Neuropsychological and Brain Volume Differences in Corticobasal Syndrome Patients
This study investigates differences in left and right beginning Corticobasal Syndrome (CBS) patients regarding brain volume and cognitive functions. Research reveals unique patterns of atrophy, cognitive impairment, and motor functions in l-CBS and r-CBS individuals. Understanding these differences can aid in identifying potential hemispheric susceptibilities to disease-related changes.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
You are allowed to download the files provided on this website for personal or commercial use, subject to the condition that they are used lawfully. All files are the property of their respective owners.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.
E N D
Presentation Transcript
Neuropsychological and brain volume differences in patients with left and right beginning Corticobasal Syndrome K. J tten, P. Pieperhoff, M. S dmeyer, S. Ferrea, S. Caspers, K. Zilles, A. Schnitzler, Mitglied der Helmholtz-Gemeinschaft K. Amunts, S. Lux Plos One, in press 19. September 2014 | Prof. (apl.) Dr. Silke Lux
Introduction Cortico basal syndorme (CBS) characteristics: Background: Previous studies did not separate left (l-) from (r-) right beginning CBS patients Describtion: - atypical parkinson syndrom - very rare (< 4:100 000) - progressive - begin around age 60 Clinical signs: Movement impairment: - starts unilateral (one sided) - paucity of movement - muscle rigidity - tremor Cognitive impairment: - language symptoms - later other cognitive symptoms Research question: Differences in l-CBS and r-CBS in local brain volume and cognitive functions Evidence of differences in hemispheric susceptibility to disease- related changes Mitglied der Helmholtz-Gemeinschaft 19.09.2014 Prof. (apl.) Dr. S. Lux 2
Methods Subjects Measurements Brain volume Deformationfield-based Morphometry (DBM) on structural MRI l-CBS r-CBS controls 4 4 8 N (2/2) (2/2) (4/4) Gender (m/f) Age in years (SD) Cognitive functions Neuropsychological investigation (11 tests) 68 (9) 68 (4) 65 (8) Duration in years (SD) 3,5 (1) 3,8 (1) - Mitglied der Helmholtz-Gemeinschaft 19.09.2014 Prof. (apl.) Dr. S. Lux 3
Results Brain volume differences Cognitive functions l-CBS r-CBS Memory + + verbal working memory + + visual spatial working memory - + verbal episodic memory + + figural memory Attention + + procession speed Executive functions + + affinity of interference Language - + word fluency + + naming Perception l-CBS: Atrophy: fronto-parietal, orbitofrontal, temporal NP: apraxia, memory, perceptional deficits Mitglied der Helmholtz-Gemeinschaft - + object - + space Motor functions r-CBS: Atrophy: predominatly fronto-parietal NP: apraxia -- - apraxia left - -- apraxia right 19.09.2014 Prof. (apl.) Dr. S. Lux
Summary and Conclusion Left- and right-beginning CBS are differently affected with respect to brain volume reduction and extent of NP impairment Side of clinical onset may have impact on manifestation and development of symptoms Hemispheres might be differently able to cope with disease-related changes Mitglied der Helmholtz-Gemeinschaft Considering side of clinical onset in CBS can help to reduce the heterogeneity of clinical evidence 5 Prof. (apl.) Dr. S. Lux 19.09.2014
Methods Function Memory Verbal working memory Test Digit-span test, Subtest of the N rnberger-Alters Inventar Visual-spatial working memory Corsi Block Tapping Test (CBT) Verbal episodic memory Verbaler Ged chtnistest (VGT) Figural memory Figure test (FT) Subtest of the N rnberger-Alters Inventar Attention Processing speed Zahlen-Verbindungs-Test (ZVT-T1) German subtest of the N rnberger-Alters Inventar Executive functioning Affinity of interference Language Word fluency Naming Perception Object Space Farb-Wort-Interferenz Test (FWIT) Controlled oral word association test (COWAT) Naming Subtests of the Aachener Aphasie Test Incomplete letters (IL) Number location (NL) Subtests of the Visual Object and Mitglied der Helmholtz-Gemeinschaft Space Perception Battery Bildunterschrift Motor skills Apraxia Florida Apraxia Screening Test (FAST) 6
Results Two case studies (6 months follow-up) Brain volume differences l-CBS Left CBS Right CBS Body side of onset Years of education 9 10 f f Gender r-CBS 57.6 y 63.4 y Age at t1 3.8 y 4.0 y Duration at t1 Mitglied der Helmholtz-Gemeinschaft Cognitive functions: l-CBS : worsening of verbal fluency, visuo-perception and apraxia, but especially of memory functions r-CBS : worsening of verbal memory but especially of apraxia 19.09.2014 7 Prof. (apl.) Dr. S. Lux
