Overview of Antineoplastic Drugs and Hormonal Modulators
Explore the wide range of antineoplastic drugs including alkylating agents, antimetabolites, vinca alkaloids, taxanes, epipodophyllotoxins, antibiotics, and other miscellaneous drugs. Learn about hormonal modulators such as glucocorticoids, estrogens, selective estrogen receptor modulators, antiandrogens, aromatase inhibitors, and more. Also, discover immunosuppressants and their classifications. Get insights into the pharmacology of these medications and their mechanisms of action.
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Presentation Transcript
Anti Cancer - Antineoplastic Drugs - Overview A. Drugs acting directly on cells (Cytotoxic drugs) 1. Alkylating agents Mechlorethamine (Mustine HCl) Nitrogen mustards Cyclophosphamide, Ifosfamide, Chlorambucil, Melphalan. Ethylenimine Thio-TEPA Alkyl sulfonate Busulfan Nitrosoureas Carmustine (BCNU), Lomustine (CCNU), Triazine Dacarbazine (DTIC) Pharmawiki.in 1
2. Antimetabolites Folate antagonist Methotrexate (Mtx) Purine 6-Mercaptopurine (6-MP), antagonist 6-Thioguanine (6-TG), Azathioprine, Fludarabine Pyrimidine 5-Fluorouracil (5-FU), Cytarabine antagonist (cytosine arabinoside) 3. Vinca alkaloids Vincristine (Oncovin), Vinblastine 4. Taxanes Paclitaxel, Docetaxel Pharmawiki.in 2
5. Epipodophyllo Etoposide Toxin 6. Camptothecin Topotecan, Irinotecan Analogues 7. Antibiotics Actinomycin D (Dactinomycin) Doxorubicin, Daunorubicin (Rubidomycin), Mitoxantrone Bleomycins, Mitomycin C 8. Miscellaneous Hydroxyurea, Procarbazine, L-Asparaginase, Cisplatin, Carboplatin, Imatinib Pharmawiki.in 3
B. Drugs altering hormonal milieu 1. Glucocorticoids Prednisolone and others 2. Estrogens Fosfestrol, Ethinylestradiol 3. Selective estrogen Tamoxifen, Toremifene receptor modulators 4. Selective estrogen Fulvestrant receptor down regulator 5. Aromatase inhibitors Letrozole, Anastrozole, Exemestane 6. Antiandrogen Flutamide, Bicalutamide 7. 5-a reductase Finasteride, Dutasteride inhibitors 8. GnRH analogues Naferelin, Triptorelin 9. Progestins Hydroxyprogesterone caproate, etc. Pharmawiki.in 4
Miscellaneous Drugs Immunosuppressants 1. Calcineurin inhibitors (Specific T-cell inhibitors) Cyclosporine (Ciclosporin), Tacrolimus 2. Antiproliferative drugs (Cytotoxic drugs) Azathioprine, Cyclophosphamide, Methotrexate, Chlorambucil, Mycophenolate mofetil (MMF), Sirolimus 3. Glucocorticoids Prednisolone and others 4. Antibodies Muromonab CD3, Antithymocyte globulin (ATG), Rho(D) immuneglobulin Pharmawiki.in 5
