MitoVariome: Human Mitochondrial DNA Database
"Explore the MitoVariome database showcasing over 5,000 complete human mitochondrial DNA sequences. Discover rapid evolutionary rates, absence of recombination, and variations for studying human evolution, forensics, and aging. Uncover the application of MitoVariome for understanding individual variations, haplogroups, and geographical locations. See examples like the Korean genome sequence (SJK) and its significance in genetics research."
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Presentation Transcript
8 8th thInCoB InCoB 2008 2008 Singapore Singapore MitoVariome: A variome database of human mitochondrial DNA Yong Seok Lee Korean BioInformation Center, KRIBB
Human mitochondrial DNA Maternally inherited Rapid evolutionary rate Lack of introns Absence of recombination Circular DNA, 16,569 bp 22 tRNAs, 2 rRNAs, 13 protein coding genes, and a non-coding region 2
Mitochondrial DNA sequence variation in human Having variation features (HVSI, HVSII, SNP, restriction enzyme sites, and STR) Providing critical information for studying human evolution, forensics, and aging process 3
MitoVariome Over 5,000 complete human sequences of mitochondrial DNA Geographic location and haplogroup to elucidate the history of human evolution Linked to GenBank and Pubmed database Showing a graphical view of the variation information 5
Application of MitoVariome Useful for understanding mitochondrial variations of each individual, haplogroup, or geographical location Understanding of variation and its relationship with human evolution and disease Assignment of haplogroup 9
Example of MitoVariome A Korean genome (SJK) The first full length Korean individual genome sequence 10
Example of MitoVariome A Korean genome (SJK) The first full length Korean individual genome sequence 11
Conclusion A database and analysis server for human mitochondrial DNA variation A platform to retrieve all kinds of variation information The function to assign haplogroup with user SNP data Available at http://variome.kobic.re.kr/MitoVariome 12
