Mendel's Experiments Uncovering Genetics Fundamentals
Mendel's groundbreaking work on inheritance patterns using pea plants revolutionized the field of genetics. By studying traits with distinct variations, Mendel disproved the blending hypothesis, leading to the understanding of dominant and recessive alleles in monohybrid crosses. His use of true-breeding lines and hybridization laid the foundation for modern genetic principles.
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Presentation Transcript
Executive Summary Shavahn Loux, PhD
GenomEqs Shavahn Loux, PhD
Venture Overview / Introduction 2 paragraphs Paragraph 1 (Problem) What are you doing Why is it important? Paragraph 2 (Solution) What sets you apart? Why are you better?
Our DNA is the blueprint of who we are. Not only can it predict basic physical traits such as height and weight, it can also tell us about our ancestry, about our propensity to develop disease and even information about our athletic potential. As such, genomic analysis, or the act of evaluating markers in our DNA, is an intensely powerful tool to gain knowledge about ourselves and our animals. At GenomEqs, we are bringing large-scale genomic analysis to the horse.
Our DNA is the blueprint of who we are. Not only can it predict basic physical traits such as height and weight, it can also tell us about our ancestry, about our propensity to develop disease and even information about our athletic potential. As such, genomic analysis, or the act of evaluating markers in our DNA, is an intensely powerful tool to gain knowledge about ourselves and our animals. At GenomEqs, we are bringing large-scale genomic analysis to the horse.
Our DNA is the blueprint of who we are. Not only can it predict basic physical traits such as height and weight, it can also tell us about our ancestry, about our propensity to develop disease and even information about our athletic potential. As such, genomic analysis, or the act of evaluating markers in our DNA, is an intensely powerful tool to gain knowledge about ourselves and our animals. At GenomEqs, we are bringing large-scale genomic analysis to the horse.
Our DNA is the blueprint of who we are. Not only can it predict basic physical traits such as height and weight, it can also tell us about our ancestry, about our propensity to develop disease and even information about our athletic potential. As such, genomic analysis, or the act of evaluating markers in our DNA, is an intensely powerful tool to gain knowledge about ourselves and our animals. At GenomEqs, we are bringing large-scale genomic analysis to the horse.
Our DNA is the blueprint of who we are. Not only can it predict basic physical traits such as height and weight, it can also tell us about our ancestry, about our propensity to develop disease and even information about our athletic potential. As such, genomic analysis, or the act of evaluating markers in our DNA, is an intensely powerful tool to gain knowledge about ourselves and our animals. At GenomEqs, we are bringing large-scale genomic analysis to the horse.
Despite the popularity of genomic testing in other animals, this technology does not exist on a large scale in the horse despite their potential to be more economically productive on an individual level. Current commercial testing is limited to one to five genes which analyze single traits, mostly crippling genetic diseases or basic color genetics. No commercial testing exists for numerous factors which directly affect the health and well-being of horses despite significant research into these traits. We are confident that the information gained from large-scale genomic testing will improve the health and wellbeing of horses on an individual basis, and on a breed-wide basis.
Value Proposition
Value Proposition Going far beyond single gene analysis, GenomEqs is an equine genomics company looking to revolutionize the way horses are managed. We are unique because our test looks at over 670,000 genetic markers to identify and characterize 75 + traits affecting the health and well-being of the horse. Requirements for owners to test their horse will be minimal. Results will be provided as a professional quality printout and pdf, clearly and fully explaining the results of each test in lay language, including how that information affects their individual horse.
Market Market size 9.2 million horses in the US 280,000 foals born annually Breeding Farms Individual Horse Owners Veterinarians Breed Associations Insurance Companies Equine Researchers
Market Strategy STEP 1: A sales force to visit breeding farms and breed organizations individually and sell them on the benefits of using GenomEqs to optimize their management practices. This will include interaction with horse owners at sales and events as well. STEP 2: A website which allows both the sale of testing kits and interaction with DNA test results. STEP 3: Veterinary associates who will receive a percentage of sales in exchange for selling the kits.
Financials The cost / plate reaches break-even at 27 samples.
Low Price Mid Price High Price Revenue Gross Profit Revenue Gross Profit Revenue Gross Profit Sample # Total Cost Low Volume 96 $ 15,503 $ 52,704 $ 37,201 $ 71,904 $ 56,401 $ 95,904 $ 80,401 Mid Volume 288 $ 46,510 $ 158,112 $ 111,602 $ 215,712 $ 169,202 $ 287,712 $ 241,202 High Volume 480 $ 77,516 $ 263,520 $ 186,004 $ 359,520 $ 282,004 $ 479,520 $ 402,004
Sales Projections Samples / month 1st year - 96 samples a month (one plate) 0.04% of the 2018 Thoroughbred foal crop 1200 1000 800 600 2nd year - 288 samples / month (3 plates) 400 200 0 Year 1 Year 2 Year 3 3rd year - 960 samples / month (10 plates) 4 % of the 2018 Thoroughbred foal crop 0.34% of all 2018 foals born in the US.
Formatting Header/Footer Graphs Pictures
Health Traits limbal squamous cell carcinoma macrophage activation malignant hyperthermia maxillary prognathism megacolon melanoma Athleticism fracture risk myostatin regulation temperment precocity racing distance performance (CKM, COX4I2) performance (ACTN3) performance (MSTN - SI) performance (MSTN) performance (PDK4) performance (PRKAG3) Color and Conformation body size amylase expression androgen insensitivity syndrome atlanto occipital fusion atrial fibrillation cerebellar abiotrophy congenital hepatic fibrosis congenital stationary night blindness myotonia copper-zinc ratio dwarfism EAV resistance ehlers-danlos syndrome, type IV naked foal syndrome navicular occipotatlantoaxial malformation ocular anomalies epidermolysis bullosa equine metabolic syndrome osmotic fragility of erythrocytes osteochondrosis ovotesticular disorder of sexual development parentage testing polysaccharide storage myopathy pulmonary hemorrhage recurrent airway obstruction rhabdomyolosis (tying up) sarcoids severe combined immunodeficiency disease skeletal atavism swayback thrombasthenia trisomy urticaria uveitis fertility - female fertility - male foal immunodeficiency syndrome glycogen storage disease guttural pouch tympany hoof wall separation syndrome hydrocephalus bone density color - agouti color - brindle color - champagne color - chestnut color - cream dilution color - dominant white HYPP immune-mediated myositis incontinentia pigmenti innate immunity insect bite hypersensitivity juvenile idiopathic epilepsy laryngeal neuropathy (roarer) lavender foal syndrome color - dun color - gray color - leopard complex color - macciato color - recessive black color - sabino color - silver color silver color - solid white Table 1. Traits included in genomic analysis report color - splashed white color - tobiano color - white spotted color - white spotted, deafness curly coat gait qualities gaitedness height tiger eye
Other things to consider discussing The competition, specific companies Funds required Key partnerships Researchers Veterinarians Partnering companies Affymetrix Neogen
