Potent Cancer Treating Compounds Overview
An overview of potent cancer treating compounds including cisplatin, carboplatin, arsenic trioxide, hydroxyurea, guanazole diaminotriazole, mitoxatrone hydrochloride, hexamethylmelamine, and gallium nitrate, each with unique modes of action and specific uses. These compounds are utilized in the treatment of various types of cancer such as testicular, ovarian, lung, head and neck, and leukemia through mechanisms like DNA synthesis inhibition and apoptosis induction.
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Presentation Transcript
Miscellaneous compounds Cisplatin Mode of action a potent inhibitor of DNApolymerase intrastrand cross linkage by the platinum complex
Uses: - 1. Cisplatin is used in combination with bleomycin and vinblastine for metastatic testiculartumors. 2. Used alone or in combination with doxorubicin for metastatic ovarian tumors, also penile cancer, bladder cancer, cervical cancer, head and neck cancer, and small cell cancer of the lung.
Carboplatin Uses: -treatment of ovarian cancer, non small cell lung cancer, head and neck cancer, and testicular cancer. Mode of action resemble to cisplatine.
Arsenic trioxide(As2O3), trisenox:- Uses and mechanism of action : - stimulation of apoptosis activity and stimulation of caspase enzymes
Hydroxyurea Mode ofaction Uses: - Its active against melanoma, chronic myelocytic leukemia and metastatic ovarian carcinoma. Used in combination with radiotherapyfor head and neck cancer.
Guanazole diaminotriazole Mode of action This diaminotriazole resembles hydroxyurea in its ability to limit DNA synthesis by inhibiting the reduction of rihonucleotides. Uses: - It is clinically active in inducing remissions of acute adult leukemia.
Gallium Nitrate (Ganite) Ga(NO3)3.9H2O Gallium nitrate is approved for treatingcancer- related hypercalcemia. Gallium nitrate probably works in hypercalcemia by inhibiting calcium resorption from bone.
