Pediatric Renal Transplant Study in Nordic Countries 1994-2016

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Explore the Pediatric Renal Transplant Study conducted by The Nordic Pediatric Renal Transplant Study Group from 1994 to 2016 in Aarhus, Copenhagen, and other cities. The study includes data on pediatric renal transplantations, age distribution, first transplants, recipient ages, and more in the Nordic countries. View insightful statistics and findings on renal transplants in children aged under 16 years.

  • Pediatric Renal Transplant
  • Nordic Countries
  • Pediatric Study
  • Transplant Data
  • Renal Transplantation
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  1. The Nordic Pediatric Renal Transplant Study Group 1994-2016

  2. The Nordic Pediatric Renal Transplant Study Group Aarhus Copenhagen I M Schmidt Odense Helsinki Oslo B Jespersen S Rittig Gothenburg Malm Stockholm Uppsala Reykjavik S Westphal L Mj rnstedt Z B kassy R K ll n M Herthelius L Wennberg G Celsi T Scholz V Edvardsson S S S rensen H Thiesson F Baudier T Jahnukainen H Jalanko A Bjerre R Horneland Coordinator M Tran ng 1994-2016

  3. Pediatric* renal transplantation in the Nordic countries Total:890 50 45 40 No of transplantations 35 30 25 20 15 10 5 0 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 LD (n=524) DD (n=366) * Recipient age < 16 years 1994-2016

  4. Pediatric* renal transplantation in the Nordic countries Total:890 50 45 40 No of transplantations 35 30 25 20 15 10 5 0 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 1st tx Re-tx before age 16 * Recipient age < 16 years 1994-2016

  5. Pediatric renal transplantation in the Nordic countries Age distribution/year Total: 890 50 45 40 No of transplantations 35 30 25 20 15 10 5 0 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 < 2 years 2-5 years 5-12 years 12-16 years 1994-2016

  6. Pediatric renal transplantation in the Nordic countries Age distribution/year 1st transplants only Total: 834 50 45 40 No of transplantations 35 30 25 20 15 10 5 0 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 < 2 years 2-5 years 5-12 years 12-16 years 1994-2016

  7. Pediatric renal transplantation in the Nordic countries No % Weight Mean SD Median (range) 27.9 16.9 24.0 (7.4-103.5) 10.6 1.5 10.6 (7.4-15.7) 13.9 2.4 13.8 (9.4-22.3) 26.3 9.9 24.4 (13.5-67.5) 45.5 14.0 44.0 (22.0-103.5) Age Mean SD Median (range) 8.6 5.1 9.3 (0.7-15.9) 1.4 0.3 1.4 (0.7-1.9) 3.3 0.9 3.1 (2.0-4.9) 8.9 1.9 8.9 (5.0-11.9) 14.2 1.2 14.2 (12.0-15.9) Sex 890 100% 532 M, 358 F 60% M, 40% F All 155 17.4% 94 M, 61 F 61% M, 39% F < 2 yrs 134 15.0% 87 M, 47 F 65% M, 35% F 2-5 yrs 296 33.3% 178 M, 118 F 60% M, 40% F 5-12 yrs 305 34.3% 173 M, 132 F 57% M, 43% F 12-16 yrs 1994-2016

  8. Age distribution of renal tx in Nordic children Age at tx < 2 yrs 2-5 yrs 5-12 yrs 12-16 yrs Finland 36% 19% 22% 23% Sweden 15% 13% 36% 36% Norway 14% 13% 32% 41% Denmark 4% 17% 42% 37% Iceland* - 20% 40% 40% *transplanted in Reykjavik 1994-2016

  9. Age distribution of renal tx in Nordic children 1st tx only Age at tx < 2 yrs 2-5 yrs 5-12 yrs 12-16 yrs Finland 37% 19% 21% 23% Sweden 16% 13% 35% 36% Norway 15% 12% 32% 40% Denmark 4% 17% 44% 35% Iceland* - 20% 40% 40% *transplanted in Reykjavik 1994-2016

  10. Age distribution of renal tx in Nordic children Age at tx < 2 yrs 2-5 yrs 5-12 yrs 12-16 yrs Tx era 94 - 03 04 - 16 94 - 03 04 - 16 94 - 03 04 - 16 94 - 03 04 - 16 Finland 28% 42% 19% 18% 31% 15% 22% 25% Sweden 15% 15% 8% 15% 41% 33% 36% 37% Norway 15% 14% 7% 16% 25% 36% 53% 34% Denmark 0% 6% 21% 14% 47% 40% 32% 40% Iceland - - - 20% - 40% - 40% 1994-2016

  11. Age distribution of renal tx in Nordic children No % Age Mean SD Median (range) 8.7 5.1 9.4 (0.8 15.9) 366 41% DD 524 59% 8.4 5.1 9.0 (0.7 15.9) LD 890 100% 8.5 5.1 9.3 (0.7 15.9) All 1994-2016

  12. Pediatric renal transplantation in the Nordic countries 250 LD (n=524) DD (n=366) No of transplantations 200 184 174 150 131 112 100 100 68 66 55 50 0 < 2 years 2-5 years 5-12 years 12-16 years Years of age 1994-2016

  13. Pediatric* renal transplantation in the Nordic countries % LD 83 % 73 % 50 % 26 % 250 232 200 No of transplantations 158 150 138 93 93 100 86 56 50 29 0 Norway Sweden Denmark Finland LD DD Iceland: 5 LD * Recipient age < 16 years 1994-2016

  14. Pediatric* renal transplantation in the Nordic countries Norway Sweden Denmark Finland Tx era 94-03 04-16 94-03 04-16 94-03 04-16 94-03 04-16 % LD 87 % 80 % 67 % 77 % 57 % 46 % 20 % 31 % 175 LD 94-03 LD 04-16 DD 94-03 DD 04-16 146 150 No of transplantations 125 100 86 80 79 79 75 63 58 53 43 43 50 40 36 30 20 20 25 9 0 Norway Sweden Denmark Finland * Recipient age < 16 years 1994-2016

  15. Pediatric* renal transplantation in the Nordic countries Norway Sweden Denmark Finland Tx era 94-03 04-09 10-16 94-03 04-09 10-16 94-03 04-09 10-16 94-03 04-09 10-16 % LD 87 % 80 % 80 % 67 % 87 % 71 % 57 % 45 % 47 % 20 % 18 % 43 % * Recipient age < 16 years 1994-2016

  16. Pediatric* renal transplantation in the Nordic countries Norway Sweden Denmark Finland Tx era 94-03 04-09 10-16 94-03 04-09 10-16 94-03 04-09 10-16 94-03 04-09 10-16 % LD 87 % 80 % 67 % 87 % 57 % 45 % 20 % 18 % 80 % 71 % 47 % 43 % Norway Sweden Denmark Finland Tx era 94-03 04-09 10-14 94-03 04-09 10-14 94-03 04-09 10-14 94-03 04-09 10-14 % LD 87 % 80 % 67 % 87 % 57 % 45 % 20 % 18 % 85 % 73 % 48 % 48 % * Recipient age < 16 years 1994-2016

  17. Pediatric* renal transplantation in the Nordic countries Patients in dialysis at first tx, LD Finland Denmark Norway Sweden % in dialysis % in dialysis % in dialysis % in dialysis n > 3 m pre tx > 6 m pre tx n > 3 m pre tx > 6 m pre tx n > 3 m pre tx > 6 m pre tx n > 3 m pre tx > 6 m pre tx 2004- 2016 36 75% 53% 50 69% 58% 76 83% 54% 141 80% 68% 2012- 2016 20 76% 59% 16 91% 82% 30 71% 71% 55 75% 59% * Recipient age < 16 years 1994-2016

  18. Pediatric* renal transplantation in the Nordic countries Combined transplantation Tx period: 1994-2016 Total no of tx: 890 Combined liver+kidney tx: 19 (18 recipients) * Recipient age < 16 years 1994-2016

  19. Graft survival* 2004-2016 Renal transplantation in children < 16 years 1,0 0,9 p< 0.05 0,8 Cumulative Proportion Surviving 0,7 0,6 0,5 0,4 0,3 0,2 LD (n=319) DD (n=205) 0,1 0,0 0 2 4 6 8 10 Years after transplantation * Censored for death with a functioning graft 1994-2016

  20. Patient survival 2004-2016 Renal transplantation in children < 16 years 1,0 ns 0,9 Cumulative Proportion Surviving 0,8 0,7 0,6 0,5 0,4 0,3 0,2 LD* (n=308) DD* (n=184) 0,1 0,0 0 4 6 8 10 2 Years after transplantation * Donor type at first transplant 1994-2016

  21. Graft survival* 2004-2016 Living donor transplantation 2004-2016 1,0 0,9 Cumulative Proportion Surviving 0,8 0,7 0,6 0,5 0,4 0,3 0,2 Rec age <2 years (n=66) Rec age 2-5 years (n=41) Rec age 5-12 years (n=103) Rec age 12-16 years (n=109) 0,1 0,0 0 4 6 8 10 2 Years after transplantation * Censored for death with a functioning graft 1994-2016

  22. Graft survival* 2004-2016 Deceased donor transplantation 2004-2016 1,0 0,9 Cumulative Proportion Surviving 0,8 0,7 0,6 0,5 0,4 0,3 0,2 Rec age <2 years (n=32) Rec age 2-5 years (n=42) Rec age 5-12 years (n=59) Rec age 12-16 years (n=72) 0,1 0,0 0 4 6 8 10 2 Years after transplantation * Censored for death with a functioning graft 1994-2016

  23. Patient survival 2004-2016 Living donor transplantation 2004-2016 1,00 0,95 Cumulative Proportion Surviving 0,90 0,85 0,80 Rec age < 2 years (n=66) Rec age 2-5 years (n=41) Rec age 5-12 years (n=98) Rec age 12-16 years (n=103) 0,75 0,70 0 4 6 8 10 2 Years after transplantation 1994-2016

  24. Patient survival 2004-2016 Deceased donor transplantation 2004-2016 1,00 0,95 Cumulative Proportion Surviving 0,90 0,85 0,80 Rec age < 2 years (n=31) Rec age 2-5 years (n=38) Rec age 5-12 years (n=51) Rec age 12-16 years (n=64) 0,75 0,70 0 4 6 8 10 2 Years after transplantation 1994-2016

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