.654 26.509 27.192 29.146 8.9722 30.299 53.282 72.509 128.64 70.967 11.511 15.889 26.613 46.825 51.167 45.177 55.609 39.702 42.09 43.692 39.424 31.189 75.754 77.222 74.377 44.292 42.362 41.382 39.01 18.152 33.238 38.372 31.312 33.992 29.292 24.31 47.935 50.436 36.395 36.505 51.655 38.969 31.458 29.778 11.478 37.306 45.075 77.624 143.1 68.557 25.942 27.557 42.975 55.219 49.204 61.857 32.877 42.707 36.707 33.121 44.3 40.964 61.86 45.998 55.528 29.176 28.421 32.121 37.047 22.125 33.242 19.846 40.89 41.264 27.078 31.119 55.534 53.755 32.994 41.296 38.966 28.455 29.88 28.852 11.769 22.153 47.397 68.88 129.94 57.066 12.166 14.349 45.286 70.149 44.19 50.088 38.337 48.979 54.543 40.583 45.456 46.375 72.922 91.341 70.706 41.21 44.368 45.73 59.233 29.962 45.547 31.873 38.443 29.089 26.933 15.64 43.19 59.693 35.097 52.134 48.411 34.169 35.395 42.579 12.952 33.563 53.512 77.042 133.23 89.424 14.983 22.222 46.459 73.731 49.07 56.839 52.842 44.343 42.724 43.761 50.19 43.546 51.552 47.637 54.357 32.152 24.474 35.274 33.324 12.629 26.735 22.883 35.927 32.002 16.763 23.795 61.869 44.524 35.409 41.955 35.892 27.515 19.122 22.895 9.3408 17.93 46.997 85.245 150.64 59.839 15.953 11.217 37.932 49.257 56.247 53.419 61.691 46.601 48.003 40.181 44.13 40.218 77.845 91.559 74.551 40.162 33.451 45.481 40.872 18.567 28.102 22.724 19.183 36.859 21.968 23.609 46.056 55.832 44.322 36.434 48.449 19.678 26.202 22.297 6.3048 34.011 48.309 89.206 154.02 77.643 15.264 32.487 44.415 45.946 51.829 57.874 55.377 43.699 47.692 45.516 42.267 47.787 52.244 78.034 59.978 30.59 31.82 37.33 36.51 38.144 38.558 23.977 44.409 51.571 37.752 35.57 64.12 61.644 49.82 54.29 68.142 42.865 46.57 46.932 9.1924 25.372 54.454 98.822 154.38 63.361 15.264 15.027 38.031 54.082 66.554 46.241 60.303 56.426 60.684 36.094 37.33 40.065 82.446 89.211 94.987 41.842 58.348 57.031 58.282 45.796 60.488 34.357 50.616 43.314 35.637 26.495 71.495 62.718 56.361 46.512 63.804 54.395 51.54 57.913 12.093 31.898 76.351 106.22 156.6 96.863 21.783 27.447 53.653 66.876 63.361 61.149 61.801 50.446 60.642 49.767 52.913 56.75 32.016 35.72 33.304 14.637 28.386 34.172 28.539 24.156 44.522 11.635 38.93 32.492 36.609 36.973 40.934 41.564 41.871 37.858 42.355 37.462 17.217 20.042 43.968 48.342 55.717 25.105 32.932 32.508 29.253 19.672 39.727 23.476 33.586 45.242 39.294 49.58 62.098 43.107 33.956 48.896 55.599 35.764 30.149 32.314 9.5786 25.11 51.364 94.591 132.54 69.353 13.928 11.011 32.024 50.045 71.11 27.51 52.243 58.932 57.689 31.185 35.207 30.465 75.426 79.723 85.574 50.092 41.584 37.074 44.184 49.158 62.215 32.751 40.46 39.234 50.713 51.227 52.377 61.49 49.283 51.231 60.063 51.574 45.17 45.136 9.3675 37.45 57.177 108.12 149 96.552 14.714 23.032 53.947 71.446 75.02 58.521 56.257 50.805 55.574 31.777 46.341 35.015 42.604 37.518 35.968 18.426 30.257 24.377 28.08 25.661 52.969 17.331 29.297 36.909 39.133 34.22 45.193 55.941 37.873 45.532 66.378 36.121 35.974 48.294 11.091 24.546 46.597 90.573 160.7 63.776 18.439 9.1475 37.565 59.254 87.049 44.418 61.659 61.483 57.384 24.642 31.737 28.25 81.773 91.085 70.553 31.992 44.769 36.613 32.661 47.681 63.522 49.185 26.699 56.829 53.335 56.007 45.308 66.298 32.041 36.48 78.97 48.092 46.063 50.136 18.615 37.289 49.732 100.02 172.49 98.656 15.508 22.845 42.71 60.684 92.424 65.821 60.382 43.47 69.267 26.024 42.039 50.421 47.724 50.442 44.782 26.865 33.083 24.357 30.7 25.005 52.813 25.202 41.782 37.336 44.741 41.204 54.057 68.167 48.328 45.771 67.393 41.452 36.705 29.465 11.402 20.378 37.597 94.959 167.17 56.852 64.85 69.557 62.873 30.166 44.716 37.047 28.244 38.849 52.17 26.891 48.631 62.802 42.311 42.984 60.655 66.543 51.68 42.895 61.736 49.432 43.489 33.025 12.062 23.89 47.313 92.632 151.1 65.856 12.748 17.158 31.105 75.738 74.18 57.029 61.365 67.278 68.753 52.711 42.886 36.369 87.822 95.026 94.038 36.287 52.529 41.14 47.547 52.998 69.186 35.198 59.344 65.032 38.533 45.352 64.053 68.491 66.699 65.617 82.371 52.764 55.02 54.41 14.018 32.856 68.984 99.743 168.02 93.452 19.313 22.957 48.774 85.849 87.673 77.245 76.639 67.811 67.83 45.492 45.445 46.651 47.309 51.078 54.881 23.479 35.76 33.034 27.704 20.087 56.167 12.047 42.847 46.074 36.442 45.861 51.803 60.806 46.782 49.972 60.567 31.232 31.184 33.512 11.478 21.154 47.964 89.077 154 79.157 14.983 20.644 34.39 47.528 68.482 55.888 46.605 52.426 53.517 31.205 36.912 29.308 82.649 87.4 87.274 45.856 42.317 39.294 40.657 50.624 76.31 35.311 52.305 43.364 49.327 36.827 63.619 56.761 37.283 54.571 56.344 50.033 56.108 38.64 14.577 30.578 67.899 100.59 171.33 93.577 61.787 70.74 71.634 27.12 34.663 44.051 38.2 30.216 48.585 26.756 67.542 58.502 49.016 40.549 67.637 68.05 59.383 54.024 82.656 47.924 47.356 49.191 12.247 17.161 47.778 98.829 147.14 81.434 15.652 14.906 36.116 65.847 82.278 51.534 53.837 63.221 66.514 46.22 46.666 36.68 97.455 105.38 108.44 50.836 54.404 52.707 58.269 57.064 73.883 50.387 58.576 51.593 46.467 49.289 73.485 76.539 61.124 71.718 85.497 52.125 60.385 66.507 21.581 38.266 55.94 111.32 171 104.65 16.447 25.794 62.564 68.782 82.202 82.504 61.486 78.952 60.276 46.182 50.085 49.031 9.7618 13.226 13.517 11.023 8.5732 13.509 6.7639 56.84 22.864 16.952 21.037 14.092 25.342 22.28 22.909 11.082 34.805 25.191 20.34 33.98 28.604 29.615 3.5707 8.4705 11.64 33.362 97.846 24.369 3.8079 2.4846 8.9366 18.273 37.778 11.534 21.473 18.847 23.645 19.538 22.611 12.818 24.591 29.44 34.783 14.756 9.3541 16.109 22.405 46.449 21.639 8.1317 14.092 11.526 13.609 17.81 12.633 12.182 29.913 22.159 7.5711 30.817 30.771 29.04 6.6895 15.992 18.453 32.175 101.67 28.708 6.7082 10.235 11.037 2.0519 47.826 6.906 26.899 22.335 27.019 16.163 14.08 18.862 40.66 29.297 25.037 15.322 13.574 13.388 13.295 50.446 28.526 13.652 10.177 12.541 21.401 14.526 19.011 18.916 26.249 16.328 16.921 32.11 29.884 34.449 7.6322 10.062 18.96 36.284 88.492 25.778 8.9443 8.0509 21.135 7.6296 34.763 13.855 25.795 23.971 25.378 23.927 27.175 19.462 47.955 46.262 55.355 20.421 12.981 13.964 18.486 39.579 22.192 15.996 12.649 14.808 8.8769 15.245 16.577 13.394 27.677 19.483 7.5992 30.652 34.324 40.704 9.2871 29.492 32.715 44.037 97.514 43.276 9.0554 20.483 22.693 8.6906 31.142 12.733 30.162 21.039 27.456 26.201 21.29 23.399 29.562 28.832 32.966 10.32 16.852 7.1414 11.258 53.308 30.046 18.524 12.387 14.112 12.578 16.236 18.708 18.601 19.662 24.24 10.242 40.861 36.267 31.932 4.6637 16.666 21.966 49.47 97.729 31.964 7.0711 5.2535 8.7915 12.101 34.741 13.496 29.957 23.667 24.886 22.299 21.915 24.968 47.674 56.478 52.427 11.158 12.319 15.281 18.967 48.885 29.065 16.375 15.095 12.621 14.826 30.556 28.378 21.241 12.329 15.149 18.405 14.16 42.468 27.527 11.71 9.4944 9.3808 19.432 12.53 21.513 15.46 29.038 20.89 9.8726 32.991 29.508 30.713 7.1937 10.897 22.394 40.293 112.46 37.502 11.424 6.753 15.571 5.5778 43.262 20.061 27.842 22.425 29.246 17.139 20.628 27.957 36.719 39.845 40.482 15.443 14.603 13.191 20.922 38.746 19.609 14.642 13.299 6.6009 17.234 7.0427 19.774 16.655 27.633 21.387 12.114 28.475 34.187 29.056 4.272 17.741 25.952 62.813 95.397 41.744 8.6023 14.161 12.05 8.571 28.134 17.881 31.875 17.624 27.648 18.901 17.937 18.672 47.76 48.84 49.896 19.098 16.462 17.176 19.326 46.111 35.415 16.397 25.876 18.323 17.193 12.361 30.203 44.353 29.913 27.298 36.524 33.844 35.59 39.724 6.6708 14.344 30.883 53.484 110.86 41.384 6.0415 10.098 26.032 25.973 35.488 34.313 38.153 29.672 32.052 31.563 44.011 28.205 72.972 80.567 69.963 24.238 29.896 24.031 25.952 46.877 34.735 23.582 18.369 11.508 11.891 11.1 26.51 32.958 24.323 27.166 37.264 37.993 32.781 40.273 5.0498 21.184 48.466 64.85 108.46 64.403 45.486 42.832 38.614 23.701 20.062 16.83 18.398 68.326 40.74 23.741 27.384 27.255 11.705 23.401 25.144 34.508 36.332 37.995 24.196 43.999 39.373 41.319 6.364 12.42 32.175 59.078 106.28 43.763 6.0415 5.1439 18.188 33.474 53.801 30.003 42.807 35.583 36.305 22.902 24.398 24.601 70.254 75.878 73.728 32.195 24.814 25.402 26.566 69.141 54.998 27.895 29.715 28.284 19.875 24.519 35.925 39.444 25.267 31.426 35.541 53.521 59.873 52.928 7.0887 23.638 49.117 61.012 124.97 63.033 10.77 9.2212 25.198 38.5 61.289 34.356 36.513 37.459 41.14 25.367 30.737 28.893 47.546 34.163 39.796 17.628 14.509 12.679 12.629 50.423 30.125 18.415 14.516 15.575 22.53 16.625 33.398 17.199 29.796 26.359 13.45 34.827 31.346 32.632 6.8191 7.5166 27.331 40.308 81.597 37.745 12.166 12.676 20.484 12.822 36.428 7.9171 23.358 25.531 30.916 20.767 22.288 17.863 62.816 62.906 60.31 13.901 18.18 21.178 26.618 42.137 23.452 17.745 9.7468 7.8376 17.012 14.839 19.56 24.633 30.262 23.975 16.354 36.253 25.501 29.494 8.2916 19.17 26.353 43.032 79.58 50.451 12.349 16.159 20.039 15.472 40.351 17.428 24.037 27.303 24.225 22.028 22.825 24.176 60.719 64.802 65.711 26.106 23.948 27.051 22.683 49.104 38.662 30.771 22.634 29.333 20.174 11.091 36.669 33.064 38.956 35.474 35.511 43.638 39.673 41.077 9.4604 16.109 42.866 53.296 117.41 43.223 6.6708 6.2702 26.256 38.93 57.353 26.408 41.268 32.379 37.148 35.637 40.475 40.945 81.202 83.29 83.529 38.177 30.418 37.463 34.187 54.679 32.661 25.522 22.316 25.191 10.334 13.145 36.682 41.864 35.919 31.947 32.51 42.087 40.049 45.75 7.1937 23.189 37.45 61.99 106.35 56.094 13.509 21.902 28.282 38.368 51.76 53.278 40.437 35.56 36.541 30.525 34.106 36.2 27.017 39.933 32.339 22.721 15.676 30.174 24.285 28.5 14.37 18.341 20.213 21.21 25.573 25.698 23.203 23.452 18.553 36.205 26.31 23.189 17.262 17.293 10.21 17.299 20.748 54.374 106.81 48.472 15.572 24.521 24.104 39.74 32.313 29.15 28.329 33.321 26.698 31.725 33.604 26.277 44.264 43.558 52.505 22.836 23.399 25.783 42.597 19.609 14.195 18.885 15.418 10.67 23.605 13.711 15.944 19.142 19.94 15.199 35.352 26.035 19.063 22.879 5.9791 21.639 33.162 51.976 112.51 46.025 22.727 22.275 26.087 41.616 27.889 41.603 20.637 16.107 24.75 18.18 20.451 29.508 37.616 34.48 34.154 12.309 23.383 20.982 18.908 25.343 28.836 9.1036 9.204 16.466 21.703 11.824 34.464 34.788 22.154 26.601 38.686 29.219 29.169 23.721 10.712 24.744 30.541 66.937 108.98 43.828 13.657 18.897 32.391 43.481 24.383 36.926 32.242 43.514 46.371 26.828 33.384 30.078 69.591 63.7 65.098 19.164 29.279 27.272 36.215 27.645 38.321 16.02 17.772 30.859 14.17 12.783 24.319 43.433 30.935 41.924 38.524 28.775 27.025 34.912 11.325 28.853 44.839 91.221 139.15 65.812 20.591 23.944 51.19 38.853 24.055 46.131 39.068 36.466 35.403 30.145 30.224 29.656 31.844 40.189 35.974 11.758 22.028 17.93 24.336 22.82 19.209 7.7055 17.784 23.537 16.168 16.438 19.985 42.821 17.928 24.654 32.323 28.894 25.348 24.567 9.7211 26.763 29.559 66.847 142.72 54.481 15.524 16.139 24.149 22.242 37.963 24.805 36.866 39.866 33.797 22.984 30.875 30.919 48.898 74.749 47.423 23.415 26.782 30.344 27.762 12.865 19.072 11.678 30.81 28.4 24.483 17.748 22.592 31.375 31.362 17.601 25.404 25.983 27.043 18.698 6.8007 34.835 37.583 63.73 129.75 70.199 24.413 23.594 29.351 31.953 35.609 41.357 32.214 41.114 37.167 36.555 35.518 29.526 51.351 65.505 62.306 17.313 26.5 37.769 27.34 34.85 35.071 19.452 33.422 34.397 9.5289 24.896 52.351 57.618 48.396 38.249 36.834 28.621 35.531 28.33 11.651 17.557 38.095 65.159 129.81 46.863 13.21 24.936 45.637 33.155 32.946 39.654 31.449 41.776 45.567 39.972 33.875 45.706 78.556 82.989 71.601 34.187 43.735 33.061 37.56 34.598 37.733 17.653 31.987 36.448 19.504 18.374 45.915 55.299 42.14 40.856 46.193 42.59 32.297 36.586 11.906 28.196 60.98 74.547 121.96 85.165 20.94 23.256 30.674 50.141 38.613 53.521 36.213 37.062 51.549 45.006 39.906 35.828 51.828 48.064 48.997 15.338 28.271 24.51 31.583 49.847 39.147 16.819 34.631 27.798 18.847 15.12 38.158 60.216 36.935 40.915 37.18 49.13 37.24 44.197 10.464 19.326 46.955 90.701 134.88 57.388 13.416 21.794 30.804 37.915 42.872 29.092 38.413 56.068 45.73 38.223 39.68 29.647 79.142 74.279 78.2 31.02 37.862 36.407 39.702 52.7 62.911 41.087 26.838 32.018 14.636 27.925 49.874 49.491 46.26 35.844 43.694 48.959 54.01 54.144 9.5656 35.214 56.58 100.54 133.13 74.485 23.927 22.709 49.154 55.302 45.183 56.494 47.521 47.043 40.539 35.662 38.929 40.837 15.865 14.792 24.989 13.105 19.748 20.767 16.21 6.8739 22.995 9.0898 13.169 22.586 27.17 24.739 16.941 19.468 33.079 21.038 23.929 18.945 17.14 17.091 11.325 21.054 31.93 64.316 111.08 40.993 18.385 12.668 18.992 23.416 40.589 16.818 22.953 34.025 22.727 22.31 13.739 19.422 43.305 48.664 41.646 26.391 25.725 21.442 28.79 38.754 34.989 21.92 19.729 28.258 24.218 17.741 18.722 13.725 12.335 24.576 22.623 25.326 35.395 22.887 21.808 15.146 24.502 31.463 28.618 14.842 12.51 23.441 30.765 68.771 122.79 50.576 19.455 12.58 19.787 25.496 46.008 25.866 30.839 37.816 40.477 23.114 27.308 25.084 64.463 61.59 56.492 16.055 35.986 39.411 36.377 22.638 51.24 21.334 36.385 29.742 31.113 23.723 27.452 32.305 25.187 43.779 42.098 26.795 28.798 42.526 14.891 30.976 47.281 85.279 132.61 88.055 20.1 27.783 35.238 35.141 70.181 45.91 49.123 46.403 40.527 29.043 30.434 26.202 29.999 33.475 19.835 11.225 21.806 17.197 19.157 14.671 28.289 13.987 29.862 26.67 20.169 27.037 37.076 40.022 22.154 26.241 38.185 21.723 28.298 25.905 15.692 22.544 34.191 70.55 165.99 51.636 19.558 15.909 22.485 26.397 50.61 24.14 34.847 40.004 55.652 16.993 24.156 14.597 46.539 57.095 50.611 28.236 42.08 33.264 25.884 18.337 46.211 24.06 34.107 26.987 33.006 30.338 39.403 43.26 28.217 16.236 37.991 30.704 24.4 25.569 15.443 29.419 47.893 69.549 154.89 70.001 13.657 18.886 24.119 49.548 63.486 41.817 53.733 40.66 31.192 27.744 34.735 29.769 56.376 61.376 57.014 21.622 28.745 26.211 24.764 24.485 36.201 24.751 42.84 48.621 21.762 31.458 54.213 62.779 49.82 44.466 52.356 36.238 28.87 36.099 10.851 24.218 47.445 86.566 129.9 59.073 12.042 12.263 33.039 43.248 36.45 30.1 55.525 40.568 43.015 27.244 37.503 30.474 78.03 73.254 91.536 27.982 42.294 34.132 36.135 30.508 50.282 29.528 39.746 40.527 31.327 30.189 46.665 61.673 41.384 35.477 50.243 41.789 44.664 47.247 16.394 34.706 52.259 83.338 154.69 92.963 20.261 16.739 37.546 48.385 60.513 49.504 37.439 56.375 45.455 33.697 43.789 36.377 48.941 51.108 50.548 24.223 28.403 20.31 20.857 25.889 51.505 19.934 31.296 39.337 30.486 32.628 45.416 47.147 47.299 42.874 49.187 50.51 53.6 46.381 15.273 18.927 47.849 84.637 142.41 63.907 10.44 13.519 25.075 47.098 50.757 36.591 43.069 59.581 51.288 23.796 26.424 25.868 75.656 87.052 74.358 33.682 41.107 35.798 37.407 45.984 67.428 27.076 48.612 52.267 35.553 40.195 46.435 55.328 49.319 44.052 67.205 57.561 47.649 64.511 24.439 36.301 68.283 90.374 162.26 95.788 22.472 19.71 39.761 68.328 68.362 62.356 58.914 73.7 62.596 24.485 31.209 32.866 49.987 52.477 40.744 20.736 19.634 19.577 23.843 11.885 29.542 19.413 21.762 27.928 24.323 22.235 51.387 49.289 21.995 30.322 29.165 26.102 20.075 24.46 10.32 20.585 31.992 74.648 125.84 52.82 12.207 18.897 27.997 26.089 45.189 36.486 31.899 31.885 42.855 28.111 29.09 30.039 72.605 56.392 58.424 22.995 37.249 37.236 40.82 24.047 38.665 18.361 30.956 38.868 24.421 26.676 27.792 39.92 30.077 33.1 36.374 31.505 33.599 28.663 17.161 31.824 51.643 68.9 129.64 83.642 20.555 23.838 29.537 44.938 58.075 57.915 47.909 44.265 34.337 29.987 33.96 28.606 53.421 70.215 62.186 24.824 30.426 26.163 32.55 30.875 44.892 18.204 38.554 54.073 22.168 32.119 73.993 59.765 28.164 48.456 49.351 43.729 56.286 40.212 13.048 18.675 56.254 76.227 156.34 69.69 15.652 19.201 30.039 56.466 49.257 30.215 41.001 58.272 48.706 32.947 35.809 30.141 97.437 92.772 82.172 36.753 37.336 39.563 40.143 33.805 52.084 36.389 42.322 48.958 28.007 33.49 57.545 57.067 38.299 45.087 66.878 41.731 41.81 50.446 13.739 27.722 61.555 86.503 147.75 85.716 18.125 26.145 45.666 73.657 60.946 60.595 52.111 65.47 49.599 36.39 40.268 32.228 59.375 58.405 49.85 26.763 35.475 33.155 34.106 12.278 26.476 30.486 34.988 38.706 26.963 25.652 52.249 54.566 43.729 47.537 41.515 24.281 19.314 16.829 7.1414 22.483 31.044 80.379 124.85 58.666 17.029 24.392 41.723 63.084 68.319 63.553 43.263 46.667 47.469 44.286 42.435 44.706 86.938 100.74 103.87 47.542 47.36 45.415 51.473 20.555 41.662 33.292 32.582 33.903 18.708 22.852 50.878 64.379 48.224 52.536 50.045 25.754 24.721 27.451 12.639 26.505 56.069 74.347 141.19 74.051 18.398 34.952 51.764 72.423 65.417 73.559 40.23 44.707 49.349 48.094 44.167 38.671 55.497 62.246 60.521 25.656 42.559 33.027 44.187 19.881 35.475 24.023 36.536 35.962 34.957 24.38 59.736 72.945 42.849 55.962 51.003 36.923 33.677 30.53 12.61 17.051 51.223 81.974 140.41 65.682 70.846 75.086 64.334 28.762 33.068 42.471 38.791 13.528 35.05 19.884 41.29 34.769 20.396 28.096 58.328 55.411 54.246 48.734 45.04 27.059 31.139 29.736 11.147 24.01 54.18 80.864 160.23 64.995 21.471 21.276 47.14 72.45 65.868 43.049 46.014 55.998 54.767 53.132 45.763 51.414 98.949 109.43 88.254 52.024 47.069 47.101 59.245 23.049 48.528 38.424 29.554 31.442 25.729 23.554 55.221 49.699 50.036 55.096 65.748 29.792 29.765 33.375 8.9861 35.135 64.533 87.882 147.56 89.574 17.493 25.323 53.289 79.649 70.12 78.17 42.632 53.194 60.388 40.237 55.547 48.545 67.805 72.655 74.852 31.253 35.798 43.049 42.831 40.134 49.059 22.173 50.78 50.599 26.71 26.956 61.379 77.562 79.768 70.787 53.897 38.423 42.106 52.156 11.424 13.937 42.924 123.63 160.74 68.475 13.21 25.138 59.595 56.797 82.903 57.91 74.344 66.557 64.524 48.952 66.725 65.564 100.29 109.81 113.65 53.486 50.289 50.376 53.54 54.309 62.036 49.806 58.859 56.658 37.164 38.213 76.129 68.069 44.522 71.669 69.838 67.646 62.36 56.733 10.84 36.083 63.846 107.84 167.59 83.873 21.633 40.968 59.015 88.025 88.879 78.969 66.147 65.144 66.857 48.536 58.919 57.139 66.765 63.546 79.501 34.337 38.623 35.648 30.033 14.107 26.632 24.241 46.554 41.732 18.687 39.005 60.6 63.826 58.506 62.206 54.617 24.282 30.99 30.888 10.464 29.912 44.266 83.047 137.69 63.814 17.464 24.415 48.709 69.441 75.325 40.763 49.42 54.943 54.448 51.284 52.804 52.866 97.218 98.848 107.59 39.62 39.032 42.585 43.442 22.305 35.788 27.002 42.947 43.609 27.557 28.869 54.312 43.079 52.52 47.737 64.501 41.916 44.322 32.23 10.712 39.56 70.502 87.165 138.27 95.292 23.77 36.358 47.182 82.058 71.535 69.313 44.236 49.987 44.442 51.288 56.708 46.099 42.636 52.614 42.618 12.052 22.181 21.131 26.476 17.875 10.512 17.752 14.682 18.377 23.971 18.083 23.379 36.932 28.025 23.618 20.765 16.157 13.806 12.737 7.8899 14.748 26.865 55.014 102.36 47.149 16.263 25.059 38.119 41.789 31.067 41.717 17.848 27.168 37.332 27.468 32.458 35.013 69.669 73.764 60.158 27.735 36.854 34.088 31.788 16.148 25.505 27.85 14.358 21.102 14.318 13.55 24.799 23.917 23.711 18.417 29.767 20.849 15.889 21.283 11.705 26.239 41.731 63.936 109.36 60.563 21.92 35.683 41.065 48.539 42.49 51.424 28.377 30.168 27.056 34.205 32.051 35.047 47.266 48.301 44.564 21.372 26.889 28.561 31.973 24.423 30.381 21.694 31.099 27.888 13.885 13.483 41.449 44.075 23.917 28.313 22.805 26.334 21.116 31.406 12.903 24.464 44.755 65.732 133.68 58.557 43.311 61.614 39.652 12.981 28.262 21.96 26.819 28.814 23.141 28.18 24.634 23.67 22.154 16.965 50.082 43.118 30.308 31.868 29.953 27.705 25.229 26.632 11.258 27.686 43.235 71.699 129.92 56.744 17.889 22.908 21.704 39.423 29.122 38.225 40.497 32.131 38.795 38.373 36.507 34.144 60.233 71.146 64.315 25.07 39.338 33.782 41.728 19.538 32.78 24.635 23.364 51.41 62.136 49.715 19.455 31.82 37.034 28.544 42.787 50.423 14.744 28.661 41.395 16.679 18.237 50.67 55.236 33.903 48.458 47.092 38.997 52.899 45.498 11.113 28.766 54.27 81.162 149.08 57.089 10.817 20.005 37.174 38.263 37.37 48.901 43.32 59.262 55.383 35.089 38.085 34.247 87.301 100.34 83.29 37.051 47.389 49.442 42.971 45.108 61.029 32.429 26.897 31.453 18.039 26.332 59.284 59.147 39.588 54.628 57.299 40.828 46.556 47.147 10.759 35.093 59.233 110.51 161.38 92.695 23.717 28.38 45.421 56.816 61.256 63.131 50.039 52.489 48.635 37.279 36.858 38.076 77.712 68.209 66.595 29.266 37.733 39.872 35.655 33.76 39.671 23.38 43.62 35.069 15.013 15.659 51.078 55.669 48.405 44.762 52.812 33.448 34.893 36.902 16.362 17.232 11.117 16.591 9.7211 13.229 10.84 40.488 19.17 18.584 12.598 17.304 30.043 29.594 18.989 19.975 27.521 33.571 12.143 23.039 29.782 23.048 5.172 4.7434 15.898 36.284 95.374 27.579 8.6023 3.9225 7.0834 11.16 4.437 16.769 23.507 22.446 22.816 8.1854 8.1548 11.738 47.78 40.841 48.064 17.421 10.92 25.865 21.645 16.919 15.248 8.2689 11.778 7.4642 18.873 21.052 7.9498 8.1363 16.285 12.791 15.068 19.398 21.739 21.79 7.5166 12.659 38.115 41.325 100.94 48.999 4.9497 6.6681 15.366 46.825 48.924 47.274 25.334 26.76 23.67 13.019 11.769 12.763 33.556 32.496 22.683 11.906 11.533 8.1086 14.37 47.231 21.749 12.425 13.229 13.748 17.956 15.543 18.237 20.376 20.154 17.641 7.4472 25.02 28.992 29.073 7.3824 9.7724 30.096 52.101 99.058 33.587 29.202 29.855 31.788 11.269 16.778 6.8374 13.601 39.607 27.852 16.42 12.218 13.137 20.154 17.748 15.563 17.263 19.682 23.065 17.371 38.453 32.259 27.487 7.1937 16.394 22.776 59.395 101.01 32.508 12.51 4.2041 12.534 4.2598 8.6915 10.261 26.421 27.703 25.29 12.99 11.747 7.0218 66.532 61.24 60.347 20.341 17.19 29.958 24.094 29.862 28.018 17.625 11.582 16.699 18.542 12.239 20.707 19.642 12.091 19.38 17.498 30.845 32.606 29.962 13.874 21.5 46.597 61.927 119.25 66.923 11.402 15.544 18.216 43.372 40.679 44.254 30.872 18.934 22.548 13.739 13.946 13.926 35.924 24.163 25.962 12.298 11.937 12.339 15.411 36.29 15.898 12.654 8.1591 7.7919 10.844 8.2946 17.035 12.791 23.414 27.39 7.3023 30.422 31.588 32.879 9.4736 11.236 30.59 51.037 110.42 33.82 7.0711 8.7277 7.8257 13.299 22.053 9.8313 27.97 25.749 27.984 6.4031 20.537 11.452 52.335 59.525 65.423 16.718 15.788 28.588 27.322 24.3 17.875 17.216 9.7248 14.177 16.547 23.85 9.3059 16.407 12.946 19.478 15.79 26.704 28.51 20.397 12.319 20.482 42.524 55.635 122.81 66.063 9.434 8.2439 18.854 37.459 36.884 42.32 25.966 20.598 27.941 8.0623 18.405 11.766 56.793 53.94 52.321 11.8 26.655 13.36 12.933 46.96 27.951 17.759 12.801 21.607 9.1104 11.67 31.997 27.839 32.178 27.335 28.619 37.195 40.645 41.794 7.5166 12.718 35.913 51.829 102.23 49.087 9.2195 9.8031 27.46 33.336 16.992 28.126 28.304 25.008 24.336 28.275 19.274 24.402 85.975 83.289 80.697 32.031 32.55 34.384 24.769 31.67 30.15 31.932 20.87 21.394 20.63 22.064 29.661 31.324 18.601 22.113 38.999 39.586 36.942 43.15 11.113 28.134 51.858 69.192 125.29 77.609 9.4868 18.799 32.55 57.615 30.197 50.64 28.164 24.617 26.259 21.737 30.112 18.309 52.785 42.385 42.66 19.085 20.946 13.134 16.279 53.742 48.13 18.692 26.737 24.113 16.407 9.1104 33.607 35.471 24.771 23.216 26.705 42.692 42.724 45.765 9.5917 7.2457 25.15 75.619 120.8 44.688 6.5192 1.6569 18.858 24.289 39.587 30.16 30.149 35.703 37.29 14.883 14.396 14.225 69.521 79.25 73.667 34.42 32.631 35.746 26.481 47.786 50.747 30.494 30.993 27.41 26.374 26.45 28.716 35.128 21.596 21.213 36.017 43.797 43.601 43.951 14.942 27.023 45.809 66.616 137.17 79.189 13.73 15.769 26.695 38.803 45.806 46.516 36.546 27.371 38.85 23.404 20.056 21.523 47.507 36.971 40.038 8.6891 17.393 14.714 8.0467 32.168 23.543 20.503 10.226 7.4833 25.612 21.109 20.761 28.775 21.014 24.454 13.894 29.845 25.215 34.492 7.746 14.586 28.662 45.918 92.338 27.031 6.0415 14.386 15.102 14.982 5.0809 8.0752 21.093 24.013 21.504 16.179 12.5 16.913 63.896 73.754 65.893 24.269 22.699 28.302 25.928 20.211 24.073 15.56 17.96 5.2644 20.736 16.395 20.07 18.698 17.877 16.864 25.717 26.64 27.513 28.443 13.332 24.14 42.67 53.856 97.903 75.481 69.458 69.812 66.867 27.902 21.972 20.205 18.695 44.679 39.083 17.317 14.462 17.948 11.95 17.47 51.241 33.991 26.81 34.762 33.259 35.574 37.405 41.824 7.5166 11.683 39.611 61.976 119.58 49.715 7.6158 7.0428 37.027 35.605 44.852 30.913 37.469 34.052 36.004 24.824 28.067 28.769 88.889 87.951 75.898 36.776 33.2 40.863 35.669 32.97 36.404 30.998 25.211 30.419 14.608 14.785 41.658 40.443 29.88 28.45 40.356 43.829 39.022 41.862 10.782 22.633 55.841 90.227 129.15 83.214 14.577 17.541 39.755 46.837 40.184 62.631 34.59 33.571 34.043 26.134 32.473 27.355 43.677 50.671 48.007 24.094 32.917 32.757 33.782 11.169 11.63 14.401 21.676 21.906 27.593 25.904 31.132 39.651 32.668 27.767 32.666 20.181 10.452 12.155 5.7228 22.17 40.342 71.962 130.3 54.293 12.806 18.218 46.585 65.873 50.593 48.334 26.141 42.65 41.041 27.464 37.49 33.917 70.208 71.03 83.424 32.722 29.875 41.076 30.655 14.748 22.929 40.31 25.464 32.846 24.273 21.652 28.559 39.054 31.67 28.277 38.907 19.49 11.729 17.425 11.948 21.794 49.832 86.888 135.13 87.237 14.916 23.674 57.8 61.345 72.913 65.766 35.636 26.976 29.21 28.182 31.157 33.959 29.136 39.75568 33.98455 47.80412 55.81559 55.99189 78.30599 41.066 47.9072 39.87996 57.97196 74.82128 55.83234 68.60185 12.09508 33.70208 26.11277 25.80335 58.02875 41.98888 43.66763 33.428 42.00793 56.74762 41.93285 61.36435 48.32392 77.76668 12.31117 32.33717 25.224 25.5 31.28098 20.68212 32.76431 20.70024 20.46949 10.54751 14.29161 36.445 31.12876 21.9488 31.38869 32.91656 38.24918 24.60691 15.02498 30.7 20.67607 32.34579 23.04344 39.70831 24.46937 38.17394 11.45644 5.567764 9.137833 11.78983 18.77498 13.38843 11.69402 25.64664 30.42203 20.90454 21.36001 22.028 27.38156 31.45234 29.31723 22.78706 30.26549 26.66458 16.07794 14.20387 12.45994 8.860023 15.94522 16.52271 10.24695 26.99074 16.77796 16.46208 18.73499 27.90609 30.307 40.71241 42.12481 17.07337 25.90849 37.98026 43.00872 49.11975 50.08493 49.5757 49.747 45.82848 34.82815 43.77499 47.32336 38.35036 46.21147 31.35283 30.51639 34.83533 36.54449 31.48809 47.34184 32.29164 36.10055 12.14496 23.73289 21.78876 25.27845 17.78 15.17811 20.25154 19.80215 24.13763 22.84458 22.08789 14.55593 17.49643 21.69965 14.36576 26.40786 22.00852 26.801 29.3087 24.43066 30.22771 38.12761 43.41823 35.47031 30.65476 18.59723 16.12009 11.26943 21.37087 22.78784 18.58955 31.362 27.45906 36.04759 33.07783 45.06028 26.4845 44.00325 15.08074 11.24405 13.94889 11.86231 13.89758 13.43769 14.62386 34.537 34.81092 34.09105 36.16075 35.64828 33.89985 39.72657 35.03427 23.04344 18.14387 28.56221 25.687 29.93326 25.39291 46.80598 28.14249 32.28622 28.62516 31.60696 18.9842 18.47701 12.89961 10.75174 19.54994 24.23634 14.89966 40.983 42.9907 44.39369 45.51264 49.00612 34.58902 51.0294 22.71563 24.11224 23.3538 20.94755 35.02856 30.19934 23.68122 27.43356 11.54123 24.44995 27.21764 30.02332 38.00526 25.76 39.07685 40.78725 39.19694 47.46156 47.59202 51.11556 15.30359 20.22869 16.57106 16.98823 29.09295 24.24459 25.72547 39.59293 31.645 40.66694 28.59021 38.6523 52.19387 29.83287 53.33854 33.79053 29.7859 31.2346 33.01515 38.22303 38.04208 32.39136 30.10316 23.20776 29.40408 19.04206 26.40076 35.79385 22.33383 23.71919 16.65533 28.157 21.54994 29.35984 26.49906 53.1921 26.22594 48.20788 31.08376 27.48818 32.47461 25.19127 27.38978 26.67583 27.21029 29.75567 17.23949 21.49884 19.07878 27.12563 33.40359 15.60769 19.08926 12.51399 35.04568 27.08874 14.69694 44.00909 35.16248 48.24521 43.78356 47.41097 35.98889 35.628 42.1603 37.30267 48.5305 48.02745 48.05575 61.77785 23.84511 16.10311 15.0246 18.27231 29.28732 29.7255 13.40159 22.13662 26.18435 35.36415 25.356 41.53355 35.23118 27.93286 47.3615 32.35092 45.61885 31.0608 33.52794 38.5718 33.43249 37.88795 45.22398 39.20075 39.52075 23.60021 23.00364 25.49575 34.43875 40.56654 21.21092 22.01946 26.53827 38.86881 46.35282 29.34 23.51525 30.12917 27.88569 31.98894 29.70875 46.11645 37.28665 37.95161 34.33264 36.37462 38.19984 41.94378 43.16065 38.78465 23.80071 25.62863 24.39501 22.91334 15.417 30.12171 41.45338 43.89624 39.12017 32.6751 35.41749 37.92087 33.93566 35.41822 31.69765 37.58302 44.2363 38.08958 38.92475 21.05149 24.95791 24.79171 29.70569 47.77445 14.91349 26.01881 29.57584 28.40917 46.88289 23.63492 32.69726 14.23104 9.083 7.905694 8.455767 19.38427 9.836158 10.95445 13.91941 3.674235 6.062178 8.746428 4.898979 4.743416 7.314369 6.763875 7.905694 8.031189 17.299 17.74824 18.35756 23.05971 17.64228 20.98809 18.10387 8.616844 11.64045 14.04457 6.363961 11.36882 6.576473 13.32291 11.55422 17.07337 22.16416 15.58846 22.81447 20.71835 16.50757 25.36237 32.596 41.94341 61.15145 48.64412 62.95832 58.67921 54.24712 17.39253 26.14383 22.52776 25.85537 24.34132 33.48507 24.69312 36.30083 24.75379 36.75595 28.39454 45.63989 47.91138 29.72793 46.44351 37.66298 58.66643 46.38426 30.93542 78.31 89.8916 87.95595 100.5709 98.99747 89.03511 103.8184 31.94918 34.35841 42.20486 44.09649 46.9867 60.62384 50.2643 58.30738 54.14333 56.56191 58.89185 75.14153 85.98546 52.12725 66.79072 63.23962 79.15017 136.13 137.3617 140.0955 169.4358 164.3426 145.3909 158.6742 88.24115 101.0371 106.5692 112.8926 112.0658 119.3514 103.8027 114.2399 107.0852 106.3062 142.3561 122.6683 54.084 67.6333 64.57061 66.46992 63.01832 67.30997 75.96921 26.64298 33.41574 36.00599 32.38226 42.51306 48.38994 40.72832 47.72194 37.19161 41.24802 59.83521 56.88368 63.48284 36.47512 61.19042 71.53507 60.76649 61.68015 63.92056 56.35162 52.45549 77.74874 69.36353 66.51686 69.70825 40.13799 52.09537 63.99958 48.40523 65.14261 11.511 13.28533 9.617692 15.44345 12.36932 17.26268 18.17966 11.31371 8.246211 7.28011 4.743416 10.77033 7.615773 9.486833 7.516648 14.1598 17.08801 13.72953 17.90251 7.3751 15.47702 10.2868 13.88612 17.26176 15.15982 10.2868 1.293926 8.922065 9.100233 9.100233 10.5606 7.738814 12.0991 9.409051 13.82169 26.0036 26.21155 22.68191 16.56711 12.66757 8.148021 13.82419 22.40949 14.32656 15.66273 14.40105 22.23835 25.58822 25.82306 24.45347 30.407 33.85927 43.85127 35.32928 31.66983 35.13406 29.53408 12.47293 10.13539 6.261793 10.27512 29.31467 15.75062 14.21696 26.85022 29.46914 27.48531 44.07251 38.21573 31.31054 23.25636 23.16182 21.69152 49.299 57.75296 61.75636 60.24563 46.66633 60.34461 58.69228 5.735337 7.131626 5.228584 4.390227 24.14212 28.46089 9.469957 43.91512 32.66123 37.76925 23.64534 44.32613 39.90093 24.29774 27.93038 22.99544 50.39437 44.11449 25.84105 43.69771 78.16877 78.538 76.52302 81.35006 54.73486 67.27242 46.33555 70.76712 30.16743 38.59784 42.90291 41.3179 49.00278 52.04892 37.82221 48.73625 24.54569 24.45023 26.29194 38.0516 39.53553 37.87195 34.57242 46.20169 29.91583 47.25715 29.66292 57.34208 71.95751 59.72046 61.16524 67.41699 67.77896 52.566 48.4195 41.84372 50.2883 54.23248 48.17582 51.42806 18.91133 7.550838 5.77893 8.516254 28.56676 22.35988 3.492342 23.68061 41.878 33.82512 32.424 30.38986 38.577 43.53047 64.9751 54.00488 51.16382 49.44008 59.7976 28.63986 25.82049 24.60092 23.90655 27.168 38.0577 17.00947 27.48774 20.35091 26.10068 36.07699 35.49074 38.65183 28.21581 35.79145 43.87927 52.22269 36.80451 36.78522 40.87817 34.07726 47.77666 43.25142 61.31247 46.77165 24.35322 40.71889 22.91685 33.43361 47.61664 42.496 41.91181 55.99385 49.56294 58.77224 44.78362 57.37753 21.84316 23.34741 29.28081 21.25215 26.71213 35.0426 24.64825 27.13791 20.80084 21.84892 31.95137 40.3842 40.44815 25.98114 34.42281 39.94131 45.62082 46.14046 33.75297 51.83827 43.63663 42.73797 44.05777 53.02194 44.81442 36.91942 30.35818 42.62011 48.42627 41.37746 42.77 50.89533 57.28411 46.07094 53.57681 52.95893 58.47796 21.64546 27.67908 28.79754 21.30214 25.00884 34.10649 22.04209 33.20138 22.38383 27.77382 33.83302 41.92292 45.88364 29.68504 22.119 21.41261 24.74874 15.37043 30.3768 24.25902 32.64583 11.24722 17.30607 14.33527 14.05347 23.22714 20.0624 18.5809 20.05617 22.10769 25.67586 20.98809 33.5 24.749 30.68795 26.1247 23.39872 22.15852 36.17665 36.23534 11.42366 18.20714 11.86381 15.41914 21.58703 20.25463 18.43231 27.15695 28.59196 33.85631 29.81191 32.47691 26.41023 16.36307 16.27882 19.67232 36.11786 17.845 22.66642 20.97805 18.68532 28.06151 21.60937 24.6935 10.02365 16.93811 17.08405 12.93601 26.52758 16.90005 13.61447 22.89159 21.8886 24.52128 24.14775 30.19042 30.71595 14.93447 21.65697 19.09516 27.01575 19.48307 18.63947 27.28109 41.39072 46.17266 32.03258 39.75077 41.27616 20.68094 58.433 75.9312 81.03283 61.94338 83.88925 86.57528 97.6052 28.76874 54.54962 52.10211 36.35506 71.5431 70.24705 69.51551 76.25096 45.39535 51.54902 62.1322 82.53225 81.30782 45.46068 56.03475 40.80394 83.58831 79.55051 64.45454 103.5857 91.35691 88.42272 92.23652 121.1207 96.43884 69.41598 79.95182 57.85938 75.66109 98.18024 65.816 77.12232 79.24033 74.15441 107.4359 81.77402 105.4306 44.07782 51.6596 57.44148 30.80047 76.00037 66.95171 66.76633 91.48774 58.37505 63.44901 59.81655 86.32927 73.29949 49.72029 61.24794 57.92892 78.25342 76.97434 65.35423 86.75964 92.10485 110.1007 99.76378 75.956 82.43009 81.15555 64.89135 97.08221 89.1389 101.5367 43.73129 53.17059 51.62682 42.61983 73.79085 68.25722 54.65431 85.79803 47.45659 65.63699 51.0235 68.73408 74.87176 52.63331 71.27339 48.75421 76.22479 82.24884 46.837 43.72928 32.95072 52.5 47.91138 50.47276 41.02743 8.573214 19.9875 16.76305 12.05197 21.50581 38.29164 12.74755 32.17919 30.15792 25.10976 19.38427 26.27261 35.34827 29.46608 21.80023 27.38156 34.44198 35.22073 30.33562 44.79118 37.24916 57.38467 34.63 44.07664 43.061 32.21025 42.45292 38.8748 50.60632 8.674676 17.61391 12.8355 12.29837 19.24838 21.38925 14.93318 32.69557 22.6495 26.89796 23.07596 30.4795 28.42974 23.83275 27.59076 36.15937 35.15324 38.177 45.92113 38.06902 39 53.72616 45.63442 49.94247 15.31339 17.13184 15.50806 14.5688 21.03568 22.39978 19.68502 25.22895 34.94639 26.55184 32.05464 42.12778 42.77558 27.42718 29.23611 28.53945 45.73565 38.46752 41.629 32.93554 37.74917 41.11265 42.24334 39.17908 46.65297 10.54751 18.22773 19.58954 17.53568 27.80288 16.48484 13.38843 28.41654 23.16247 25.91332 31.70173 32.76431 38.52921 27.57263 24.87469 20.93442 56.655 40.46295 37.74917 39.29058 52.04565 45.8939 52.82518 36.12132 38.94868 46.68779 44.42691 49.37104 53.64233 35.57387 51.99519 18.29617 31.21298 22.14159 26.86541 38.78466 25.23391 25.10976 62.964 48.17157 51.46358 60.04373 65.23228 55.72253 64.98846 26.19637 28.08024 37.60984 30.74492 31.08858 52.99764 31.00403 32.41142 8.645808 33.68605 19.01315 29.31297 40.88704 43.93177 36.23879 23.294 35.51232 34.6356 41.81357 43.10887 32.64008 49.65254 9.791578 16.29033 15.60849 15.34194 32.04099 29.31083 15.71226 29.47244 14.58167 17.37455 19.27109 26.18444 25.07738 36.483 32.02454 32.90462 41.58983 45.83199 28.7253 42.44829 19.97498 23.31768 18.49324 15.74802 20.733 22.50079 14.71637 19.90334 18.7959 26.45481 17.39458 22.92846 30.80121 21.12548 19.30581 22.74078 24.00893 32.13587 24.75595 28.76754 36.633 39.50768 34.4176 31.58435 52.26854 30.65942 46.19215 13.73733 9.978548 8.693183 13.83061 12.56412 24.13948 8.99206 21.49419 18.14229 10.55597 6.77179 25.53149 30.89383 38.626 32.48692 49.49545 37.79153 36.57048 41.17524 32.87856 26.35906 20.94278 12.51399 19.86957 16.31564 21.19434 22.63184 14.41527 20.95233 14.63557 16.79286 15.60769 25.97306 27.64778 32.37 39.24793 34.03234 39.40051 52.16512 45.00222 37.11334 22.08619 17.42412 9.338094 15.60769 12.08305 16.16168 22.78157 9.327379 14.40139 11.89117 12.09959 10.31504 20.63977 20.86624 18.97367 29.55334 16.77498 25.45584 22.81228 18.68689 26.45373 32.438 49.94797 54.92176 53.09426 45.54558 39.78945 65.18435 15.34927 18.85736 20.50853 27.9249 31.18333 27.62245 23.24651 36.06383 13.31165 32.83291 16.5106 38.704 46.15626 33.811 36.82391 58.36437 52.1977 63.59245 36.96214 58.75032 14.46375 19.59081 22.37856 13.28909 24.90381 31.01935 20.17424 35.60618 12.28007 26.43483 20.63977 39.48417 38.37447 25.11971 36.15799 47.10414 30.16621 51.78031 28.69495 50.29513 52.36411 44.07494 40.91455 65.45533 59.96499 34.01176 32.60368 21.94083 24.09149 43.82921 33.296 32.56378 30.00333 42.93716 53.73639 38.08937 52.62509 28.10694 26.16486 21.48953 31.08697 32.47461 31.40701 31.1705 37.83649 25.10378 18.96312 19.95495 36.53491 38.49935 15.70987 19.15202 18.01111 28.01785 34.17894 26.69457 32.97272 35.27889 58.27349 38.69884 59.97666 44.08174 28.59021 21.00476 22.39196 32.95148 47.68438 25.819 33.56188 41.2068 28.35489 50.27723 35.98611 60.3904 28.17801 24.84754 29.91989 28.33725 22.3875 34.33948 29.90318 30.9645 20.68816 26.37802 25.11573 41.15823 31.73326 12.56185 54.518 43.43376 61.60191 51.94845 63.19307 52.18581 67.4797 10.78482 8.117183 11.80918 8.833911 22.39352 24.89772 17.12228 34.54047 15.68574 30.29226 45.3612 46.28543 44.75554 33.68851 28.615 44.06649 52.78231 41.55092 46.37686 35.86904 59.5278 35.12023 33.69885 35.99173 32.61607 40.12572 51.35296 37.90296 41.99455 19.04072 32.72838 25.95774 30.53617 54.62118 32.48625 39.07797 22.81708 48.90226 48.56546 34.25182 33.063 39.57478 48.10015 27.96445 54.60203 47.61343 52.66351 33.02433 33.59707 39.64396 29.90756 42.66624 55.26001 42.4041 41.48106 18.44696 32.09817 23.85133 34.80454 45.32436 19.58391 21.41055 24.17664 30.60695 46.28738 40.098 48.15596 54.05938 59.28063 52.39668 47.13496 46.68427 32.18632 32.29646 36.55753 33.15855 44.15136 46.00231 32.96129 40.58927 17.68585 39.27147 24.18708 36.86707 55.43185 23.02099 22.77551 23.90693 35.53554 51.00785 16.658 10.33199 16.83746 12.55986 10.70047 12.34909 16.03122 4.66369 5.634714 9.565563 4.242641 7.331439 8.732125 7.889867 7.53326 7.228416 9.874209 9.460444 10.87428 11.74734 8.336666 13.93736 15.87451 15.05822 10.46422 14.47411 20.43893 11.42366 12.15525 11.29159 14.55163 13.55544 23.775 27.97767 27.70379 35.45772 35.90961 32.21025 36.06591 5.612486 19.94367 13.08625 17.67767 15.37043 17.35655 18.25514 19.09843 33.84154 32.61518 21.31901 26.9583 27.04626 22.26544 30.55323 27.32215 36.07284 34.97856 27.89713 37.86819 30.08322 32.48846 23.52658 48.049 60.1789 57.94394 59.88739 65.22653 74.77633 70.94012 22.61637 22.33831 25.91332 29.78255 40.9695 56.87047 32.32646 49.88487 27.69476 53.60504 43.75786 49.35585 52.90085 33.70089 49.22906 50.36616 60.73302 73.59687 85.14 97.8647 95.82145 109.3892 102.4536 87.28545 103.4444 40.68169 41.85093 45.57686 39.06725 64.06052 68.23672 44.89432 66.11165 55.05225 68.30447 80.04061 86.21195 90.63802 63.26531 85.54239 78.21445 97.24711 106.7872 73.96283 88.67497 87.52999 97.09531 97.40893 147.68 147.7786 166.5998 177.721 176.7979 154.1923 185.0925 97.56664 87.09908 108.1215 96.29512 109.5981 112.651 99.04671 110.8873 122.7284 123.5121 148.1604 140.7427 134.4489 130.0875 137.6408 145.8749 153.4837 157.1743 80.683 93.20294 95.75204 100.7771 103.5828 92.82765 114.9368 34.65083 41.81893 53.88183 36.45416 50.14377 68.1743 49.03585 60.12703 61.35043 68.84244 59.82082 78.37868 85.20943 66.49386 69.80894 9.9247 13.58308 17.10263 16.27882 12.74755 14.86607 16.86713 5.700877 13.15295 7.648529 10.63015 12.16553 7.071068 12.74755 13 24.78911 19.03943 28.50439 22.82542 17.02939 19.14419 23.71708 16.32483 21.09502 23.02173 24.18677 14.31782 21.93171 25.26856 18.78829 23.02173 23.71708 15.228 19.02354 23.29101 21.27638 20.15565 26.73483 16.10994 4.731833 16.10994 11.85163 6.554559 16.56467 11.18491 16.61199 20.37232 32.25646 26.1624 18.30607 27.4247 27.31643 20.82513 23.94421 11.97169 27.54931 19.72403 26.64386 25.65504 20.11858 39.928 43.17372 48.40477 46.40438 41.53473 39.58593 48.35587 15.38629 19.83225 15.80791 12.48543 35.76633 29.65323 16.56013 35.7974 29.32081 38.6953 38.54117 49.56767 68.029 94.98304 66.75265 59.49637 72.82761 70.94395 72.27347 11.26189 6.236513 26.93812 10.43686 37.65974 44.38516 10.39664 51.10998 42.92494 37.72084 32.84363 50.59613 71.34428 34.78123 46.14677 79.178 73.99142 89.56537 87.87041 99.79002 73.28635 87.00126 32.96876 44.16483 34.4591 32.57261 46.38246 55.299 34.75429 58.73104 38.77103 34.22306 36.78964 29.27903 48.54059 50.24512 45.97103 55.42412 63.65408 72.954 70.83605 75.77371 85.18445 64.75849 66.53489 84.83685 11.61501 10.95883 23.06102 20.33318 36.72741 33.50389 20.22631 42.75721 37.449 36.41444 40.94518 56.11752 42.428 60.03597 53.06528 65.6479 59.14535 37.47514 67.85203 35.26464 23.80807 27.20027 24.26052 32.08737 38.43941 25.21126 30.54505 22.63183 28.02459 26.2872 34.93868 48.496 51.51591 57.83976 47.19153 60.34054 49.93546 60.84268 28.0176 21.89322 19.75981 23.62955 30.08597 36.68516 26.09191 31.82735 20.11383 30.72752 34.83324 29.25671 57.08976 30.08294 41.31217 54.14 53.40604 46.13002 62.01177 53.78968 51.64714 54.47643 29.10672 22.09043 23.07083 23.60879 29.76152 30.3755 20.28 31.35945 22.7244 22.69462 39.90384 27.51362 40.01311 29.45684 27.77101 35.79017 41.34391 46.36474 35.50261 48.46416 27.55285 41.67373 37.92269 61.54413 46.76105 22.68557 29.70695 36.61825 44.41414 43.14444 18.2 26.73481 22.95648 35.80154 28.44732 25.89401 28.33284 5.809475 10.27132 15.32155 13.05756 23.90607 20.83867 13.90144 29.03016 18.56071 23.08138 22.46664 28.6007 28.67054 13.70219 24.44381 21.45926 27.95979 35.50352 22.62189 31.64253 31.54362 33.39536 36.08324 40.74923 31.99609 22.17544 19.42292 23.67488 31.13679 29.97082 26.618 33.98897 30.11229 32.1014 33.31666 30.83018 45.48077 12.02082 15.41914 14.94992 11.82159 20.56696 19.24838 17.53568 18.80824 24.4387 20.95233 27.96873 30.69202 28.68362 20.97022 25.795 33.2934 21.40087 35.80205 30.31716 28.57745 33.75606 8.322346 12.51285 14.75296 14.40318 25.70739 27.27283 19.69282 29.78579 25.29611 25.03795 24.94678 30.72467 24.20451 Date+BioMarker Correction 62.196 57.545 56.108 21.249 31.068 28.684 33.35 16.748 21.668 15.886 24.574 23.54 22.83 25.365 29.688 41.893 28.534 33.269 38.418 22.671 21.72 18.859 9.0692 25.763 56.016 85.308 111.83 47.464 10.296 14.693 47.708 50.457 48.763 38.718 36.646 44.969 44.785 28.618 33.264 30.744 74.407 86.34 84.169 30.174 31.777 43.974 41.164 16.086 24.3 22.724 17.234 26.243 22.825 25.42 40.826 40.252 36.962 22.694 52.672 26.964 38.717 27.668 8.8318 32.772 48.088 97.261 127.16 77.791 15.811 18.682 49.047 62.324 47.369 56.097 26.299 30.91 32.129 26.22 30.52 35.208 53.322 42.312 50.548 29.013 25.485 33.649 23.859 25.681 24.93 20.937 33.901 35.141 23.753 20.075 36.669 40.733 38.575 34.191 35.417 29.708 35.447 22.774 8.4853 21.506 39.278 70.647 131.18 64.304 17.889 21.276 35.238 37.856 43.963 44.689 28.059 42.928 39.969 28.102 40.762 40.783 87.783 85.791 81.143 41.967 33.17 39.771 36.27 26.594 36.503 20.252 26.476 34.042 22.231 15.531 45.131 49.311 40.586 35.634 47.964 35.037 37.311 37.803 12.062 23.911 61.681 77.978 140.56 79.076 19.455 24.582 45.169 58.552 55.563 59.695 43.432 38.925 42.577 26.215 35.749 26.974 49.326 61.81 47.068 30.68 23.399 38.798 28.009 10.173 22.842 16.504 30.414 40.137 15.186 27.644 42.452 41.214 33.184 39.575 45.221 24.679 22.131 27.877 8.231 19.164 37.58 75.09 158.71 67.31 8.6023 19.551 43.009 45.25 50.908 38.154 35.06 43.961 41.08 31.121 36.517 40.74 71.231 77.623 85.172 35.064 38.341 50.963 43.761 19.962 25.249 39.964 25.017 32.479 18.958 20.562 46.797 46.197 30.216 25.884 46.269 28.347 25.168 29.688 8.86 24.393 64.432 81.788 143.66 71.42 19.558 31.422 56.31 71.014 42.706 76.486 47.481 41.255 37.738 27.749 40.441 34.323 60.571 58.501 67.396 29.975 33.731 35.728 35.267 43.595 45.577 18.951 41.005 40.05 30.166 25.338 63.927 54.807 55.613 53.69 38.431 45.801 47.182 44.506 8.5732 23.78 56.103 101.21 143.84 71.754 13.038 20.782 14.0096 34.19175 27.94858 57.9613 44.46611 20.51818 40.04357 36.33323 54.51511 50.50104 47.94879 57.23485 53.81419 60.50669 63.14598 72.30952 65.76327 29.49698 32.49851 42.69933 59.34713 71.70911 43.3154 42.22283 60.96123 49.26492 17.46408 43.71416 30.87702 66.79641 49.21984 46.54577 61.1083 63.17527 29.9773 28.03243 37.16035 34.45346 36.66629 59.17629 31.81025 34.97856 30.79973 62.94258 47.14706 21.39873 32.26441 22.79815 50.94836 19.9875 15.69235 20.5061 21.24265 22.52776 18.70829 12.75735 21.19552 12.5499 27.16155 31.68201 15.34601 19.67867 21.01785 18.41874 18.19341 29.52118 25.26361 19.352 13.55544 11.97915 15.3948 19.9374 15.42725 23.58495 16.95582 17.97915 12.93252 16.36307 29.40663 21.04163 19.60867 19.30673 25.03498 25.99519 18.20714 20.65793 24.58658 30.95561 35.55981 30.53277 29.47032 19.30673 30.3521 24.80423 22.99456 24.11431 22.41651 28.74891 19.42936 21.1542 16.92631 21.22499 15.54027 26.63175 24.31049 20.04994 20.42058 43.57178 37.66962 34.28557 35.83643 36.18011 19.17681 22.74313 21.58124 33.20015 30.80584 43.7207 50.38601 53.30572 47.42626 52.6925 24.18677 29.858 27.20754 23.18405 44.07947 13.7659 8.558621 13.55544 27.40894 42.37334 9.460444 42.1693 20.3224 13.68393 26.05283 29.48729 37.65302 35.53519 27.72183 14.46548 20.63977 22.28228 40.06869 28.04461 17.288 27.58849 9.212763 12.61448 6.846532 10.68293 18.82485 15.2848 13.01442 7.424621 22.35229 14.92062 11.66726 20.76957 17.72357 19.52882 25.65395 24.20485 29.34493 15.33379 15.17811 14.00446 22.83364 26.63879 19.2836 15.82945 18.52026 16.73747 17.90052 24.28403 15.82945 18.30301 18.77308 27.59658 18.70447 17.86057 34.62245 19.89616 36.84717 32.39047 37.10988 34.13628 18.44683 12.13025 19.17588 27.67929 29.64312 20.0713 9.486833 15.39016 19.38704 30.11881 31.35966 19.48992 10.92834 16.75027 26.15339 29.04184 17.05453 23.26248 16.8226 17.58977 22.54773 14.45683 34.4093 16.88787 15.32971 13.76953 11.98332 28.26659 21.89064 14.19155 17.69746 17.52142 23.02607 29.80268 27.24335 23.2379 15.96246 10.63015 10.0995 10.16858 25.26262 21.0808 19.71801 18.15489 32.54228 21.42429 20.46949 19.59592 22.58761 27.07028 10 26.8961 39.32429 43.42119 51.14294 40.68906 38.17591 35.19943 35.44573 44.70123 50.22748 51.47232 17.34359 32.02187 27.21029 45.00222 49.21788 26.4764 33.03029 26.27166 33.3976 35.92771 17.96664 19.29767 15.06652 38.93071 44.02954 24.71841 47.51842 45.09545 54.44079 62.30088 53.12438 55.40217 24.86363 39.97749 42.40519 54.90173 51.99615 37.8329 46.23177 43.65464 51.02163 61.35953 22.33977 38.15995 34.80526 60.7739 31.99438 67.2213 67.16097 84.9948 71.37707 55.89949 48.5736 55.82556 63.72802 80.59222 47.371 47.54967 64.92126 54.18096 63.45564 59.04307 62.99639 71.69251 44.45669 45.91503 43.39417 57.75868 74.62617 23.2056 32.65348 32.3651 32.77194 33.84524 23.16247 13.81123 21.30141 22.88012 25.89401 Independent Biomarkers 25.015 22.28789 20.99405 29.30444 20.2052 37.21223 38.72015 37 33.94849 43.11032 44.77723 26.88866 21.41261 26.30114 29.06888 27.43173 29.3428 16.78541 20.13703 13.13393 30.72865 13.2382 8.87412 21.27205 16.41646 40.23991 22.23173 9.26013 25.8215 16.45448 35.75961 29.31723 Best Model 33.8104 40.04997 33.54315 41.67905 37.72078 12.91179 22.27747 15.33437 31.96203 28.79484 27.0555 23.25081 23.38803 18.95785 24.85961 16.18023 13.54991 15.33623 11.14451 23.2422 18.88915 24.3146 15.47902 17.69181 12.32071 14.58081 36.4582 39.78191 21.18962 36.49932 39.59545 35.78547 32.0905 51.7378 38.7195 24.76691 30.59412 17.46997 29.62094 47.91451 17.4069 19.52434 27.14406 31.61961 40.33113 29.3656 33.90398 34.90263 38.1339 42.07213 41.69351 52.10082 42.22469 49.57317 35.39449 30.20967 24.94091 47.84562 46.20828 23.9119 38.24344 21.65156 28.412 28.18736 49.8482 21.99386 14.80681 24.18649 23.88036 39.78749 38.18017 18.1426 35.49607 40.11149 21.60025 31.33347 15.51859 24.87374 26.04163 44.85812 22.16292 14.49694 26.54304 25.25171 37.02036 31.39971 41.683 27.38022 43.79436 19.53593 19.69994 21.33053 20.02587 45.59572 35.63632 13.7659 9.604686 11.52172 12.09339 13.69306 12.24745 14.51723 7.228416 10.14889 8.732125 10.13657 13.43503 9.604686 11.72604 23.5372 13.97319 30.24897 21.9032 24.19711 27.17996 17.25543 19.40361 24.23324 61.5711 33.81937 43.30127 41.00915 53.89573 39.19821 35.03926 36.86801 89.4511 63.36995 73.74958 63.7299 84.65518 74.47651 101.6354 78.81466 58.67282 71.06511 76.84074 76.18399 83.86447 136.424 116.5408 133.6058 148.78 131.123 145.4802 119.3199 152.8905 139.6818 23.4347 19.64443 23.21131 44.91641 32.6395 37.45555 36.7517 13.03507 21.57758 5.5 12 7.5 10.6066 7.889867 12.5499 9.578622 7.36546 13.32291 8.529361 10.149 13.096 36.139 99.159 27.012 14.142 3.4791 17.891 14.073 4.9302 13.898 18.778 24.665 28.515 21.477 16.823 17.939 45.267 58.153 49.732 13.285 29.808 27.861 27.902 23.574 10.332 23.646 17.521 23.655 18.724 27.335 15.485 22.943 20.943 17.861 25.038 24.237 22.759 13.88 8.4705 17.875 25.402 39.402 98.584 58.254 13.454 10.442 18.1 30.739 41.49 50.881 19.255 21.386 25.862 9.1378 16.109 19.119 22.293 32.074 71.786 144.25 55.541 13.509 5.2541 35.204 49.345 62.657 52.853 40.611 43.622 41.95 23.457 42.376 29.789 71.425 74.21 54.105 36.421 32.5 36.562 36.152 30.154 60.616 24.174 47.79 46.765 45.917 49.878 36.083 39.108 34.17 36.611 55.804 33.051 36.002 35.735 9.6825 32.284 53.94 84.476 165.18 85.316 16.263 22.931 46.998 62.392 86.488 66.554 41.529 40.774 68.793 32.932 42.488 34.254 26.158 49.389 87.466 126.66 65.071 12.369 16.474 51.342 52.703 46.507 33.703 40.616 51.548 64.194 41.237 46.556 45.86 94.686 99.191 101.24 34.533 42.953 45.809 47.199 28.862 34.803 33.636 23.373 37.296 19.733 18.942 62.938 72.547 57.857 44.306 58.586 41.779 41.602 40.462 9.4736 38.311 65.605 83.696 147.86 90.874 24.166 35.347 51.149 65.867 62.474 60.095 44.788 42.558 45.174 33.493 41.079 47.883 21.9032 14.37011 18.34394 25.43619 27.32215 25.69533 35.8155 36.43487 39.15035 152.386 153.6945 142.0933 128.3092 107.861 120.3723 140.6867 144.5234 114.7584 15 15 20 9 11.6619 15.55635 12.90349 10.29563 11.85327 17 11.6619 13.28533 16.97056 14.76482 14.76482 19.30026 12.74755 14.14214 17.08801 20.12461 20 12.02082 11.933 42.975 43.556 78.598 33.388 52.7 43.568 55.745 24.264 27.861 33.259 61.662 83.398 69.493 41.623 48.386 44.167 45.36 41.322 63.992 33.221 48.574 58.384 44.922 50.933 59.907 66.846 34.234 55.633 59.822 34.08 43.523 47.044 17.951 28.749 52.785 91.107 169.02 90.402 13.038 20.679 42.29 79.589 74.314 61.565 61.546 50.981 60.195 33.697 35.075 35.276 17.317 44.672 59.101 71.87 56.135 49.169 46.502 53.391 41.62 57.563 52.399 95.336 103.06 97.805 48.386 59.879 46.144 48.376 35.99 43.595 37.916 32.998 42.212 27.313 19.115 66.126 58.052 52.249 48.565 64.357 31.807 40.31 41.303 14.916 30.058 64.44 102.52 155.17 86.121 23.717 37.598 63.194 70.269 57.752 65.753 49.278 61.54 66.562 38.604 44.511 46.193 17.262 32.435 35.606 35.751 28.898 39.815 44.18 45.386 29.009 38.994 37.047 65.509 75.837 79.864 25.145 37.99 39.941 32.882 29.937 31.105 28.515 19.213 38.811 17.703 19.488 27.052 39.454 32.184 32.539 46.001 34.51 40.519 35.059 16.132 35.812 44.872 72.784 143.19 59.365 27.973 30.801 36.002 52.298 42.376 46.264 35.574 36.932 36.879 42.62 41.776 34.944 14.86 11.145 15.122 9.2113 9.5935 22.345 23.389 20.621 12.309 17.958 13.559 56.406 59.543 62.835 21.178 18.588 31.918 25.204 22.125 15.756 25.002 12.392 12.13 19.277 17.17 21.166 8.0498 16.775 19.975 15.599 28.04 25.933 27.594 13.766 14.543 34.051 64.523 102.11 63.332 12.349 16.489 20.638 38.317 34.49 52.425 17.695 26.788 25.828 17.671 17.219 15.059 22.1804 18.04476 31.12148 21.09095 23.75258 34.26334 38 26.6041 32.5912 27.57394 40.83271 48.50285 50.19225 38.68496 46.73588 45.49793 37.78749 23.29502 30.75461 42.87099 52.76482 56.0371 63.87419 72.15381 63.96221 38.58528 57.26395 29.29987 49.02038 57.81275 53.595 66.099 44.04 51.727 53.665 56.404 29.508 31.157 33.283 90.486 99.179 93.022 33.593 52.863 52.666 38.752 54.943 49.492 46.132 32.437 52.579 37.595 23.761 49.848 66.234 34.612 59.983 57.087 63.373 55.454 57.204 9.9121 29.983 68.24 92.639 163.69 95.118 14.983 29.957 57.852 76.191 59.942 68.701 58.698 48.716 44.635 39.287 35.007 35.251 36.4933 44.41335 28.56821 47.28318 52.19237 37.6283 30.83695 42.62731 34.7937 22.30107 37.52046 16.77526 34.11352 27.60075 20.56149 38.68867 58.50601 45.43585 52.49144 46.59433 61.90755 45.88399 30.31127 30.9056 42.51367 36.94713 49.04273 41.25355 43.30423 44.02245 51.83721 49.95567 21.6044 11.03404 19.39716 17.5 24.02603 17.28439 16.07016 27.06474 23.5372 21.46509 28.93959 37.59654 53.5671 47.77787 30.89579 41.021 26.64655 41.56244 40.77324 36.7015 28.97844 35.22428 30.32326 35.87478 24.20227 24.71336 25.17439 24.56624 36.01389 36.7049 34.97499 38.55516 47.22817 24.59675 26.97684 30.35622 30.60637 42.45586 27.4063 25.11424 29.89624 29.37477 121.013 105.5843 65.99251 78.08494 79.82909 97.06665 94.45523 68.0597 83.10534 89.53167 95.37643 78.15692 114.3226 96.36085 66.18341 66.04769 65.61154 96.63077 95.75197 43.9033 44.77443 47.82782 25.37716 26.29639 28.00893 34.56516 35.3235 22.45551 38.50325 36.94929 42.21374 41.60529 47.58676 37.11469 34.5 49.64625 55.11125 58.25376 46.53762 56.99781 60.44419 38.60376 31.86691 27.43173 39.21734 41.87481 31.253 39.48734 36.20428 43.15669 47.60777 55.93747 47.38934 48.81342 44.60661 21.6044 36.46231 55.18378 24.26417 32.8291 17.24819 28.92231 23.30236 52.59753 29.27456 36.1317 37.38649 64.78812 38.9551 45.30453 28.5263 34.86402 28.5263 10.0312 13.51388 19.29702 34.85147 30.03123 23.3907 32.65157 30.96571 34.25456 38.82171 38.53408 43.91327 15.99609 27.1609 21.92846 41.83129 48.36764 26.82483 18.31861 24.98571 20.52177 26.61364 32.58177 18.8035 14.75514 20.47298 31.34827 43.86831 16.49242 29.76815 26.99471 49.80534 34.89372 21.9545 21.72556 26.15722 37.32292 18.6333 21.9545 21.94994 16.28496 20.81826 31.57214 24.67793 21.83575 17.3839 17.09386 36.54586 21.2744 27.42262 37.75712 50.12385 47.16567 41.57162 43.57063 40.78725 45.00444 37.39251 78.31986 44.78616 16.49848 30.91602 23.45208 47.23346 45.51703 46.36 34.1504 22.47777 28.69669 32.76049 45.93746 33 27.6315 30.20761 32.76049 37.04727 49.48485 9 32.21801 9.66954 38.94226 28.39014 60.768 29.85381 11.16915 33.72684 23.09221 50.46781 35.17812 19.1017 18.86465 39.47943 36.00521 23.717 42.506 7.9136 22.383 32.127 27.583 30.179 23.074 25.911 24.042 27.677 28.798 25.032 16.401 28.805 17.342 22.175 35.965 63.47 133 63.583 18.398 22.275 41.173 56.283 57.354 40.898 23.686 34.463 26.968 17.073 24.92 25.158 Correlated 28 49.4816 39.11704 16.16875 26.62169 16.25247 33.78081 34.88757 10.0896 15.45962 17.12308 14.09255 18.0942 16.79286 20.76054 14.24079 20.92845 8.876936 19.834 15.192 41.061 35.319 25.338 30.143 28.082 24.522 25.97 27.228 11.769 25.588 42.172 76.758 132.14 73.475 24.839 38.51 37.115 45.119 56.865 60.265 28.623 30.367 30.303 27.991 29.572 39.425 11 32 10.982 18.857 21.749 26.207 7.9577 36.711 36.168 34.141 9.0967 10.571 26.334 42.098 92.853 52.428 18.028 16.039 17.777 7.4093 45.638 16.336 24.395 21.723 26.207 16.485 22.567 15.043 47.962 35.465 41.627 41.8 21.706 24.325 26.399 10.368 22.989 40.221 74.838 137.3 79.398 17.678 25.223 46.585 68.143 60.049 67.914 36.53 31.942 35.955 35.605 41.839 41.57 Fully 25.5147 18.94202 35.64267 36.87004 21.71635 36.092 27.35579 35.55958 54.29999 32.48602 48.74053 52.14062 53.76599 40.98157 71.20553 65.24953 26.24981 36.4712 29.6646 41.6705 20.57769 49.54569 29.57533 51.12334 26.60166 14.93586 27.86505 24.56919 41.45789 43.35701 26.3669 47.19342 21.68056 34.73456 21.53892 46.38952 35.16165 18.31942 27.98954 34.11113 39.5525 41.7229 46.23202 42.53939 47.7284 57.27478 30.2721 32.41913 26.81418 37.82856 50.14778 28.7237 27.92677 43.21941 48.65101 52.232 41.98295 23.28011 32.49563 20.98931 41.00171 43.67219 22.5587 42.84733 28.1803 41.0552 48.13939 11.0227 16.91892 14.33527 14.34399 13.24764 33.5522 29.65637 29.27456 32.1014 32.87856 34.48188 32.70321 52.1656 70.54608 47.35504 66.68958 65.63917 61.37182 72.11623 46.87217 43.09872 38.68462 66.33061 70.03571 114.777 90.31334 60.36969 64.08003 75.48344 85.04411 87.64987 139.858 144.216 140.7924 160.6168 154.6294 177.7147 86.3121 83.55231 103.1698 70.09456 97.42013 84.62645 102.4905 92.6492 109.0508 94.61112 63.32954 85.06665 72.43039 81.32232 86.07897 144.307 116.4023 137.3772 137.933 163.0659 146.5938 14 16 9 15 29 26.23928 33.35416 32.44996 29.15476 8.9221 23.262 36.861 32.645 58.555 29.387 24.036 19.365 15.898 18.145 18.887 25.313 37.483 72.119 99.404 60.089 57.965 48.004 65.266 40.515 42.573 42.261 14.246 34.79 36.449 35.718 31.395 32.729 24.585 32.969 28.328 31.472 33.469 14.556 22.742 32.593 37.568 50.755 27.473 19.289 21.752 18.021 16.591 17.813 25.9871 31.65401 32.0264 31.54434 27.18016 33.88392 35.39038 41.5226 34.13692 38.8159 31.17547 33.09323 34.24228 44.54371 42.96494 36.58795 39.74295 49.92244 44.58576 58.36651 63.36111 54.17141 32.14912 49.41759 52.68618 50.68659 46.8254 62.21566 56.17496 43.87724 66.51535 82.86804 67.34248 73.13716 80.27642 82.44501 37.63374 56.28611 43.76421 58.42628 69.19773 56.5998 43.50787 70.78665 72.79477 75.69027 59.3596 51.42449 41.31894 47.82216 51.42806 67.12578 42.69651 67.79355 85.75565 79.18051 66.61309 86.07532 80.89447 60.66686 50.37258 58.65354 56.74934 35.3136 25.34645 34.30483 37.18064 42.5281 48.54957 29.89905 52.48586 31.02699 43.42837 38.31558 54.58723 46.10875 25.18063 28.92475 26.06138 46.63666 41.60066 36.9201 44.64726 45.36598 43.73596 44.08342 35.93888 33.46684 37.0616 76.5083 88.97559 83.17453 45.11608 48.07701 50.60993 36.94431 53.51159 64.7297 50.8603 60.19333 39.81571 28.74976 29.59162 42.74911 36.98874 39.30617 25.5832 24.59167 25.44111 26.40076 22.25983 29.97499 36.09016 39.55692 34.78865 42.62335 38.41224 31.42053 24.89478 30.17449 30.89094 36.68106 20.7312 26.34269 15.33425 21.91895 27.47884 26.90512 26.15859 33.29674 39.53337 39.80173 32.04581 42.87103 26.31957 18.26741 22.58661 43.14238 34.07839 0.5 Date Correction Method_A1c Method_BMI Method_BP Method_Lipids Method_Smoke Method_MI Method_Stroke Method_DeathCHD Method_DeathStroke Method_TimeImprove 0 0 0 0 0 1 1 1 1 0 0 0 0 0 1 2 1 1 0 0 0 0 0 1 3 1 1 0 0 0 0 0 1 4 1 1 0 0 0 0 0 1 5 1 1 0 0 0 0 0 1 6 1 1 0 0 0 0 0 1 7 1 1 0 0 0 0 0 1 8 1 1 0 0 0 0 0 2 1 1 1 0 0 0 0 0 2 2 1 1 0 0 0 0 0 2 3 1 1 0 0 0 0 0 2 4 1 1 0 0 0 0 0 2 6 1 1 0 0 0 0 0 3 1 1 1 0 0 0 0 0 3 2 1 1 0 0 0 0 0 3 3 1 1 0 0 0 0 0 3 4 1 1 0 0 0 0 0 3 5 1 1 0 0 0 0 0 3 7 1 1 0 0 0 0 0 3 8 1 1 0 0 0 0 0 4 1 1 1 0 0 0 0 0 4 2 1 1 0 0 0 0 0 4 3 1 1 0 0 0 0 0 4 4 1 1 0 0 0 0 0 4 5 1 1 0 0 0 0 0 4 6 1 1 0 0 0 0 0 4 7 1 1 0 0 0 0 0 4 8 1 1 0 0 0 0 0 5 1 1 1 0 0 0 0 0 5 3 1 1 0 0 0 0 0 5 4 1 1 0 0 0 0 0 5 5 1 1 0 0 0 0 0 5 6 1 1 0 0 0 0 0 6 1 1 1 0 0 0 0 0 6 2 1 1 0 0 0 0 0 6 4 1 1 0 0 0 0 0 6 5 1 1 0 0 0 0 0 6 6 1 1 0 0 0 0 0 6 7 1 1 0 0 0 0 0 6 8 1 1 0 0 0 0 0 7 1 1 1 0 0 0 0 0 7 3 1 1 0 0 0 0 0 7 4 1 1 0 0 0 0 0 7 6 1 1 0 0 0 0 0 7 7 1 1 0 0 0 0 0 8 1 1 1 0 0 0 0 0 8 3 1 1 0 0 0 0 0 8 4 1 1 0 0 0 0 0 8 6 1 1 0 0 0 0 0 8 8 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 7 1 1 1 1 1 1 1 1 8 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 4 1 1 1 1 1 1 1 2 6 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 3 2 1 1 1 1 1 1 1 3 3 1 1 1 1 1 1 1 3 4 1 1 1 1 1 1 1 3 5 1 1 1 1 1 1 1 3 7 1 1 1 1 1 1 1 3 8 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 4 2 1 1 1 1 1 1 1 4 3 1 1 1 1 1 1 1 4 4 1 1 1 1 1 1 1 4 5 1 1 1 1 1 1 1 4 6 1 1 1 1 1 1 1 4 7 1 1 1 1 1 1 1 4 8 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 5 3 1 1 1 1 1 1 1 5 4 1 1 1 1 1 1 1 5 5 1 1 1 1 1 1 1 5 6 1 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 6 2 1 1 1 1 1 1 1 6 4 1 1 1 1 1 1 1 6 5 1 1 1 1 1 1 1 6 6 1 1 1 1 1 1 1 6 7 1 1 1 1 1 1 1 6 8 1 1 1 1 1 1 1 7 1 1 1 1 1 1 1 1 7 3 1 1 1 1 1 1 1 7 4 1 1 1 1 1 1 1 7 6 1 1 1 1 1 1 1 7 7 1 1 1 1 1 1 1 8 1 1 1 1 1 1 1 1 8 3 1 1 1 1 1 1 1 8 4 1 1 1 1 1 1 1 8 6 1 1 1 1 1 1 1 8 8 1 1 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 50 Models x 4 Assumptions Jacob Barhak Version 22 - MIST_RefModel_2014_04_29_MATRIX_TraceBack.zip
Temporal Medical Improvement Hypothesis The 0.6 HRR was translated to yearly probability decrease for: MI , Stroke, MI Death, Stroke Death This probability was adjusted for time passed between: Model year = average of Model Data Time Interval Simulated Time Stamp = simulated study year/s Model Data Time Interval Simulated Time Stamp Time Adjustment Time This correction term accounts for model outdate Jacob Barhak
From Competition to Cooperation Eq EH E E E E A B Process CHD Eq AD A 4 B 6 C 2 D 1 aA+bB+cC+dD Pop 3 D C Pop 1 CHD Death 2 4 6 1 No CHD MI Survive MI Pop 2 Pop 2 2 3 9 2 Pop 3 Pop 1 E F Process Stroke eE+fF+gG+hH Discrete Fitness Matrix Death H G Survive Stroke Stroke Death No Stroke Stroke Process Competing Mortality Other Death Alive Linear combination rather than one risk equations Ensemble model where models cooperate Fitness in continuous space rather than discrete space Reduce computation time for best fitting model Best model more accurate Continuous Fitness Space Jacob Barhak
The Assumption Engine The Assumption Engine allows us to throw assumptions at it A model is an assumption! It figures out which assumptions work well together to fit observed data Points to significant models Rejects incompatible models Jacob Barhak
Temporal Medical Improvement Calculated Data and model from 3 decades Multiple models were used with model stamps ranging from 1978.5 to 2007.05 Validated against 9 populations included in the period ranging from 1977 to 2010 The assumption engine was asked to calculate the best fit: Significance of each model used The yearly improvement coefficient The prevention coefficient = indicating if improvement is pre event or post event ??????????= ???? Model Data Time Interval Simulated Time Stamp Time Adjustment Time Jacob Barhak This correction term accounts for model outdate
The Assumption Engine Results Temporal + Bio-Marker Temporal Control Bio-Marker Control 1 Dominant Dominant Dominant Dominant equations equations equations equations Rejected equation 0.9 Minor difference 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 Fitness / 100 MI Eq. 1 MI Eq. 2 MI Eq. 3 MI Eq. 4 MI Eq. 5 MI Eq. 6 MI Eq. 7 MI Eq. 8 MI Eq. 9 MI Eq. 10 MI Eq. 11 Stroke Eq. 1 Stroke Eq. 2 Stroke Eq. 3 Stroke Eq. 4 Stroke Eq. 5 Stroke Eq. 6 Stroke Eq. 7 Stroke Eq. 8 Stroke Eq. 9 Stroke Eq. 10 Stroke Eq. 11 Stroke Eq. 12 Death MI Eq. 1 Death MI Eq. 2 Death MI Eq. 3 Death Stroke Eq. 1 Death Stroke Eq. 2 Death Eq. 1 Death Eq. 2 Prevention Coefficient CVD 6 Yr Coefficient Yearly CVD Coefficient Other Death MI Stroke MI Temporal Correction Better Fits Data Death Stroke Death Temporal Improvement Reproducibility Info: MIST_RefModel_2016_10_26_OPTIMIZE.zip using model version 44 MIST_RefModel_2016_12_17_OPTIMIZE.zip using model version 45 Jacob Barhak
Results Summary Halved every 5 years Yearly Temporal Correction CVD Coefficient =0.86/0.87 from 1978.5 to 2007.05 Slightly better than Gregg et. al. Transformed For 6 years = 0.41/0.44 Gregg et. al. reports 0.6 (0.46 - 0.77) for 2003 2004 vs. 1997 1998 Still within similar range Is medical improvement rate slowing down? Similar improvement of prevention and post event treatment The Prevention coefficient =0.43/0.53 Jacob Barhak
How Reliable Are These Results? Noise Data Human Error These results do contain human entry error Data Monte Carlo Probably stable enough - enough data was accumulated 9 populations Are models representative? Missing data estimated dates Model Assumptions Improvement rate Formulation Ensemble model formulation Optimization Multiple possible solutions Arbitrary stopping criteria Similar results reported in the past so probably not far from the truth Jacob Barhak
Conclusions We can calculate how fast Medical practice is improving fast! New disease models should include temporal correction for medicine improving Especially when estimating long term phenomena such as life expectancy The Reference Model accumulates knowledge towards a wider view It can now extract such data from ClinicalTrials.Gov Jacob Barhak
Acknowledgments Deanna J.M. Isaman - who is the spirit behind the great ideas. She taught me my first steps in disease modeling Morton Brown & William H. Herman for guidance, critical feedback, and growth environment Nicke Ide and the NIH program officers that connected me to him to allow creating the interface with ClinicalTrials.Gov Continuum Analytics and specifically: Benjamin Zeitler for creating the cloud AMI Ilan Schnell for his work on Anaconda. All those who developed free software used and supported it: including Python, Anaconda, Spyder, numpy, SciPy, nose, winpdb, Star Cluster, Ubuntu, Sun Grid Engine The legacy IEST modeling framework was supported by the Biostatistics and Economic Modeling Core of the MDRTC (P60DK020572) and by the Methods and Measurement Core of the MCDTR (P30DK092926), both funded by the National Institute of Diabetes and Digestive and Kidney Diseases. The modeling framework was initially defined as GPL and was funded by Chronic Disease Modeling for Clinical Research Innovations grant (R21DK075077) from the same institute. MIST is based on IEST. The Reference Model and MIST were developed independently without financial support Jacob Barhak
Questions? Jacob Barhak http://sites.google.com/site/jacobbarhak/ Jacob Barhak
