Nephrotic Syndrome
Nephrotic syndrome is a collection of symptoms indicating kidney damage, with conditions like Minimal Change Disease, Focal Segmental Glomerulosclerosis, Membranous Glomerulonephrosis, and Membranoproliferative Glomerulonephrosis discussed here. Learn about the classification, primary and secondary causes, pathophysiology, signs and symptoms, diagnostic tests like urine analysis and kidney biopsy, and more.
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Presentation Transcript
NEPHROTIC SYNDROME MPGN MGN MCD FSGS Dr. Robin Chaudhary M.D.(Ayu) Assistant Professor Department of Kaumarbhritya
Definition It is a Collection of Symptoms due to damage to the Kidney or Nephrotic syndrome is a collection of symptoms that indicate kidney damage
Terminology MCD: Minimal Change Disease FSGS: Focal Segmental Glomerulosclerosis MGN: Membranous Glomerulonephrosis MPGN: Membranoproliferative Glomerulonephrosis
Classification Nephrotic Syndrome Glomerular Disease that is limited to Kidney Also Known as Peimary Glomerulonephrosis Diagnosis of Exclusion Primary Nephrotic Syndrome Secondary Nephrotic Syndrome Underlying Condition/Cause that affects Kidnay & also other body organs/parts
Primany Glomerulonephrosis Based on the Cause Minimal Change Disease Focal Segmental Glomerulosclerosis Membranous Glomerulonephrosis Membranoproliferative Glomerulonephrosis Most common in Childrens( 2 6 yrs) Most common in childrens & Adolocent Common in both Childrens & Adults Most common in Adults
Diabetic Nephropathy Drugs SLE/Lupus Nephritis Secondary Nephrotic Syndrome Genetic Nephrotic Syndrome Hepatitis B Cancer HIV
Pathophysiology Inflammation Hyalinization Primary/Secondary Causes Protien/Albuminuria Low Oncotic Pressure in Vessels(Vascular System) Flow in Interstetial Spaces Edema Proteinuria Hypoalbuminemia Puffiness Under Eyes Pitting edema in legs Fluid in Lungs (Pleural Effusion) Fluid in Perietal Cavity (Ascites) Generalised Fluid Accumulation (Anasarca) Hyperlipidemia (due to Lipoproteins)
Sign & Symptoms Mainly Albumin 40 g/m2/body square meter/24hr Proteinuria <2.5 g/dl 3.5 5 gm/dl (Normal) Hypoalbuminemia Hyperlipidemia Mainly LDL & VLDL
Urine Analysis Blood Tests Auto- Immune Markers Kidney Biopsy
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