"Explore the progress and challenges outlined in the MESA Operations Subcommittee Report. Delve into timelines, follow-up calls, exam details, participant relations, and retention rates. Gain insights into completion rates by ethnicity and site, highlighting areas needing focus for improved outcomes."
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MESA 3 Timeline Exam 6 Sept 6, 2016 March 30, 2018 Annual Follow-up phone calls run congruent with fiscal years
Follow-up Calls Follow-up 16 Ended 7 months early in August 2015 Medications inventory, new questions for gout, food security, e-cigarette use, blood thinner/anticoagulant use Follow-up 17 Started August 2015 (60% complete) New MESA 3 follow-up schedule Permission to send letter to Contacts with information about MESA and role as a Contact
Follow-up Retention by Site WFU Columbia JHU 100 90 85% 80 70 60 50 40 Minnesota NWU UCLA 100 90 85% 80 70 60 50 40 Retention = Completed / (Enrolled Dead) except FU 17 (windowed)
Follow-up 17 Completion by Site Follow-up Due Interviews Completed Site Name Contacts Made Unable Refused Wake Forest Columbia Hopkins Minnesota NWU UCLA Total 436 437 388 448 501 521 2731 384 373 370 426 487 449 2489 88% 85% 95% 95% 97% 86% 91% 320 321 328 378 432 370 2149 73% 73% 85% 84% 86% 71% 79% 53 47 40 44 50 77 311 10 5 1 4 5 1 26 Completed = Completed / (Enrolled Dead Dropped)
Retention Follow-up 16 Low (expected/truncated) Follow-up 17 All sites behind schedule Particularly among minority groups Important to focus on call completion now Limited call (contacts, events) available
Exam 6 Core #Participants Time Burden ~ 4000 ppts Average duration: 90 minutes Consent/Check-in Seated blood pressure, pulse oximetry Anthropometry Phlebotomy Medical history (SF-12, PROMIS Physical Function) Personal history/demographics Medication Inventory Exam components
Exam 6 Ancillary Studies PI Sample Title Bertoni, Shah Transition from risk factors to early HF Pulmonary microvascular perfusion in MESA All 2000 (All sites) 650 (All sites) 1500 (All sites) 550 (Wake) 350 (CU) Barr Smith COPD in non-smokers Atrial fibrillation & vascular disease of the brain Cardiometabolic risk for Alzheimer's HDL-mediated cholesterol efflux and carotid FDG PET Heckbert Hughes, Craft Shea
Exam 6 Components (~Day 1) Time 15 5 15 0 10 15 5 Sample All All All All All All All All All All? 2650 2650 (1000 w/ contrast) All 1500 Main or Ancillary Main Main Main Main Main Main MESA HF Main MESA HF MESA HF MESA Lung/NonSmk MESA Lung NonSmk MESA HF MESA AF Reception/Consent Change Clothes Blood Pressure Pulse Oximetry Anthropometry Phlebotomy Urine Collection Snack Echocardiography Arterial Tonometry Spirometry Lung CT 25 5 20 30 15 15 6 Minute Walk Test Patch Application
Exam 6 Questionnaires (~Day 1) Time 10 10 5 15 25 15 20 35 95 Sample All All All All All All 2650 1500 540 Main or Ancillary Main Main Main Main MESA HF MESA HF MESA Lung/NonSmk MESA AF Cognitive Function Testing MESA AF Medications Medical History Personal History Physical Activity HF Symptoms/Risk Physical Activity COPD Scores Cognitive Function Additional Cognitive Function Patch Application 15 1500
Exam 6 Other Visits Time 30 35 95 Sample 2650 1500 540 Main or Ancillary MESA Lung/NonSmk MESA AF Cognitive Function Testing Lung CT Brain MRI Carotid PET 15 1500 MESA AF Patch Application
Exam 6 Status Consent Template Reviewed by Steering, Operations, E6 Consent Committees Current draft posted on MESA E6 Planning webpage Forms and Content Committee is finalizing: Study Questionnaires and completion forms FU18 form packet
Exam 6 Status, ctd High tech and lab results letters Main text for letters is drafted, ready for Ops/PRC review CC/Ops working with ancillary study PIs to understand reporting for specific tests/procedures Safety reads for ECHO, CT
Participant Relations Committee Letters to MESA Contacts FU17 asks permission from participants to send letter or brochure to MESA Contacts (also added as an Exam 6 ICF item) PRC drafted letter to inform MESA Contacts of their role in MESA Participant Website Updates Spanish/Chinese translations now available for main participant webpages Article summaries and press releases are added monthly
Participant Relations Committee Newsletter Mail in June 2016 Announces Exam 6 and planned ancillary study components Next newsletter planned for November 2016 One newsletter per year planned for remainder of MESA 3 contract
