Nested Model for Additive Variance Drivers
Analyzing gene-level and SNV-level additive variances within different tissues such as breast, CNS, kidney, liver, ovary, pancreas, prostate, and skin. The study provides insights into the coding and non-coding regions, highlighting potential drivers of genetic variation. Explore the results and implications of the additive variance models.
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Presentation Transcript
Nested model for additive variance Additive variance Drivers Coding Promoters Non-coding Total Breast 0.5064 0.1675 0.3932 0.5163 0.6256 0.9497 0.2152 0.929 0.5379 0.0221 0.0274 0.2513 0.0466 0.0405 0.0269 0 0.5555 0.205 0.8468 0.7476 0.7847 0.9555 0.3588 CNS 0 0 0.01 Kidney 0.2023 0.1796 Liver 0.005 0.1186 0.0058 Ovary 0 0 Pancreas 0 Prostate 0.1413 0 0.0022 0.0644 0.0573 Skin 0 0.0066 0.0204 1 Pan-cancer 0.0662 Previous results 0.6817 Drivers Ncd+prm All Pan-cancer 0.525 0.5795 0.6455 1
Gene-level additive variances & q-values Gene-level additive variances & q-values Non-coding +Coding Non-coding +Coding Breast 40.6% q = 0.094 53.6% q= 0.0013 Breast - q = ns - q= - PCAWG Neutral Model MoatV Results CNS 0.3% q = 0.47 9.2% q = 0.097 CNS 2.56% q = 0.78 11.29% q = 0.14 Kidney 51.7% q = 0.026 65.6% q = 6.4e-9 Kidney - q = - - q = - Liver 99.9% q = 2e-10 100% q = 1.9e-9 Liver - q = - - q = - Ovary 64.2% q = 0.12 63.5% q = 5.4e-6 Ovary 46.92% q = 0.2694 72.49% q = 0.004 Pancreas 83.2% q = 4.1e-5 72.5% q = 0.0012 Pancreas 90.86 q = 0.0 81.07 q = 0.0001 Prostate 18% q = 0.27 29.6% q = 1.4e-5 Prostate 21.76% q = 0.3398 26.75% q = 0.004 Skin 74.8% q = 1e-4 75.5% q = 7.2e-5 Skin - q = - - q = - Median: 64.55 (43.7) FDR < 0.1 Med: 57.95(41.4) FDR < 0.1 Med: 34.34(40.4) FDR - Median: 49.62 (47.8) FDR -
SNV-level additive variances & q-values SNV-level additive variances & q-values Non-coding +Coding Non-coding +Coding Breast 42.9% q = 3.6e-9 46.4% q = 4e-9 Breast 41.9% q = 1e-8 45.1% q = 7e-9 PCAWG Neutral Model CNS 15.3% q = 2e-4 19.2% q = 1e-4 CNS 15.2% q = 7e-4 19% q = 1e-4 MoatSim Results Kidney 52% q = 1.5e-11 56.7% q = 1.6e-11 Kidney 54.1% q = 5e-11 58.2% q = 3e-11 Liver 67.8% q = ~0 74.8% q = ~0 Liver - q = - - q = - Ovary 59.2% q = 4.4e-12 67.7% q = 4.8e-12 Ovary 62.3% q = 6e-11 67.1% q = 6e-11 Pancreas 87.1% q = ~0 90% q = ~0 Pancreas - q = - - q = - Prostate 60.9% q = 1.8e-10 66.7% q = 1.8e-10 Prostate 60.1% q = 3e-10 65.3% q = 1e-10 Skin 14.6% q = 9e-4 21.6% q = 9e-4 Skin - q = - - q = - Drivers only: Median: 52.5 Median: (46.1) FDR < 0.001 Median: 61.7(51.34) FDR < 0.001 Median: (46.7) FDR - Median: (50.94) FDR - 4
Gene-level additive variances & q-values Gene-level additive variances & q-values Non-coding +Coding Non-coding +Coding Breast 40.6% q = 0.094 53.6% q= 0.0013 Breast 1.3% q = ns 48.4% q= 7.2e-6 PCAWG Neutral Model CNS 0.3% q = 0.47 9.2% q = 0.097 CNS 0% q = - 9.2% q = 0.26 MoatSim Results Kidney 51.7% q = 0.026 65.6% q = 6.4e-9 Kidney 0% q = - 65.8% q = 6.5e-8 Liver 99.9% q = 2e-10 100% q = 1.9e-9 Liver - q = - - q = - Ovary 64.2% q = 0.12 63.5% q = 5.4e-6 Ovary 0% q = - 60.3% q = 1.6e-5 Pancreas 83.2% q = 4.1e-5 72.5% q = 0.0012 Pancreas - q = - - q = - Prostate 18% q = 0.27 29.6% q = 1.4e-5 Prostate 0.4% q = - 26.5% q = 0.0003 Skin 74.8% q = 1e-4 75.5% q = 7.2e-5 Skin - q = - - q = - Med: 57.95(34.9); FDR < 0.1 Med: 0; FDR - Median: 64.55(44.3) FDR < 0.1 Median: 48.4(42.5) FDR < 0.001 4 (Except CNS,Ov,Prost) (Except CNS)
