Polycythemia: Symptoms, Causes, and Treatment
Polycythemia is characterized by an abnormal increase in blood cells, leading to various symptoms such as itching, headaches, and dizziness. It is not hereditary but linked to gene defects like JAK2 V617F. This article explores the causes, symptoms, complications, and treatments of polycythemia along with normal vs. abnormal blood cell ranges. References and resources are provided for further information.
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Presentation Transcript
Polycythemia GRACE ORDUNG
What is Polycythemia? Abnormal increase in blood cells Red, white and platelets Classified as a cancer Acquired not heredity Defect in gene JAK2 V617F
Symptoms, Complications and Risk Factors Itching, headache, dizziness, weakness, sweating, breathing problems, enlarged spleen, numbness, etc. Stroke, heart problems Increases with age, men more than women
Normal vs. Polycythemia Normal Hb Male: 13.5-17.5 g/dL Female: 12.0-15.5 g/dL Hematocrit Male: 38.8-50.0% Female 34.9-44.5 % WBC: 3,500-10,500 cells/uL Platelets: 150-450,000 platelets/uL PV Hb Male: > 18.5 g/dL Female: > 16.5 g/dL WBC: > 12,000 cells/uL Platelets: > 400,000 platelets/ uL
JAK2 V617F Gene Cause of defect unknown China Japan Union Hospital, Changchun, China 3935 donors Copenhagen City Heart Study 10,507 donors
Treatments Phlebotomies Asprinin, hydroxyurea, Interferon A Antihistamines Lifestyle changes
References http://www.nlm.nih.gov/medlineplus/ency/article/000589.htm http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046277/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785080/ http://www.cancer.gov/cancertopics/types/myeloproliferative http://www.mayoclinic.org/diseases-conditions/polycythemia-vera/basics/complications/con- 20031013 http://www.cancer.org/treatment/treatmentsandsideeffects/guidetocancerdrugs/hydroxyurea http://ajcp.ascpjournals.org/content/133/6/942/F1.expansion.html http://www.cancer.gov/cancertopics/pdq/treatment/myeloproliferative/HealthProfessional/page3 http://www.mayoclinic.org/tests-procedures/complete-blood-count/basics/results/prc-20014088 http://www.nlm.nih.gov/medlineplus/ency/article/003683.htm
