Neurotrophic Factors and Cellular Mechanisms in Brain Development

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Explore the role of programmed cell death, apoptosis, nerve growth factor, BDNF, cell adhesion molecules, and more in brain development. Learn about the guidance of axons, differentiation, cell proliferation, and signaling chemicals. Discover how rehabilitation strategies aid individuals in overcoming injuries.

  • Brain Development
  • Neurotrophic Factors
  • Cell Mechanisms
  • Axon Guidance
  • Rehabilitation

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Presentation Transcript


  1. Programmed cell death 1

  2. apoptosis 1

  3. Nerve growth factor and ____ are two of the key neurotrophic factors in the brain. 2

  4. brain-derived neurotrophic factor (BDNF) 2

  5. molecules that adhere to the growth cone and help the axon move in the correct direction (Developing axons are guided to their final destinations by chemoattractants, chemorepellants, and ____ ____ molecules.) 3

  6. cell adhesion molecules (CAMs) 3

  7. differentiation that occurs without the help of inductive signals from nearby cells 4

  8. cell-autonomous 4

  9. the rapid growth in the number of cells during development 5

  10. cell proliferation 5

  11. chemicals that provide a trail for migrating cells to follow 6

  12. chemoattractants 6

  13. chemicals that repel migrating cells 7

  14. chemorepellants 7

  15. rehabilitation strategies that focus on providing new ways for individuals to carry out tasks made difficult by their injury 8

  16. compensatory strategies 8

  17. rehabilitation strategies that encourage the individual to use their impaired limb to carry out tasks, and to repeat the task again and again 9

  18. constraint-induced movement therapy 9

  19. the process by which a cell becomes a specialized type of cell 10

  20. differentiation 10

  21. the embryonic layer that gives rise to the skin and the nervous system 11

  22. ectoderm 11

  23. death of a neuron caused by its overexcitement 12

  24. excitotoxicity 12

  25. a structure at the tip of a growing axon that senses axon guidance chemicals 13

  26. growth cone 13

  27. a chemical signal that triggers an undifferentiated cell to become a cell with a particular morphology 14

  28. inductive signal 14

  29. the long-term weakening of a synapse 15

  30. long-term depression (LTD) 15

  31. the long-term strengthening of a synapse 16

  32. long-term potentiation (LTP) 16

  33. a cells size, shape and structure 17

  34. morphology 17

  35. a chemical that promotes neuronal growth and prevents apoptosis 18

  36. nerve growth factor (NGF) 18

  37. a cell destined to become a neuron or glial cell 19

  38. neural progenitor cell 19

  39. a tube-like structure formed when the ectoderm closes in upon itself during development 20

  40. neural tube 20

  41. the birth of neurons 21

  42. neurogenesis 21

  43. substances that feed and nourish brain cells 22

  44. neurotrophic factors 22

  45. the type of glial cell that produces myelin in the central nervous system 23

  46. oligodendrocyte 23

  47. the general name for immature cells capable of giving rise to various cell types (p___ cells) 24

  48. pluripotent cells 24

  49. the general name for cells that differentiate to become a specialized cell type 25

  50. progenitor cells 25

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