NADH Fate in Cellular Metabolism
Explore the intricate pathways involved in the fate of NADH in cellular metabolism, including aerobic and anaerobic processes such as the Malate Aspartate Shuttle, Glycerol-3Phosphate DHAP Shuttle, and the Cori Cycle. Learn how NADH is recycled and its significance in energy production.
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Presentation Transcript
Glycolysis The Fate of NADH
NADH in Recycling in the Cytoplasm Aerobic Pathway Aspartate/Malate Shuttle Glycerol 3-phosphate-DHAP Shuttle Anaerobic Pathway Lactate and the Cori Cycle Ethanol production (in yeast)
Malate Aspartate Shuttle System Malate Dehydrogenase Aspartate Aminotransferase Figure modified from: Son, H.F. and Kim, J-J. (2016) PLoS One 10.1371
Malate Malate Aspartate Shuttle System Aspartate Shuttle System Aspartate Aminotransferase Oxaloacetate Malate Glutamate Dehydrogenase Malate -ketoglutarate NADH Aspartate NAD+ IM Space Matrix Malate Aspartate Glutamate -ketoglutarate Malate Dehydrogenase NAD+ Oxaloacetate Aspartate Aminotransferase NADH
Glycerol-3 Phosphate DHAP Shuttle Figure from Boghog2
Summary of Aerobic Pathway of NADH Oxidation Malate Aspartate Shuttle Preserves the NADH NADH worth ~3 ATP in this process Glycerol 3 Phosphate DHAP Shuttle converts NADH to FADH for entry into the Electron Transport Chain. NADH worth ~1.8 ATP in this process
Anaerobic Metabolism in Animals NADH/H+ NAD+ Lactate Dehydrogenase Pyruvate Lactate Figure modified from Zlir a
Formation of lactate allows recycling of NADH to NAD+ in the cytoplasm Figure from Boundless Biology, LumenCandella
The Cori Cycle To Bloodstream Glucose Glucose Pyruvate To Muscle NADH NAD+ 2 ATP Pyruvate NADH NAD+ To Liver Lactate To Bloodstream Figure modified from Servier Medical Art
