Molecular Research on Alzheimer's Disease in Saudi Patients
Explore molecular research on Alzheimer's disease in Saudi patients and its applications, including genetic causes, neuropathological features, and personalized treatments. Discover insights on neurodegenerative disorders, dementia, neuronal loss, and more from a Molecular Biology Conference in Dubai, UAE.
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Presentation Transcript
Molecular Research on Alzheimers Disease of Saudi Patients and its Applications Trip to look for memory Molecular Biology Conference, Dubai, UAE.10-11 October 2016
Neurodegenerative disorder Dementia Neuronal loss LOAD >65 Sporadic Autosomal Dominant EOAD <65 Familial
Neuropathological Feature of Alzheimers Disease Alzheeimer A. Allg Z Psychiatr 1907 Brain Atrophy Advanced Alzheimer s Healthy Brain Cortical Shrinkage Enlarged ventricles Hippocampus Shrinkage https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcRS1y9NPwNM_FBLwxzwvMKPX9EV4Q2JBJlb7QvpO0OF5DLZoKpW Neuronal Plaques Neurofibrillary Tangles
Applying Alzheimers Research In Saudi Patients To Personalized Treatment Patient
Genetic Cause of Alzheimers Disease Early Onset Familial AD (~5%) Late Onset AD APP 18exons Chr21 APOE *APOE4 Chr 19 PSEN2 12 exons SORL1 49 exons Chr14 Chr11 PSEN1 12 exons Amino acid substitution Beta amyloid fragment Chr1
PSEN & APP Role in Beta Amyloid Overproduction -secretase Pathway: APP Protein: (1) -secretase cuts APP protein, giving: PSEN (2) -secretase cuts this residue, giving: A 40 Fragment Soluble or A 42 Fragment Unsoluble, aggregates into plaques
In the present study, we examined mutations related to Genetic Components of EOAD and to LOAD
Molecular Biology Conference, Dubai, UAE.10- 11 October 2016
